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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Distinct effects on the secretion of MTRAP and AMA1 in Plasmodiumyoelii following deletion of acylated pleckstrin homology domain-containingprotein.
Published: February, 2022
Abstract: Plasmodium, the causative agents of malaria, are obligate intracellular organisms. In humans, pathogenesis is caused by the blood stage parasite, which multiplies within erythrocytes, thus erythrocyte invasion is an essential developmental step. M...
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Antibody
Antisense non-coding transcription represses the PHO5 model genevia remodelling of promoter chromatin structure
Published: February, 2022
Abstract: Pervasive transcription of eukaryotic genomes generates non-coding transcripts with regulatory potential. We examined the effects of non-coding antisense transcription on the regulation of expression of the yeast PHO5 gene, a paradigmatic case for...
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Antibody CRISPR
Cell-type specific transcriptional networks in root xylem adjacent celllayers
Published: February, 2022
Abstract: Transport of water, ions and signals from roots to leaves via the xylem vessels is essential for plant life and needs to be tightly regulated. The final composition of the transpiration stream before passage into the shoots is controlled by the xy...
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Antibody
Screening of ETO2-GLIS2-induced Super Enhancers identifiestargetable cooperative dependencies in acute megakaryoblastic leukemia.
Published: February, 2022
Abstract: Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and disease. However, whether these elements are induced by oncogenes and can regulate gene modules cooperating for cancer cell transformation or maintenance r...
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Antibody iDeal ChIP-seq Kit for Histones
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
Published: January, 2022
Abstract: Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to understand themolecular processes that drive MM biology. Epigenetic modifications are involved in MM development,progression, and drug resistance. A comprehensive ...
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Antibody Bioruptor Plus IPure kit IP-Star Compact
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
Published: January, 2022
Abstract: Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to understand the molecular processes that drive MM biology. Epigenetic modifications are involved in MM development, progression, and drug resistance. A comprehensiv...
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Bioruptor Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Human centromere formation activates transcription and opens chromatinfibre structure
Published: January, 2022
Abstract: Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for ...
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Antibody
Pre-configuring chromatin architecture with histone modifications guideshematopoietic stem cell formation in mouse embryos.
Published: January, 2022
Abstract: The gene activity underlying cell differentiation is regulated by a diverse set of transcription factors (TFs), histone modifications, chromatin structures and more. Although definitive hematopoietic stem cells (HSCs) are known to emerge via endot...
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Antibody
NuA4 and H2A.Z control environmental responses and autotrophicgrowth in Arabidopsis
Published: January, 2022
Abstract: Nucleosomal acetyltransferase of H4 (NuA4) is an essential transcriptional coactivator in eukaryotes, but remains poorly characterized in plants. Here, we describe Arabidopsis homologs of the NuA4 scaffold proteins Enhancer of Polycomb-Like 1 (AtE...
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Antibody Microplex Library Preparation kit
DNMT1 regulates the timing of DNA methylation by DNMT3 in anenzymatic activity-dependent manner in mouse embryonic stem cells.
Published: January, 2022
Abstract: DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: DNA methyltransferases (DNMTs) and Ten-eleven translocation dioxygenas...
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Antibody
Coordinated glucocorticoid receptor and MAFB action inducestolerogenesis and epigenome remodeling in dendritic cells
Published: January, 2022
Abstract: Abstract Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune responses, acquire tolerogenic properties in response to ...
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Antibody IPure kit
Mod(mdg4) variants repress telomeric retrotransposon HeT-A byblocking subtelomeric enhancers
Published: January, 2022
Abstract: Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: HeT-A, TART , and TAHRE . Although they are repressed by the piRNA pathway in the germline, how these retrotransposons are regulated in somatic cells is poorly understood...
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Antibody
Loss of KMT2C reprograms the epigenomic landscape in hPSCsresulting in NODAL overexpression and a failure of hemogenic endotheliumspecification.
Published: January, 2022
Abstract: Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, -fusions are prevalent in 70\% of infant leukaemias but fail to phenocopy short latency...
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Antibody
Stella regulates the Development of Female Germline Stem Cells byModulating Chromatin Structure and DNA Methylation.
Published: January, 2022
Abstract: Female germline stem cells (FGSCs) have the ability to self-renew and differentiate into oocytes. , encoded by a maternal effect gene, plays an important role in oogenesis and early embryonic development. However, its function in FGSCs remains unc...
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MagMeDIP kit Antibody
Effects of GSK-J4 on JMJD3 Histone Demethylase in MouseProstate Cancer Xenografts.
Published: January, 2022
Abstract: BACKGROUND/AIM: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and has b...
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Bioruptor Antibody iDeal ChIP-seq Kit for Histones
Single amino-acid mutation in a Drosoph ila melanogaster ribosomalprotein: An insight in uL11 transcriptional activity.
Published: January, 2022
Abstract: The ribosomal protein uL11 is located at the basis of the ribosome P-stalk and plays a paramount role in translational efficiency. In addition, no mutant for uL11 is available suggesting that this gene is haplo-insufficient as many other Ribosomal...
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Antibody
Chemokine switch regulated by TGF-β1 in cancer-associated fibroblastsubsets determines the efficacy of chemo-immunotherapy.
Published: January, 2022
Abstract: Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can generate remarkable tumor responses. It is now well established that TGF-β1 signaling is a major component of treatment resistance and contributes to the cancer-re...
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Antibody IP-Star Compact
27-Hydroxycholesterol, The Estrogen Receptor Modulator, AltersDNA Methylation in Breast Cancer.
Published: January, 2022
Abstract: 27-hydroxycholesterol (27-HC) is the first known endogenous selective estrogen receptor modulator (SERM), and its elevation from normal levels is closely associated with breast cancer. A plethora of evidence suggests that aberrant epigenetic signa...
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Antibody
Androgen receptor and MYC equilibration centralizes on developmentalsuper-enhancer
Published: December, 2021
Abstract: Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin ...
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Antibody
The long noncoding RNA H19 regulates tumor plasticity inneuroendocrine prostate cancer
Published: December, 2021
Abstract: Neuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (PCa) arising either de novo or from transdifferentiated prostate adenocarcinoma following androgen deprivation therapy (ADT). Extensive computa...
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Antibody
Epigenetic Silencing of OR and TAS2R Genes Expression inHuman Orbitofrontal Cortex At Early Stages of SporadicAlzheimer’s Disease
Published: December, 2021
Abstract: Modulation of brain olfactory (OR) and taste receptors (TASR) expression was recently reported in neurological diseases. We explored the possible expression and regulation of selected OR and TASR genes in human orbitofrontal cortex of sporadic Alz...
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Antibody
Gene bookmarking by the heat shock transcription factor programs theinsulin-like signaling pathway.
Published: December, 2021
Abstract: Maternal stress can have long-lasting epigenetic effects on offspring. To examine how epigenetic changes are triggered by stress, we examined the effects of activating the universal stress-responsive heat shock transcription factor HSF-1 in the ge...
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Antibody
Epromoters function as a hub to recruit key transcription factorsrequired for the inflammatory response
Published: November, 2021
Abstract: Gene expression is controlled by the involvement of gene-proximal (promoters) and distal (enhancers) regulatory elements. Our previous results demonstrated that a subset of gene promoters, termed Epromoters, work as bona fide enhancers and regulat...
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Antibody Microplex Library Preparation kit
Comparing the epigenetic landscape in myonuclei purified with a PCM1antibody from a fast/glycolytic and a slow/oxidative muscle.
Published: November, 2021
Abstract: Muscle cells have different phenotypes adapted to different usage, and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing a genome-wide analysis of ...
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Antibody
Conditional depletion of transcriptional kinases Ctk1 and Bur1 andeffects on co-transcriptional spliceosome assembly and pre-mRNA splicing.
Published: November, 2021
Abstract: From yeast to humans, pre-mRNA splicing occurs mainly co-transcriptionally, with splicing and transcription functionally coupled such that they influence one another. The recruitment model of co-transcriptional splicing proposes that core members ...
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Antibody
ATRX regulates glial identity and the tumor microenvironment inIDH-mutant glioma
Published: November, 2021
Abstract: Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic...
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Antibody CUT&Tag
Short-Chain Fatty Acids Calibrate RARα Activity RegulatingFood Sensitization
Published: October, 2021
Abstract: Gut-microbiota dysbiosis links to allergic diseases. The mechanism of the exacerbation of food allergy caused by gut-microbiota dysbiosis remains unknown. Regulation of retinoic acid receptor alpha (RARα) signaling is critical for gut immune...
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Antibody
Rhesus macaques self-curing from a schistosome infection can displaycomplete immunity to challenge
Published: October, 2021
Abstract: The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict \>200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an establish...
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Antibody IP-Star Compact ChIPmentation
Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASRcomplex in mouse models
Published: October, 2021
Abstract: Rett syndrome (RTT) is a severe neurological disorder and a leading cause of intellectual disability in young females. RTT is mainly caused by mutations found in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). Despite extensive st...
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Antibody
SETD2-mediated epigenetic regulation of noncanonical Wnt5A duringosteoclastogenesis
Published: October, 2021
Abstract: Graphic abstract To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We found that SETD2 and WNT5...
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Antibody

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  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
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