Diagenode
| United States | My cart | ログイン / サインアップ 検索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
bESCs from cloned embryos do not retain transcriptomic or epigenetic memory from somatic donor cells.
Published: August, 2022
Abstract: Embryonic stem cells (ESC) indefinitely maintain the pluripotent state of the blastocyst epiblast. Stem cells are invaluable for studying development and lineage commitment, and in livestock they constitute a useful tool for genomic improvement an...
Read more »
Tags
Antibody
Histone lysine demethylase inhibition reprograms prostate cancermetabolism and mechanics.
Published: August, 2022
Abstract: OBJECTIVE: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, ...
Read more »
Tags
Antibody Bioruptor Plus
The Arabidopsis APOLO and human UPAT sequence-unrelated longnoncoding RNAs can modulate DNA and histone methylation machineries inplants.
Published: August, 2022
Abstract: BACKGROUND: RNA-DNA hybrid (R-loop)-associated long noncoding RNAs (lncRNAs), including the Arabidopsis lncRNA AUXIN-REGULATED PROMOTER LOOP (APOLO), are emerging as important regulators of three-dimensional chromatin conformation and gene transcr...
Read more »
Tags
Bioruptor Antibody
Histone H3K36me2 and H3K36me3 form a chromatin platform essentialfor DNMT3A-dependent DNA methylation in mouse oocytes.
Published: August, 2022
Abstract: Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes, high levels of DNA methylation occur exclusively in the transcriptionally ac...
Read more »
Tags
Antibody
Epigenetic remodeling of downstream enhancer regions is linked toselective expression of the IL1F10 gene in differentiated humankeratinocytes.
Published: August, 2022
Abstract: Interleukin (IL)-38, encoded by the IL1F10 gene, is a member of the IL-1 family of cytokines. IL-38 is constitutively expressed in epithelia in healthy humans, and in particular in epidermal keratinocytes in the skin. IL-38 expression is closely c...
Read more »
Tags
Antibody iDeal ChIP-qPCR
Prolonged FOS activity disrupts a global myogenic transcriptionalprogram by altering 3D chromatin architecture in primary muscleprogenitor cells.
Published: August, 2022
Abstract: BACKGROUND: The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FO...
Read more »
Tags
Bioruptor Antibody iDeal ChIP-qPCR
Large-scale manipulation of promoter DNA methylation revealscontext-specific transcriptional responses and stability.
Published: July, 2022
Abstract: BACKGROUND: Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous pro...
Read more »
Tags
Antibody
HOTAIR interacts with PRC2 complex regulating the regional preadipocytetranscriptome and human fat distribution.
Published: July, 2022
Abstract: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyt...
Read more »
Tags
Antibody
Embryonic heat conditioning in chicks induces transgenerationalheat/immunological resilience via methylation on regulatory elements.
Published: July, 2022
Abstract: The question of whether behavioral traits are heritable is under debate. An obstacle in demonstrating transgenerational inheritance in mammals originates from the maternal environment's effect on offspring phenotype. Here, we used in ovo embryonic...
Read more »
Tags
Antibody
Epiblast inducers capture mouse trophectoderm stem cells in vitro andpattern blastoids for implantation in utero.
Published: July, 2022
Abstract: The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an optimal set of molecules sec...
Read more »
Tags
Antibody
Nox4 promotes endothelial differentiation through chromatin remodeling.
Published: July, 2022
Abstract: RATIONALE: Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of HO. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation. The high expression of Nox4 seen in endothelial cel...
Read more »
Tags
Antibody
Systematic comparison of CRISPR-based transcriptional activatorsuncovers gene-regulatory features of enhancer-promoter interactions.
Published: July, 2022
Abstract: Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mec...
Read more »
Tags
Antibody CRISPR
Epigenomic analysis reveals a dynamic and context-specific macrophageenhancer landscape associated with innate immune activation and tolerance.
Published: June, 2022
Abstract: BACKGROUND: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endot...
Read more »
Tags
Antibody
Nuclear receptor RORγ inverse agonists/antagonists display tissue- andgene-context selectivity through distinct activities in altering chromatinaccessibility and master regulator SREBP2 occupancy.
Published: June, 2022
Abstract: The nuclear receptor RORγ is a major driver of autoimmune diseases and certain types of cancer due to its aberrant function in T helper 17 (Th17) cell differentiation and tumor cholesterol metabolism, respectively. Compound screening using t...
Read more »
Tags
Antibody
HISTONE DEACETYLASE 15 and MOS4-Associated Complex subunits3A/3B coregulate intron retention of ABA-responsive genes.
Published: June, 2022
Abstract: Histone deacetylases (HDAs) play an important role in transcriptional regulation of multiple biological processes. In this study, we investigated the function of HDA15 in abscisic acid (ABA) responses. We used immunopurification coupled with mass ...
Read more »
Tags
Antibody
NSUN2-mediated RNA mC modification modulates uveal melanoma cellproliferation and migration.
Published: June, 2022
Abstract: RNA 5-methylcytosine (mC) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological rol...
Read more »
Tags
Antibody
Caffeine intake exerts dual genome-wide effects on hippocampal metabolismand learning-dependent transcription.
Published: June, 2022
Abstract: Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumpt...
Read more »
Tags
Antibody Microplex Library Preparation kit CUT&Tag
EHF is a novel regulator of cellular redox metabolism and predictspatient prognosis in HNSCC.
Published: June, 2022
Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease with relatively high morbidity and mortality rates. The lack of effective therapies, high recurrence rates and drug resistance driven in part, by tumor heterogeneity, contrib...
Read more »
Tags
Chromatin Shearing Antibody
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p incolorectal cancer.
Published: May, 2022
Abstract: The Telomeric Repeat binding Factor 2 (TRF2), a key protein involved in telomere integrity, is over-expressed in several human cancers and promotes tumor formation and progression. Recently, TRF2 has been also found outside telomeres where it can ...
Read more »
Tags
Antibody
Developmental mRNA mC landscape and regulatory innovations of massivemC modification of maternal mRNAs in animals.
Published: May, 2022
Abstract: mC is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA mC maps at different stages of development in 6 vertebrate and inv...
Read more »
Tags
Antibody
HIRA supports hepatitis B virus minichromosome establishment andtranscriptional activity in infected hepatocytes.
Published: May, 2022
Abstract: BACKGROUND \& AIMS: Upon Hepatitis B virus (HBV) infection, partially double stranded viral DNA converts into a covalently-closed-circular chromatinized episomal structure (cccDNA). This form represents the long-lived genomic reservoir respons...
Read more »
Tags
Antibody
Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
Published: May, 2022
Abstract: BACKGROUND: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents ...
Read more »
Tags
Antibody
MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functionsin hepatocellular carcinoma by directly targeting hepatoma-derived growthfactor HDGF.
Published: May, 2022
Abstract: BACKGROUND: In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA expression is a potential tr...
Read more »
Tags
Antibody
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymaltransition
Published: May, 2022
Abstract: Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is requ...
Read more »
Tags
Antibody
Variation in PU.1 binding and chromatin looping at neutrophil enhancersinfluences autoimmune disease susceptibility
Published: May, 2022
Abstract: Neutrophils play fundamental roles in innate inflammatory response, shape adaptive immunity1, and have been identified as a potentially causal cell type underpinning genetic associations with immune system traits and diseases2,3 The majority of th...
Read more »
Tags
Antibody
Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts
Published: May, 2022
Abstract: Background/aim: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and ...
Read more »
Tags
Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Epigenetic Mechanisms Mediating Cell State Transitions in Chondrocytes
Published: May, 2022
Abstract: Epigenetic modifications play critical roles in regulating cell lineage differentiation, but the epigenetic mechanisms guiding specific differentiation steps within a cell lineage have rarely been investigated. To decipher such mechanisms, we used...
Read more »
Tags
Bioruptor Antibody Microplex Library Preparation kit True MicroChIP kit
Macrophage programming is regulated by a cooperative interaction betweenfatty acid binding protein 5 and peroxisome proliferator-activated receptorγ.
Published: May, 2022
Abstract: Resolution of inflammation is an active process that is tightly regulated to achieve repair and tissue homeostasis. In the absence of resolution, persistent inflammation underlies the pathogenesis of chronic lung disease such as chronic obstructiv...
Read more »
Tags
Antibody
Global DNA methylation and cellular 5-methylcytosine and H4acetylated patterns in primary and secondary dormant seeds of Capsellabursa-pastoris (L.) Medik. (shepherd's purse).
Published: May, 2022
Abstract: Despite the importance of dormancy and dormancy cycling for plants' fitness and life cycle phenology, a comprehensive characterization of the global and cellular epigenetic patterns across space and time in different seed dormancy states is lackin...
Read more »
Tags
Antibody
AUXIN RESPONSE FACTOR 16 (StARF16) regulates defense gene StNPR1 upon infection with necrotrophic pathogen in potato.
Published: April, 2022
Abstract: We demonstrate a new regulatory mechanism in the jasmonic acid (JA) and salicylic acid (SA) mediated crosstalk in potato defense response, wherein, miR160 target StARF16 (a gene involved in growth and development) binds to the promoter of StNPR1 (...
Read more »
Tags
Antibody Universal Plant ChIP-seq Kit

イベント

 すべてのイベントを見る

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy