Diagenode

Workflow for FFPE-derived DNA shearing prior to Next Generation Sequencing

Formalin fixation and paraffin embedding (FFPE) is a standard method for long-term preservation of most archived pathological specimens. Archival FFPE samples provide an invaluable repository of information for genetic analysis. These samples can be analyzed by next-generation sequencing for applications including biomarker discovery, drug development, and cancer research. However, DNA from archival tissues is challenging to use in NGS studies due to insufficient quality, including degradation, chemical modifications and the presence of single-stranded molecules.

Events

  • ASHG
    Houston, TX
    Oct 15-Oct 19, 2019
  • Neuroscience 2019
    Chicago, IL
    Oct 19-Oct 23, 2019
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