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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Environmental enrichment preserves a young DNA methylation landscape inthe aged mouse hippocampus
Published: June, 2021
Abstract: The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using g...
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Antibody Premium RRBS Kit iDeal ChIP-seq Kit for Transcription Factors
Highly recurrent epimutations in gastric cancer CpG islandmethylator phenotypes and inflammation
Published: June, 2021
Abstract: Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (GC), m...
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Antibody
Epigenetic Plasticity Enables CNS-Trafficking of EBV-infectedB Lymphocytes
Published: June, 2021
Abstract: Subpopulations of B-lymphocytes traffic to different sites and organs to provide diverse and tissue-specific functions. Here, we provide evidence that epigenetic differences confer a neuroinvasive phenotype. An EBV+ B cell lymphoma cell line (M14)...
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MagMeDIP kit
LINE-1 transcription in round spermatids is associated with accretion of5-carboxylcytosine in their open reading frames
Published: June, 2021
Abstract: Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been exten...
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Lasp1 regulates adherens junction dynamics and fibroblast transformationin destructive arthritis
Published: June, 2021
Abstract: The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the...
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Antibody IP-Star Compact Microplex Library Preparation kit
HOTAIR lncRNA promotes epithelial-mesenchymal transition byredistributing LSD1 at regulatory chromatin regions.
Published: May, 2021
Abstract: Epithelial-to-mesenchymal transition (EMT) describes the loss of epithelial traits and gain of mesenchymal traits by normal cells during development and by neoplastic cells during cancer metastasis. The long noncoding RNA HOTAIR triggers EMT, in p...
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The lncRNA and the transcription factor WRKY42 target common cell wallEXTENSIN encoding genes to trigger root hair cell elongation.
Published: May, 2021
Abstract: Plant long noncoding RNAs (lncRNAs) are key chromatin dynamics regulators, directing the transcriptional programs driving a wide variety of developmental outputs. Recently, we uncovered how the lncRNA () directly recognizes the locus encoding the ...
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Placental uptake and metabolism of 25(OH)Vitamin D determines itsactivity within the fetoplacental unit
Published: May, 2021
Abstract: Pregnancy 25-hydroxyvitamin D (25(OH)D) concentrations are associated with maternal and fetal health outcomes, but the underlying mechanisms have not been elucidated. Using physiological human placental perfusion approaches and intact villous expl...
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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.
Published: May, 2021
Abstract: Depleting the microenvironment of important nutrients such as arginine is a key strategy for immune evasion by cancer cells. Many tumors overexpress arginase, but it is unclear how these cancers, but not T cells, tolerate arginine depletion. ...
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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Published: May, 2021
Abstract: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using flu...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Published: May, 2021
Abstract: Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer. Nonetheless, regulat...
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Identification of a PadR-type regulator essential for intracellularpathogenesis of
Published: May, 2021
Abstract: Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a disease endemic to the tropics. Melioidosis manifests in various ways ranging from acute skin lesions to pneumonia and, in rare cases, infection of the central nervous system....
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Epigenomic profiling of primate lymphoblastoid cell lines reveals theevolutionary patterns of epigenetic activities in gene regulatoryarchitectures
Published: May, 2021
Abstract: Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone...
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GATA6 defines endoderm fate by controlling chromatin accessibility duringdifferentiation of human-induced pluripotent stem cells
Published: May, 2021
Abstract: SUMMARY In addition to driving specific gene expression profiles, transcriptional regulators are becoming increasingly recognized for their capacity to modulate chromatin structure. GATA6 is essential for the formation of definitive endoderm; howe...
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The SAM domain-containing protein 1 (SAMD1) acts as a repressivechromatin regulator at unmethylated CpG islands
Published: May, 2021
Abstract: CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-...
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Antibody Microplex Library Preparation kit
MeCP2 controls neural stem cell fate specification throughmiR-199a-mediated inhibition of BMP-Smad signaling.
Published: May, 2021
Abstract: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a specific ...
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Simplification of culture conditions and feeder-free expansion of bovineembryonic stem cells
Published: May, 2021
Abstract: Bovine embryonic stem cells (bESCs) extend the lifespan of the transient pluripotent bovine inner cell mass in vitro. After years of research, derivation of stable bESCs was only recently reported. Although successful, bESC culture relies on compl...
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Androgen and glucocorticoid receptor direct distinct transcriptionalprograms by receptor-specific and shared DNA binding sites.
Published: April, 2021
Abstract: The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. To identify mechanisms that facilitate functional diversification among these transcription factor paralogs,...
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USP22 Suppresses Expression in Acute Colitis and Inflammation-AssociatedColorectal Cancer.
Published: April, 2021
Abstract: As a member of the 11-gene "death-from-cancer" gene expression signature, ubiquitin-specific protease 22 (USP22) has been considered an oncogene in various human malignancies, including colorectal cancer (CRC). We recently identified an unexpected...
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Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls
Published: April, 2021
Abstract: Background. Cell-free methylated DNA immunoprecipitation-sequencing (cfMeDIP-seq) identifies genomic regions with DNA methylation, using a protocol adapted to work with low-input DNA samples and with cell-free DNA (cfDNA). This method allows for D...
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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Published: April, 2021
Abstract: Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei...
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The anti-inflammatory cytokine interleukin-37 is an inhibitor of trainedimmunity.
Published: April, 2021
Abstract: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post...
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Dynamic association of the H3K64 trimethylation mark with genes encodingexported proteins in Plasmodium falciparum.
Published: April, 2021
Abstract: Epigenetic modifications have emerged as critical regulators of virulence genes and stage-specific gene expression in Plasmodium falciparum. However, the specific roles of histone core epigenetic modifications in regulating the stage-specific gene...
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Chd8 regulates X chromosome inactivation in mouse through fine-tuningcontrol of Xist expression.
Published: April, 2021
Abstract: Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is ...
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Comparative analysis of histone H3K4me3 modifications between blastocystsand somatic tissues in cattle.
Published: April, 2021
Abstract: Epigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequences throughout life. This concept constitutes the "Developmental Origins of Health and Disease" (D...
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Genetic perturbation of PU.1 binding and chromatin looping at neutrophilenhancers associates with autoimmune disease.
Published: April, 2021
Abstract: Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master ...
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Epigenomic landscape of human colorectal cancer unveils an aberrant core ofpan-cancer enhancers orchestrated by YAP/TAZ.
Published: April, 2021
Abstract: Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) u...
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Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-inducedprogrammed cell death in Arabidopsis.
Published: April, 2021
Abstract: The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset of senes...
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Antibody Microplex Library Preparation kit
Fra-1 regulates its target genes via binding to remote enhancers withoutexerting major control on chromatin architecture in triple negative breastcancers.
Published: March, 2021
Abstract: The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is still ill-understood. The Fos family prot...
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Loss of SETD1B results in the redistribution of genomic H3K4me3 in theoocyte
Published: March, 2021
Abstract: Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian development, yet mechanisms underlying its genomic targeting are poorly understood. H3K4me3 methyltransfe...
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Antibody Microplex Library Preparation kit

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