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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
Single-cell m6A mapping in vivo using picoMeRIP-seq
Published: June, 2023
Abstract: Current N-methyladenosine (mA) mapping methods need large amounts of RNA or are limited to cultured cells. Through optimized sample recovery and signal-to-noise ratio, we developed picogram-scale mA RNA immunoprecipitation and sequencing (picoMeRI...
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Antibody
NUP98 and RAE1 sustain progenitor function through HDAC-dependentchromatin targeting to escape from nucleolar localization.
Published: June, 2023
Abstract: Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor function remains incompletely understood. Here we show that NUP98 and RAE1 are highly expressed in ...
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Antibody
Bioengineering novel AAV9-mGULO-GT for multi-disease gene therapy:Targeting mutated GULO expression to cure scurvy and brain diseases.
Published: June, 2023
Abstract: Current clinical breakthroughs in gene therapy have brought adeno-associated virus (AAV) vectors to the forefront of gene delivery systems. Vitamin C deficiency due to GULO mutations is a genetic disorder affecting guinea pigs and humans. In our s...
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Antibody
In skeletal muscle and neural crest cells, SMCHD1 regulates biologicalpathways relevant for Bosma syndrome and facioscapulohumeral dystrophyphenotype.
Published: June, 2023
Abstract: Many genetic syndromes are linked to mutations in genes encoding factors that guide chromatin organization. Among them, several distinct rare genetic diseases are linked to mutations in SMCHD1 that encodes the structural maintenance of chromosomes...
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Antibody iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones Infinium Human MethylationEPIC Array Service
Vitamin D Receptor Cross-talk with p63 Signaling PromotesEpidermal Cell Fate.
Published: June, 2023
Abstract: The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D (1,25D) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this stud...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Mu opioid receptor expressing neurons in the rostral ventromedial medullaare the source of mechanical hypersensitivity induced by repeated restraintstress.
Published: June, 2023
Abstract: Repeated exposure to psychophysical stress often causes an increase in sensitivity and response to pain. This phenomenon is commonly called stress-induced hyperalgesia (SIH). Although psychophysical stress is a well-known risk factor for numerous ...
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Antibody
SALL1 enforces microglia-specific DNA binding and function of SMADsto establish microglia identity.
Published: June, 2023
Abstract: Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with the Sall1 promoter results in complete...
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Antibody
Sexual differentiation in human malaria parasites is regulated bycompetition between phospholipid metabolism and histone methylation.
Published: June, 2023
Abstract: For Plasmodium falciparum, the most widespread and virulent malaria parasite that infects humans, persistence depends on continuous asexual replication in red blood cells, while transmission to their mosquito vector requires asexual blood-stage pa...
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Antibody
Identification of a deltaNp63-Dependent Basal-Like ASubtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.
Published: June, 2023
Abstract: A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therapy for defined molecular subtypes. In this work, we sought to gain further insight and identify molec...
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Antibody
Hypomethylation and overexpression of Th17-associated genes is ahallmark of intestinal CD4+ lymphocytes in Crohn's disease.
Published: June, 2023
Abstract: BACKGROUND: The development of Crohn's disease (CD) involves immune cell signaling pathways regulated by epigenetic modifications. Aberrant DNA methylation has been identified in peripheral blood and bulk intestinal tissue from CD patients. Howeve...
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Antibody Microplex Library Preparation kit
Mutant FUS induces chromatin reorganization in the hippocampus andalters memory processes.
Published: June, 2023
Abstract: Cytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS accumulation is recapitulated in the frontal cortex and spinal cord o...
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Antibody Microplex Library Preparation kit ChIP Cross-link Gold
Pathologic HDAC1/c-Myc signaling axis is responsible forangiotensinogen transcription and hypertension induced by high-fat diet.
Published: May, 2023
Abstract: High-fat diet (HFD)-induced obesity is a cause of resistant hypertension. We have shown a possible link between histone deacetylases (HDACs) and renal angiotensinogen (Agt) upregulation in the HFD-induced hypertension, whereas the underlying mecha...
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Antibody
The circadian clock CRY1 regulates pluripotent stem cell identity andsomatic cell reprogramming.
Published: May, 2023
Abstract: Distinct metabolic conditions rewire circadian-clock-controlled signaling pathways leading to the de novo construction of signal transduction networks. However, it remains unclear whether metabolic hallmarks unique to pluripotent stem cells (PSCs)...
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Antibody
The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cellfate.
Published: May, 2023
Abstract: Placental development relies on coordinated cell fate decisions governed by signalling inputs. However, little is known about how signalling cues are transformed into repressive mechanisms triggering lineage-specific transcriptional signatures. He...
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Antibody
RUNX1 colludes with NOTCH1 to reprogram chromatin in T-cell acutelymphoblastic leukemia
Published: May, 2023
Abstract: Runt-related transcription factor 1 (RUNX1) is oncogenic in diverse types of leukemia and epithelial cancers where its expression is associated with poor prognosis. Current models suggest that RUNX1 cooperates with other oncogenic factors (e.g., N...
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Antibody
Landscape of prostate-specific membrane antigen heterogeneity andregulation in AR-positive and AR-negative metastatic prostate cancer.
Published: April, 2023
Abstract: Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15-20\% of men with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain poorly defined. In androgen receptor (AR)-positive CRPC, we observed low...
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Antibody
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene bodymethylation and hydroxymethylation marks in diabetic heart.
Published: April, 2023
Abstract: BACKGROUND: Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling ...
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MagMeDIP kit Antibody hMeDIP
Comprehensive epigenomic profiling reveals the extent of disease-specificchromatin states and informs target discovery in ankylosing spondylitis
Published: April, 2023
Abstract: Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functio...
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Antibody
A kinesin-based approach for inducing chromosome-specific mis-segregationin human cells.
Published: April, 2023
Abstract: Various cancer types exhibit characteristic and recurrent aneuploidy patterns. The origins of these cancer type-specific karyotypes are still unknown, partly because introducing or eliminating specific chromosomes in human cells still poses a chal...
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Antibody CRISPR
Farrerol directly activates the deubiqutinase UCHL3 to promote DNArepair and reprogramming when mediated by somatic cell nuclear transfer.
Published: April, 2023
Abstract: Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve genome-editing efficiency, but the specific protein that farrerol directly targets to regulate HR repair and the underlying molecular mechanisms have not been ...
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Antibody
The Effect of Metformin and Carbohydrate-Controlled Diet onDNA Methylation and Gene Expression in the Endometrium of Womenwith Polycystic Ovary Syndrome.
Published: April, 2023
Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disease associated with infertility and metabolic disorders in reproductive-aged women. In this study, we evaluated the expression of eight genes related to endometrial function and their DNA methyl...
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Bioruptor Antibody
Distinct regulation of EZH2 and its repressive H3K27me3 mark inPolyomavirus -positive and -negative Merkel cell carcinoma.
Published: April, 2023
Abstract: Merkel cell carcinoma (MCC) is an aggressive skin cancer for which Merkel cell polyomavirus (MCPyV) integration and expression of viral oncogenes small T and Large T have been identified as major oncogenic determinants. Recently, a component of th...
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Antibody
PBRM1-deficient PBAF complexes target aberrant genomic loci to activatethe NF-κB pathway in clear cell renal cell carcinoma.
Published: April, 2023
Abstract: PBRM1 encodes an accessory subunit of the PBAF SWI/SNF chromatin remodeller, and the inactivation of PBRM1 is a frequent event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodelling is not well examined. Here we show that, in...
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Antibody
Integrated analysis from multicentre studies identities RNAmethylation- related lncRNA risk stratification systems for glioma
Published: March, 2023
Abstract: Gastric cancer (GC) is the fourth leading cause of cancer death worldwide. Due to the lack of effective chemotherapy methods for advanced gastric cancer and poor prognosis, the emergence of immunotherapy has brought new hope to gastric cancer. Fur...
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Antibody
Chromatin profiling identifies transcriptional readthrough as a conservedmechanism for piRNA biogenesis in mosquitoes.
Published: March, 2023
Abstract: The piRNA pathway in mosquitoes differs substantially from other model organisms, with an expanded PIWI gene family and functions in antiviral defense. Here, we define core piRNA clusters as genomic loci that show ubiquitous piRNA expression in bo...
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Antibody
Epigenetic dosage identifies two major and functionally distinct beta cells ubtypes.
Published: March, 2023
Abstract: The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here, we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (beta HI and beta LO). Beta HI cells exhibit 4-fold higher...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Comprehensive molecular phenotyping of -deficient gastric cancer revealspervasive epigenomic reprogramming and therapeutic opportunities.
Published: March, 2023
Abstract: OBJECTIVE: Gastric cancer (GC) is a leading cause of cancer mortality, with being the second most frequently mutated driver gene in GC. We sought to decipher -specific GC regulatory networks and examine therapeutic vulnerabilities arising from los...
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Antibody
Single substitution in H3.3G34 alters DNMT3A recruitment to causeprogressive neurodegeneration.
Published: March, 2023
Abstract: Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain development, we generated H3.3G34R/V/W knock-in mice and identified strikingly distinct...
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Antibody
The RNA m5C Methylase NSUN2 Modulates Corneal EpithelialWound Healing.
Published: March, 2023
Abstract: PURPOSE: The emerging epitranscriptomics offers insights into the physiopathological roles of various RNA modifications. The RNA methylase NOP2/Sun domain family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modification of mRNAs. However, the...
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Antibody
Low affinity CTCF binding drives transcriptional regulation whereashigh affinity binding encompasses architectural functions
Published: February, 2023
Abstract: CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS). Using a conditional mous...
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Antibody iDeal ChIP-seq Kit for Transcription Factors

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