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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
Targeting high glucose-induced epigenetic modifications at cardiac level:the role of SGLT2 and SGLT2 inhibitors.
Published: February, 2023
Abstract: BACKGROUND: Sodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of action have been identified. However, no data on their capability to act via epigenetic mechani...
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Antibody
Myelodysplastic Syndrome associated TET2 mutations affect NK cellfunction and genome methylation.
Published: February, 2023
Abstract: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to somatic mutations, notably in the epigenetic regulator TET2. Natural Killer (NK) cel...
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Antibody Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Species-specific regulation of XIST by the JPX/FTX orthologs.
Published: February, 2023
Abstract: X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolv...
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Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 inAlzheimer's disease.
Published: February, 2023
Abstract: Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer's disease (AD) may be the mechanism relating age-related metabolic disorders to dementia. Since Igf2 is an imprinted gene, we examined age and sex differences in the relationship betw...
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Detailed molecular and epigenetic characterization of the Pig IPECJ2and Chicken SL-29 cell lines
Published: February, 2023
Abstract: The pig IPECJ2 and chicken SL-29 cell lines are of interest because of their untransformed nature and wide use in functional studies. Molecular characterization of these cell lines is important to gain insight into possible molecular aberrations. ...
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Cotranscriptional demethylation induces global loss of H3K4me2 fromactive genes in Arabidopsis
Published: February, 2023
Abstract: Based on studies of animals and yeasts, methylation of histone H3 lysine 4 (H3K4me1/2/3, for mono-, di-, and tri-methylation, respectively) is regarded as the key epigenetic modification of transcriptionally active genes. In plants, however, H3K4m...
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Histone remodeling reflects conserved mechanisms of bovine and humanpreimplantation development.
Published: February, 2023
Abstract: How histone modifications regulate changes in gene expression during preimplantation development in any species remains poorly understood. Using CUT\&Tag to overcome limiting amounts of biological material, we profiled two activating (H3K4me3 ...
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Epigenetic regulation of plastin 3 expression by the macrosatelliteDXZ4 and the transcriptional regulator CHD4.
Published: February, 2023
Abstract: Dysregulated Plastin 3 (PLS3) levels associate with a wide range of skeletal and neuromuscular disorders and the most common types of solid and hematopoietic cancer. Most importantly, PLS3 overexpression protects against spinal muscular atrophy. D...
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Antibody iDeal ChIP-qPCR
Signal-induced enhancer activation requires Ku70 to readtopoisomerase1-DNA covalent complexes.
Published: February, 2023
Abstract: Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topoisomerase...
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Methylation and expression of glucocorticoid receptor exon-1 variants andFKBP5 in teenage suicide-completers.
Published: February, 2023
Abstract: A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the ...
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MagMeDIP kit Antibody hMeDIP
Bridging biological cfDNA features and machine learning approaches.
Published: February, 2023
Abstract: Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to revolutionize precision oncology and blood-based cancer screening. Recent technological improvements, in combination with the ever-growing understanding of ce...
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MagMeDIP kit Antibody
Temporal modification of H3K9/14ac and H3K4me3 histone marksmediates mechano-responsive gene expression during the accommodationprocess in poplar
Published: February, 2023
Abstract: Plants can attenuate their molecular response to repetitive mechanical stimulation as a function of their mechanical history. For instance, a single bending of stem is sufficient to attenuate the gene expression in poplar plants to the subsequent ...
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Antibody Universal Plant ChIP-seq Kit
Incomplete transcriptional dosage compensation of vertebrate sexchromosomes is balanced by post-transcriptional compensation
Published: February, 2023
Abstract: Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. How...
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Gene body DNA hydroxymethylation restricts the magnitude oftranscriptional changes during aging.
Published: February, 2023
Abstract: DNA hydroxymethylation (5hmC) is the most abundant oxidative derivative of DNA methylation (5mC) and is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been ...
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MagMeDIP kit Antibody hMeDIP
Epigenomic charting and functional annotation of risk loci in renal cellcarcinoma.
Published: January, 2023
Abstract: While the mutational and transcriptional landscapes of renal cell carcinoma (RCC) are well-known, the epigenome is poorly understood. We characterize the epigenome of clear cell (ccRCC), papillary (pRCC), and chromophobe RCC (chRCC) by using ChIP-...
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Auxin-inducible degron 2 system deciphers functions of CTCF domains intranscriptional regulation.
Published: January, 2023
Abstract: BACKGROUND: CTCF is a well-established chromatin architectural protein that also plays various roles in transcriptional regulation. While CTCF biology has been extensively studied, how the domains of CTCF function to regulate transcription remains...
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Methyltransferase Inhibition Enables Tgf Driven Induction of and in Cancer Cells.
Published: January, 2023
Abstract: deletion or silencing is common across human cancer, reinforcing the general importance of bypassing its tumor suppression in cancer formation or progression. In rhabdomyosarcoma (RMS) and neuroblastoma, two common childhood cancers, the three tra...
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Antibody CRISPR
Analyzing the Genome-Wide Distribution of Histone Marks byCUT\&Tag in Drosophila Embryos.
Published: January, 2023
Abstract: CUT&Tag is a method to map the genome-wide distribution of histone modifications and some chromatin-associated proteins. CUT&Tag relies on antibody-targeted chromatin tagmentation and can easily be scaled up or automatized. This protocol p...
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The age of bone marrow dictates the clonality of smooth muscle-derivedcells in atherosclerotic plaques.
Published: January, 2023
Abstract: Aging is the predominant risk factor for atherosclerosis, the leading cause of death. Rare smooth muscle cell (SMC) progenitors clonally expand giving rise to up to ~70\% of atherosclerotic plaque cells; however, the effect of age on SMC clonality...
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Antibody hMeDIP
DNA dioxygenases Tet2/3 regulate gene promoter accessibility andchromatin topology in lineage-specific loci to control epithelialdifferentiation.
Published: January, 2023
Abstract: Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes, catalyzing 5-methylcytosine oxidation in DNA. Here, by using --driven ablation of g...
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Antibody
Quantifying propagation of DNA methylation and hydroxymethylation withiDEMS.
Published: January, 2023
Abstract: DNA methylation is a critical epigenetic mark in mammalian cells. Many aspects of DNA methylation maintenance have been characterized; however, the exact kinetics of post-replicative methylation maintenance remain a subject of debate. Here we deve...
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Role of epigenetics in the etiology of hypospadias through penileforeskin DNA methylation alterations.
Published: January, 2023
Abstract: Abnormal penile foreskin development in hypospadias is the most frequent genital malformation in male children, which has increased dramatically in recent decades. A number of environmental factors have been shown to be associated with hypospadias...
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Gene Regulatory Interactions at Lamina-Associated Domains
Published: January, 2023
Abstract: The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How the...
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Antibody Microplex Library Preparation kit
Simultaneous profiling of histone modifications and DNA methylation viananopore sequencing.
Published: December, 2022
Abstract: The interplay between histone modifications and DNA methylation drives the establishment and maintenance of the cellular epigenomic landscape, but it remains challenging to investigate the complex relationship between these epigenetic marks across...
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CUT&Tag
Consistent DNA Hypomethylations in Prostate Cancer.
Published: December, 2022
Abstract: With approximately 1.4 million men annually diagnosed with prostate cancer (PCa) worldwide, PCa remains a dreaded threat to life and source of devastating morbidity. In recent decades, a significant decrease in age-specific PCa mortality has been ...
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MagMeDIP kit Antibody
The histone acetyltransferase KAT6A is recruited to unmethylatedCpG islands via a DNA binding winged helix domain.
Published: December, 2022
Abstract: The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AM...
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Antibody Microplex Library Preparation kit
KMT2D deficiency drives lung squamous cell carcinoma andhypersensitivity to RTK-RAS inhibition.
Published: December, 2022
Abstract: Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (>20\%), and yet its role in LUSC oncogenesis remains unknown. Here, we iden...
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Antibody
K27M in canonical and noncanonical H3 variants occurs in distinctoligodendroglial cell lineages in brain midline gliomas.
Published: December, 2022
Abstract: Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and molecular profiles. The contribution of the cell of origin to these differences has been challenging to u...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Heterocycle-containing tranylcypromine derivatives endowed with highanti-LSD1 activity.
Published: December, 2022
Abstract: As regioisomers/bioisosteres of , a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives -, in which the 4-phenyl moi...
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Trichoderma root colonization triggers epigenetic changes in jasmonic andsalicylic acid pathway-related genes.
Published: December, 2022
Abstract: Beneficial interactions between plant-roots and Trichoderma spp. lead to a local and systemic enhancement of the plant immune system through a mechanism known as priming of defenses. In recent reports, we outlined a repertoire of genes and protein...
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Antibody

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