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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×

A self-inactivating system for AAV-mediated in vivo base editing

Abstract: DNA base editors have been harnessed as an exciting therapeutic platform for human diseases and are rapidly progressing into human clinical trials. However, persistent expression of base editors delivered via adeno-associated virus (AAV) poses con...
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Antibody CRISPR

BET protein inhibition sensitizes glioblastoma cells to temozolomidetreatment by attenuating MGMT expression

Abstract: Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small mole...
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Bioruptor Antibody iDeal ChIP-seq Kit for Transcription Factors

PRAME induces genomic instability in uveal melanoma

Abstract: PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in sperm...
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Antibody

Nucleophosmin 1 cooperates with the methyltransferase DOT1L toregulate H3K79me2 levels and DNA satellites expression atperi-nucleolar heterochromatin

Abstract: The histone methyltransferase DOT1L catalyzes methylation of H3K79 and it is highly conserved in mammals. DOT1L plays a functional role in several biological processes including cell cycle regulation, DNA repair, RNA splicing and gene expression, ...
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Bioruptor Antibody

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