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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×
Quantifying propagation of DNA methylation and hydroxymethylation withiDEMS.
Published: January, 2023
Abstract: DNA methylation is a critical epigenetic mark in mammalian cells. Many aspects of DNA methylation maintenance have been characterized; however, the exact kinetics of post-replicative methylation maintenance remain a subject of debate. Here we deve...
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Antibody
Role of epigenetics in the etiology of hypospadias through penileforeskin DNA methylation alterations.
Published: January, 2023
Abstract: Abnormal penile foreskin development in hypospadias is the most frequent genital malformation in male children, which has increased dramatically in recent decades. A number of environmental factors have been shown to be associated with hypospadias...
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Antibody
Gene Regulatory Interactions at Lamina-Associated Domains
Published: January, 2023
Abstract: The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How the...
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Antibody Microplex Library Preparation kit
Epigenomic charting and functional annotation of risk loci in renal cellcarcinoma.
Published: January, 2023
Abstract: While the mutational and transcriptional landscapes of renal cell carcinoma (RCC) are well-known, the epigenome is poorly understood. We characterize the epigenome of clear cell (ccRCC), papillary (pRCC), and chromophobe RCC (chRCC) by using ChIP-...
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Antibody
Auxin-inducible degron 2 system deciphers functions of CTCF domains intranscriptional regulation.
Published: January, 2023
Abstract: BACKGROUND: CTCF is a well-established chromatin architectural protein that also plays various roles in transcriptional regulation. While CTCF biology has been extensively studied, how the domains of CTCF function to regulate transcription remains...
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Antibody
Methyltransferase Inhibition Enables Tgf Driven Induction of and in Cancer Cells.
Published: January, 2023
Abstract: deletion or silencing is common across human cancer, reinforcing the general importance of bypassing its tumor suppression in cancer formation or progression. In rhabdomyosarcoma (RMS) and neuroblastoma, two common childhood cancers, the three tra...
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Antibody CRISPR
Analyzing the Genome-Wide Distribution of Histone Marks byCUT\&Tag in Drosophila Embryos.
Published: January, 2023
Abstract: CUT&Tag is a method to map the genome-wide distribution of histone modifications and some chromatin-associated proteins. CUT&Tag relies on antibody-targeted chromatin tagmentation and can easily be scaled up or automatized. This protocol p...
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Antibody
Heterocycle-containing tranylcypromine derivatives endowed with highanti-LSD1 activity.
Published: December, 2022
Abstract: As regioisomers/bioisosteres of , a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives -, in which the 4-phenyl moi...
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Antibody
Trichoderma root colonization triggers epigenetic changes in jasmonic andsalicylic acid pathway-related genes.
Published: December, 2022
Abstract: Beneficial interactions between plant-roots and Trichoderma spp. lead to a local and systemic enhancement of the plant immune system through a mechanism known as priming of defenses. In recent reports, we outlined a repertoire of genes and protein...
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Antibody
Intranasal administration of Acinetobacter lwoffii in a murine model ofasthma induces IL-6-mediated protection associated with cecal microbiotachanges.
Published: December, 2022
Abstract: BACKGROUND: Early-life exposure to certain environmental bacteria including Acinetobacter lwoffii (AL) has been implicated in protection from chronic inflammatory diseases including asthma later in life. However, the underlying mechanisms at the i...
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Antibody Microplex Library Preparation kit True MicroChIP kit
Simultaneous profiling of histone modifications and DNA methylation viananopore sequencing.
Published: December, 2022
Abstract: The interplay between histone modifications and DNA methylation drives the establishment and maintenance of the cellular epigenomic landscape, but it remains challenging to investigate the complex relationship between these epigenetic marks across...
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CUT&Tag
Consistent DNA Hypomethylations in Prostate Cancer.
Published: December, 2022
Abstract: With approximately 1.4 million men annually diagnosed with prostate cancer (PCa) worldwide, PCa remains a dreaded threat to life and source of devastating morbidity. In recent decades, a significant decrease in age-specific PCa mortality has been ...
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MagMeDIP kit Antibody
The histone acetyltransferase KAT6A is recruited to unmethylatedCpG islands via a DNA binding winged helix domain.
Published: December, 2022
Abstract: The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AM...
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Antibody Microplex Library Preparation kit
KMT2D deficiency drives lung squamous cell carcinoma andhypersensitivity to RTK-RAS inhibition.
Published: December, 2022
Abstract: Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (>20\%), and yet its role in LUSC oncogenesis remains unknown. Here, we iden...
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Antibody
K27M in canonical and noncanonical H3 variants occurs in distinctoligodendroglial cell lineages in brain midline gliomas.
Published: December, 2022
Abstract: Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and molecular profiles. The contribution of the cell of origin to these differences has been challenging to u...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
DNA sequence and chromatin modifiers cooperate to confer epigeneticbistability at imprinting control regions.
Published: November, 2022
Abstract: Genomic imprinting is regulated by parental-specific DNA methylation of imprinting control regions (ICRs). Despite an identical DNA sequence, ICRs can exist in two distinct epigenetic states that are memorized throughout unlimited cell divisions a...
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Antibody
RNA 5-Methylcytosine Modification Regulates VegetativeDevelopment Associated with H3K27 Trimethylation inArabidopsis.
Published: November, 2022
Abstract: Methylating RNA post-transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals. However,...
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Antibody
Identification of genomic binding sites and direct target genes for thetranscription factor DDIT3/CHOP.
Published: November, 2022
Abstract: DDIT3 is a tightly regulated basic leucine zipper (bZIP) transcription factor and key regulator in cellular stress responses. It is involved in a variety of pathological conditions and may cause cell cycle block and apoptosis. It is also implicate...
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Antibody IPure kit Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors Chromatin Profiling (ChIP-seq) Services
Examination of Generational Impacts of Adolescent Chemotherapy:Ifosfamide and Potential for Epigenetic TransgenerationalInheritance
Published: November, 2022
Abstract: The current study was designed to use a rodent model to determine if exposure to the chemotherapy drug ifosfamide during puberty can induce altered phenotypes and disease in the grand-offspring of exposed individuals through epigenetic transgenera...
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Antibody
Cardiac epigenetic changes in VEGF signaling genes associates with myocardial microvascular rarefaction in experimental chronic kidney disease.
Published: November, 2022
Abstract: BACKGROUND: Chronic kidney disease (CKD) is common in patients with heart failure, and often results in left ventricular diastolic dysfunction (LVDD). However, the mechanisms responsible for cardiac damage in CKD-LVDD remain to be elucidated. Epig...
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Antibody
Systematic discovery and functional dissection of enhancers needed forcancer cell fitness and proliferation.
Published: November, 2022
Abstract: A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to understanding how these cis-regulatory elements contribute to human diseases. We carry out highly multiplexed CRISPR-based perturbation and sequenc...
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Antibody
Histone Deacetylases 1 and 2 target gene regulatory networks of nephronprogenitors to control nephrogenesis.
Published: November, 2022
Abstract: Our studies demonstrated the critical role of Histone deacetylases (HDACs) in the regulation of nephrogenesis. To better understand the key pathways regulated by HDAC1/2 in early nephrogenesis, we performed chromatin immunoprecipitation sequencing...
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Antibody iDeal ChIP-seq Kit for Transcription Factors Chromatin Profiling (ChIP-seq) Services
Epigenome-wide association study of physical activity and physiologicalparameters in discordant monozygotic twins.
Published: November, 2022
Abstract: An epigenome-wide association study (EWAS) was performed on buccal cells from monozygotic-twins (MZ) reared together as children, but who live apart as adults. Cohorts of twin pairs were used to investigate associations between neighborhood walkab...
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Antibody
Balance between autophagy and cell death is maintained byPolycomb-mediated regulation during stem cell differentiation.
Published: November, 2022
Abstract: Autophagy is a conserved cytoprotective process, aberrations in which lead to numerous degenerative disorders. While the cytoplasmic components of autophagy have been extensively studied, the epigenetic regulation of autophagy genes, especially in...
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Bioruptor Antibody
Estrone, the major postmenopausal estrogen, binds ERa to induceSNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancermetastasis.
Published: November, 2022
Abstract: Recent work showed that the dominant post-menopausal estrogen, estrone, cooperates with nuclear factor κB (NF-κB) to stimulate inflammation, while pre-menopausal 17β-estradiol opposes NF-κB. Here, we show that post-menopausa...
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Antibody
Dietary methionine starvation impairs acute myeloid leukemia progression.
Published: November, 2022
Abstract: Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with acute myeloid leukemia (AML). An amino acid dropout screen on primary leukemic stem cells and progenitor populations revealed a number of amino acid ...
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Antibody
Efficacy of selective histone deacetylase 6 inhibition in mouse models ofPseudomonas aeruginosa infection: A new glimpse for reducinginflammation and infection in cystic fibrosis.
Published: October, 2022
Abstract: The latest studies identified the histone deacetylase (HDAC) class of enzymes as strategic components of the complex molecular machinery underlying inflammation in cystic fibrosis (CF). Compelling new support has been provided for HDAC6 isoform as...
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Antibody
The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy.
Published: October, 2022
Abstract: TERF2/TRF2 is a pleiotropic telomeric protein that plays a crucial role in tumor formation and progression through several telomere-dependent and -independent mechanisms. Here, we uncovered a novel function for this protein in regulating the macro...
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Antibody
Systems-biology analysis of rheumatoid arthritis fibroblast-likesynoviocytes implicates cell line-specific transcription factor function.
Published: October, 2022
Abstract: Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that remains an unmet medical need despite improved therapy. This limitation likely reflects the diversity of pathogenic pathways in RA, with individual patients...
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Antibody
Viral transduction of primary human lymphoma B cells reveals mechanismsof NOTCH-mediated immune escape.
Published: October, 2022
Abstract: Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells from patients with C...
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Antibody

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