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Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.


Nassiri F, Chakravarthy A, Feng S, Shen SY, Nejad R, Zuccato JA, Voisin MR, Patil V, Horbinski C, Aldape K, Zadeh G, De Carvalho DD

Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that share cell-of-origin lineages and can be challenging to distinguish using standard-of-care imaging.

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Published
June, 2020

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  • Mouse IgG
    C15200081-100
    5-methylcytosine (5-mC) Antibody - clone 33D3
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    C02010021
    MagMeDIP qPCR Kit
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    C02010040
    MagMeDIP-seq Package
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    MagMeDIP-seq Pacakge V2

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