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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×
FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues.
Published: June, 2020
Abstract: Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in formalin-fixed, paraffin-embedded (FFPE) tissues. We previously developed a modified ChIP-seq proto...
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Antibody
The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications.
Published: June, 2020
Abstract: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with pote...
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Antibody
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.
Published: June, 2020
Abstract: Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show...
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MagMeDIP kit Antibody
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Published: June, 2020
Abstract: Improving early cancer detection has the potential to substantially reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) is a highly sensitive assay capable of detecting early-s...
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MagMeDIP kit Antibody IPure kit
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
Published: June, 2020
Abstract: How the epigenetic landscape is established in development is still being elucidated. Here, we uncover developmental pluripotency associated 2 and 4 (DPPA2/4) as epigenetic priming factors that establish a permissive epigenetic landscape at a subs...
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Antibody Microplex Library Preparation kit
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.
Published: June, 2020
Abstract: A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on-target mutations or parallel pathway alterati...
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Antibody Microplex Library Preparation kit
Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia.
Published: June, 2020
Abstract: Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease, with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensiv...
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Antibody
DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain.
Published: June, 2020
Abstract: Methylation of cytosine residues in DNA influences chromatin structure and gene transcription, and its regulation is crucial for brain development. There is mounting evidence that DNA methylation can be modulated by hormone signaling. We analyzed ...
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Antibody MethylCap
An optimised Chromatin Immunoprecipitation (ChIP) method for starchy leaves of Nicotiana benthamiana to study histone modifications of an allotetraploid plant
Published: June, 2020
Abstract: All flowering plants have evolved through multiple rounds of polyploidy throughout the evolutionary process. Intergenomic interactions between subgenomes in polyploid plants are predicted to induce chromatin modifications such as histone modificat...
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Antibody
Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer
Published: June, 2020
Abstract: RING1B, a core Polycomb repressive complex 1 subunit, is a histone H2A ubiquitin ligase essential for development. RING1B is overexpressed in patients with luminal breast cancer (BC) and recruited to actively transcribed genes and enhancers co-occ...
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Antibody
Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy.
Published: June, 2020
Abstract: BACKGROUND: Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and promoters. The binding of transcriptional regulators enables the interaction betwee...
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Antibody
A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.
Published: June, 2020
Abstract: Heterochromatic domains containing histone H3 lysine 9 methylation (H3K9me) can be epigenetically inherited independently of underlying DNA sequence. To gain insight into the mechanisms that mediate epigenetic inheritance, we used a inducible hete...
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Antibody
Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation.
Published: June, 2020
Abstract: Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition into the transcriptionally active state. However, the mechanisms underlying euchromatin establishment during early embryogenesis remain poorly under...
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Antibody
AXR1 affects DNA methylation independently of its role in regulatingmeiotic crossover localization.
Published: June, 2020
Abstract: Meiotic crossovers (COs) are important for reshuffling genetic information between homologous chromosomes and they are essential for their correct segregation. COs are unevenly distributed along chromosomes and the underlying mechanisms controllin...
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Antibody
The hypomethylation of imprinted genes in IVF/ICSI placenta samplesis associated with concomitant changes in histone modifications.
Published: June, 2020
Abstract: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with pote...
Read more »
Tags
Antibody
The 20S proteasome activator PA28γ controls the compaction of chromatin
Published: May, 2020
Abstract: The nuclear PA28γ is known to activate the 20S proteasome, but its precise cellular functions remains unclear. Here, we identify PA28γ as a key factor that structures heterochromatin. We find that in human cells, a fraction of PA28&gam...
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Antibody
Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.
Published: May, 2020
Abstract: The Ikzf1 locus encodes the lymphoid specific transcription factor Ikaros, which plays an essential role in both T and B cell differentiation, while deregulation or mutation of IKZF1/Ikzf1 is involved in leukemia. Tissue-specific and cell identity...
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Antibody
Measuring Histone Modifications in the Human Parasite Schistosoma mansoni
Published: May, 2020
Abstract: DNA-binding proteins play critical roles in many major processes such as development and sexual biology of Schistosoma mansoni and are important for the pathogenesis of schistosomiasis. Chromatin immunoprecipitation (ChIP) experiments followed by ...
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IP-Star Antibody
Histone post-translational modifications in Silene latifolia X and Y chromosomes suggest a mammal-like dosage compensation system
Published: May, 2020
Abstract: Silene latifolia is a model organism to study evolutionary young heteromorphic sex chromosome evolution in plants. Previous research indicates a Y-allele gene degeneration and a dosage compensation system already operating. Here, we propose an epi...
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Antibody
AP-1 controls the p11-dependent antidepressant response.
Published: May, 2020
Abstract: Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed drugs for mood disorders. While the mechanism of SSRI action is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular serotonin level...
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Antibody Beads ChIP Cross-link Gold
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Published: May, 2020
Abstract: Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased charact...
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Antibody IP-Star Compact
Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.
Published: May, 2020
Abstract: Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not full...
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Antibody
β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.
Published: May, 2020
Abstract: β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained immunity," resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exp...
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Antibody
DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression.
Published: May, 2020
Abstract: To accomplish the remarkable task of lifelong infection, the Epstein-Barr virus (EBV) switches between four viral genome latency and lytic programmes to navigate the B-cell compartment and evade immune responses. The transforming programme, consis...
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MagMeDIP kit Antibody
DNA methylation variation in the brain of laying hens in relation to differential behavioral patterns
Published: May, 2020
Abstract: Domesticated animals are unique to investigate the contribution of genetic and non-genetic factors to specific phenotypes. Among non-genetic factors involved in phenotype formation are epigenetic mechanisms. Here we aimed to identify whether relat...
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Antibody
MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma.
Published: May, 2020
Abstract: Despite the improvement in clinical outcome with 13-cis-retinoic acid (13-cisRA) + anti-GD2 antibody + cytokine immunotherapy given in first response ~40% of high-risk neuroblastoma patients die of recurrent disease. MYCN genomic amplification is ...
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iDeal ChIP-seq Kit for Transcription Factors
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.
Published: May, 2020
Abstract: The acquisition of cell identity is associated with developmentally regulated changes in the cellular histone methylation signatures. For instance, commitment to neural differentiation relies on the tightly controlled gain or loss of H3K27me3, a h...
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Antibody
Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock.
Published: May, 2020
Abstract: Accumulating evidence points to a significant link between disrupted circadian rhythms and neuronal disfunctions, though the molecular mechanisms underlying this connection are virtually unexplored. The transcript Homer1a, an immediate early gene ...
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Antibody
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1.
Published: May, 2020
Abstract: Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles ar...
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Antibody
In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states.
Published: May, 2020
Abstract: Following implantation, the naive pluripotent epiblast of the mouse blastocyst generates a rosette, undergoes lumenogenesis and forms the primed pluripotent egg cylinder, which is able to generate the embryonic tissues. How pluripotency progressio...
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Antibody

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