SUV39 SET domains mediate crosstalk of heterochromatic histone marks. Published: September, 2021 Abstract:
The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How these enzymes are regulated to mark specific genomic regions as heterochromatic is poor... Read more » Tags BioruptorAntibody
Coordination of EZH2 and SOX2 specifies human neural fate decision. Published: September, 2021 Abstract:
Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different ... Read more » Tags Antibody
Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells. Published: September, 2021 Abstract:
Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1)... Read more » Tags Antibody
WT1 regulates HOXB9 gene expression in a bidirectional way. Published: September, 2021 Abstract:
The homeoboxB9 (HOXB9) gene is necessary for specification of the anterior-posterior body axis during embryonic development and expressed in various types of cancer. Here we show that the Wilms tumor transcription factor WT1 regulates the HOXB9 ge... Read more » Tags Antibody
Aiolos regulates eosinophil migration into tissues. Published: August, 2021 Abstract:
Expression of Ikaros family transcription factor IKZF3 (Aiolos) increases during murine eosinophil lineage commitment and maturation. Herein, we investigated Aiolos expression and function in mature human and murine eosinophils. Murine eosinophils... Read more » Tags Antibody
Phase separation drives aberrant chromatin looping and cancerdevelopment. Published: July, 2021 Abstract:
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP... Read more » Tags Antibody
