Diagenode

>>>   Click for Diagenode’s approach to COVID-19

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.


Moorlag, Simone J C F M and Rodriguez-Rosales, Yessica Alina and Gillard, Joshua and Fanucchi, Stephanie and Theunissen, Kate and Novakovic, Boris and de Bont, Cynthia M and Negishi, Yutaka and Fok, Ezio T and Kalafati, Lydia and Verginis, Panayotis and M

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is unknown whether BCG vaccination also leads to functional reprogramming of mature neutrophils. Here, we show that BCG vaccination of healthy humans induces long-lasting changes in neutrophil phenotype, characterized by increased expression of activation markers and antimicrobial function. The enhanced function of human neutrophils persists for at least 3 months after vaccination and is associated with genome-wide epigenetic modifications in trimethylation at histone 3 lysine 4. Functional reprogramming of neutrophils by the induction of trained immunity might offer novel therapeutic strategies in clinical conditions that could benefit from modulation of neutrophil effector function.

Share this article

Published
November, 2020

Source

Events

 See all events

News

 See all news


The European Regional Development Fund and Wallonia are investing in your future.

Extension of industrial buildings and new laboratories.



  ABOUT SSL CERTIFICATES

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy   |   Diagenode Diagnostics