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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
p300 suppresses the transition of myelodysplastic syndromes to acutemyeloid leukemia
Published: October, 2021
Abstract: Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, direc...
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Antibody
Tracing the emergence of primordial germ cells from bilaminar disc rabbitembryos and pluripotent stem cells.
Published: October, 2021
Abstract: Rabbit embryos develop as bilaminar discs at gastrulation as in humans and most other mammals, whereas rodents develop as egg cylinders. Primordial germ cells (PGCs) appear to originate during gastrulation according to many systematic studies on m...
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Antibody
NR4A1 regulates expression of immediate early genes, suppressingreplication stress in cancer.
Published: October, 2021
Abstract: Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful signals, contributing to an integrated response. Here, we find that the orphan nuclear ...
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Antibody
Regulatory interplay between Vav1, Syk and β-catenin occurs in lungcancer cells.
Published: October, 2021
Abstract: Vav1 exhibits two signal transducing properties as an adaptor protein and a regulator of cytoskeleton organization through its Guanine nucleotide Exchange Factor module. Although the expression of Vav1 is restricted to the hematopoietic lineage, i...
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Antibody iDeal ChIP-qPCR ChIP Cross-link Gold
MICAL1 regulates actin cytoskeleton organization, directional cellmigration and the growth of human breast cancer cells as orthotopicxenograft tumours.
Published: October, 2021
Abstract: The Molecule Interacting with CasL 1 (MICAL1) monooxygenase has emerged as an important regulator of cytoskeleton organization via actin oxidation. Although filamentous actin (F-actin) increases MICAL1 monooxygenase activity, hydrogen peroxide (HO...
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Antibody CRISPR
Differential contribution to gene expression prediction of histonemodifications at enhancers or promoters.
Published: September, 2021
Abstract: The ChIP-seq signal of histone modifications at promoters is a good predictor of gene expression in different cellular contexts, but whether this is also true at enhancers is not clear. To address this issue, we develop quantitative models to char...
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Antibody
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Published: September, 2021
Abstract: The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How these enzymes are regulated to mark specific genomic regions as heterochromatic is poor...
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Bioruptor Antibody
Chromosomal variations of species revealed by FISH with rDNAs andcentromeric histone H3 variant associated DNAs
Published: September, 2021
Abstract: Lycoris species have various chromosome numbers and karyotypes, but all have a constant total number of chromosome major arms. In addition to three fundamental types, including metacentric (M-), telocentric (T-), and acrocentric (A-) chromosomes, ...
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Universal Plant ChIP-seq Kit
Coordination of EZH2 and SOX2 specifies human neural fate decision.
Published: September, 2021
Abstract: Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different ...
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Antibody
Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells.
Published: September, 2021
Abstract: Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1)...
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Antibody
The prolyl-isomerase PIN1 is essential for nuclear Lamin-Bstructure and function and protects heterochromatin under mechanicalstress.
Published: September, 2021
Abstract: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including...
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Antibody
DOT1L O-GlcNAcylation promotes its protein stability andMLL-fusion leukemia cell proliferation.
Published: September, 2021
Abstract: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about ...
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Antibody
WT1 regulates HOXB9 gene expression in a bidirectional way.
Published: September, 2021
Abstract: The homeoboxB9 (HOXB9) gene is necessary for specification of the anterior-posterior body axis during embryonic development and expressed in various types of cancer. Here we show that the Wilms tumor transcription factor WT1 regulates the HOXB9 ge...
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Antibody
INTS11 regulates hematopoiesis by promoting PRC2 function.
Published: September, 2021
Abstract: INTS11, the catalytic subunit of the Integrator (INT) complex, is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs. However, the role of INTS11 in hematopoietic stem and progenitor cell (HSPC) biology is unknown. Here, we report ...
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Antibody Microplex Library Preparation kit
Histone deacetylase 4 deletion broadly affects cardiac epigeneticrepression and regulates transcriptional susceptibility via H3K9methylation.
Published: September, 2021
Abstract: Histone deacetylase 4 (HDAC4) is a member of class IIa histone deacetylases (class IIa HDACs) and is believed to possess a low intrinsic deacetylase activity. However, HDAC4 sufficiently represses distinct transcription factors (TFs) such as the m...
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IP-Star Antibody
Genome-wide and sister chromatid-resolved profiling of protein occupancyin replicated chromatin with ChOR-seq and SCAR-seq
Published: September, 2021
Abstract: Elucidating the mechanisms underlying chromatin maintenance upon genome replication is critical for the understanding of how gene expression programs and cell identity are preserved across cell divisions. Here, we describe two recently developed t...
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Antibody
Epigenetic remodelling of enhancers in response to estrogen deprivationand re-stimulation.
Published: September, 2021
Abstract: Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investig...
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Antibody iDeal ChIP-seq Kit for Histones iDeal ChIP-qPCR hMeDIP
Epigenetic control of region-specific transcriptional programs in mousecerebellar and cortical astrocytes.
Published: September, 2021
Abstract: Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensivel...
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Antibody
Activated Histone Acetyltransferase p300/CBP-Related SignallingPathways Mediate Up-Regulation of NADPH Oxidase,Inflammation, and Fibrosis in Diabetic Kidney
Published: August, 2021
Abstract: Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microvascular ...
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Antibody
Aiolos regulates eosinophil migration into tissues.
Published: August, 2021
Abstract: Expression of Ikaros family transcription factor IKZF3 (Aiolos) increases during murine eosinophil lineage commitment and maturation. Herein, we investigated Aiolos expression and function in mature human and murine eosinophils. Murine eosinophils...
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Antibody
Establishment of two homozygous CRISPR interference (CRISPRi)knock-in human induced pluripotent stem cell (hiPSC) lines for titratableendogenous gene repression.
Published: August, 2021
Abstract: Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and disease mec...
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Antibody CRISPR
Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in C. elegans
Published: August, 2021
Abstract: During meiosis, gene expression is silenced in aberrantly unsynapsed chromatin and in heterogametic sex chromosomes. Initiation of sex chromosome silencing is disrupted in meiocytes with sex chromosome-autosome translocations. To determine whether...
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Antibody
Altered Chromatin States Drive Cryptic Transcription in AgingMammalian Stem Cells.
Published: August, 2021
Abstract: A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells. Cryptic transcription is elevated with age in yeast and nematodes, and reducing i...
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Antibody Microplex Library Preparation kit True MicroChIP kit
Enhanced targeted DNA methylation of the CMV and endogenous promoterswith dCas9-DNMT3A3L entails distinct subsequent histonemodification changes in CHO cells.
Published: July, 2021
Abstract: With the emergence of new CRISPR/dCas9 tools that enable site specific modulation of DNA methylation and histone modifications, more detailed investigations of the contribution of epigenetic regulation to the precise phenotype of cells in culture,...
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Antibody iDeal ChIP-qPCR
Evidence for long-term association of virion-delivered HBV core proteinwith cccDNA independently of viral protein production
Published: July, 2021
Abstract: Background \& Aims HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis. Both HBx and HBc (core) viral proteins associate wit...
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Antibody
Phase separation drives aberrant chromatin looping and cancerdevelopment.
Published: July, 2021
Abstract: The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP...
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Antibody
ChIP-seq protocol for sperm cells and embryos to assess environmentalimpacts and epigenetic inheritance
Published: June, 2021
Abstract: In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally. We de...
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Antibody
Epigenetic inheritance of DNA methylation changes in fish living inhydrogen sulfide-rich springs.
Published: June, 2021
Abstract: Environmental factors can promote phenotypic variation through alterations in the epigenome and facilitate adaptation of an organism to the environment. Although hydrogen sulfide is toxic to most organisms, the fish has adapted to survive in envir...
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Antibody
E2F6 initiates stable epigenetic silencing of germline genes duringembryonic development
Published: June, 2021
Abstract: In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the transcription factor E2F6, a me...
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Antibody
Genome-wide CRISPR screen identifies protein pathways modulating tauprotein levels in neurons
Published: June, 2021
Abstract: Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechan...
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Antibody

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