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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene bodymethylation and hydroxymethylation marks in diabetic heart.
Published: April, 2023
Abstract: BACKGROUND: Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling ...
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MagMeDIP kit Antibody hMeDIP
Comprehensive epigenomic profiling reveals the extent of disease-specificchromatin states and informs target discovery in ankylosing spondylitis
Published: April, 2023
Abstract: Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functio...
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Antibody
A kinesin-based approach for inducing chromosome-specific mis-segregationin human cells.
Published: April, 2023
Abstract: Various cancer types exhibit characteristic and recurrent aneuploidy patterns. The origins of these cancer type-specific karyotypes are still unknown, partly because introducing or eliminating specific chromosomes in human cells still poses a chal...
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Antibody CRISPR
Farrerol directly activates the deubiqutinase UCHL3 to promote DNArepair and reprogramming when mediated by somatic cell nuclear transfer.
Published: April, 2023
Abstract: Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve genome-editing efficiency, but the specific protein that farrerol directly targets to regulate HR repair and the underlying molecular mechanisms have not been ...
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Antibody
The Effect of Metformin and Carbohydrate-Controlled Diet onDNA Methylation and Gene Expression in the Endometrium of Womenwith Polycystic Ovary Syndrome.
Published: April, 2023
Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disease associated with infertility and metabolic disorders in reproductive-aged women. In this study, we evaluated the expression of eight genes related to endometrial function and their DNA methyl...
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Bioruptor Antibody
Distinct regulation of EZH2 and its repressive H3K27me3 mark inPolyomavirus -positive and -negative Merkel cell carcinoma.
Published: April, 2023
Abstract: Merkel cell carcinoma (MCC) is an aggressive skin cancer for which Merkel cell polyomavirus (MCPyV) integration and expression of viral oncogenes small T and Large T have been identified as major oncogenic determinants. Recently, a component of th...
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Antibody
PBRM1-deficient PBAF complexes target aberrant genomic loci to activatethe NF-κB pathway in clear cell renal cell carcinoma.
Published: April, 2023
Abstract: PBRM1 encodes an accessory subunit of the PBAF SWI/SNF chromatin remodeller, and the inactivation of PBRM1 is a frequent event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodelling is not well examined. Here we show that, in...
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Antibody
Integrated analysis from multicentre studies identities RNAmethylation- related lncRNA risk stratification systems for glioma
Published: March, 2023
Abstract: Gastric cancer (GC) is the fourth leading cause of cancer death worldwide. Due to the lack of effective chemotherapy methods for advanced gastric cancer and poor prognosis, the emergence of immunotherapy has brought new hope to gastric cancer. Fur...
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Antibody
Chromatin profiling identifies transcriptional readthrough as a conservedmechanism for piRNA biogenesis in mosquitoes.
Published: March, 2023
Abstract: The piRNA pathway in mosquitoes differs substantially from other model organisms, with an expanded PIWI gene family and functions in antiviral defense. Here, we define core piRNA clusters as genomic loci that show ubiquitous piRNA expression in bo...
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Antibody
Epigenetic dosage identifies two major and functionally distinct beta cells ubtypes.
Published: March, 2023
Abstract: The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here, we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (beta HI and beta LO). Beta HI cells exhibit 4-fold higher...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Comprehensive molecular phenotyping of -deficient gastric cancer revealspervasive epigenomic reprogramming and therapeutic opportunities.
Published: March, 2023
Abstract: OBJECTIVE: Gastric cancer (GC) is a leading cause of cancer mortality, with being the second most frequently mutated driver gene in GC. We sought to decipher -specific GC regulatory networks and examine therapeutic vulnerabilities arising from los...
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Antibody
Single substitution in H3.3G34 alters DNMT3A recruitment to causeprogressive neurodegeneration.
Published: March, 2023
Abstract: Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain development, we generated H3.3G34R/V/W knock-in mice and identified strikingly distinct...
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Antibody
The RNA m5C Methylase NSUN2 Modulates Corneal EpithelialWound Healing.
Published: March, 2023
Abstract: PURPOSE: The emerging epitranscriptomics offers insights into the physiopathological roles of various RNA modifications. The RNA methylase NOP2/Sun domain family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modification of mRNAs. However, the...
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Antibody
Low affinity CTCF binding drives transcriptional regulation whereashigh affinity binding encompasses architectural functions
Published: February, 2023
Abstract: CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS). Using a conditional mous...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Targeting high glucose-induced epigenetic modifications at cardiac level:the role of SGLT2 and SGLT2 inhibitors.
Published: February, 2023
Abstract: BACKGROUND: Sodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of action have been identified. However, no data on their capability to act via epigenetic mechani...
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Antibody
Myelodysplastic Syndrome associated TET2 mutations affect NK cellfunction and genome methylation.
Published: February, 2023
Abstract: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to somatic mutations, notably in the epigenetic regulator TET2. Natural Killer (NK) cel...
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Antibody Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Species-specific regulation of XIST by the JPX/FTX orthologs.
Published: February, 2023
Abstract: X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolv...
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Antibody
Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 inAlzheimer's disease.
Published: February, 2023
Abstract: Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer's disease (AD) may be the mechanism relating age-related metabolic disorders to dementia. Since Igf2 is an imprinted gene, we examined age and sex differences in the relationship betw...
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Antibody
Detailed molecular and epigenetic characterization of the Pig IPECJ2and Chicken SL-29 cell lines
Published: February, 2023
Abstract: The pig IPECJ2 and chicken SL-29 cell lines are of interest because of their untransformed nature and wide use in functional studies. Molecular characterization of these cell lines is important to gain insight into possible molecular aberrations. ...
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Antibody
Cotranscriptional demethylation induces global loss of H3K4me2 fromactive genes in Arabidopsis
Published: February, 2023
Abstract: Based on studies of animals and yeasts, methylation of histone H3 lysine 4 (H3K4me1/2/3, for mono-, di-, and tri-methylation, respectively) is regarded as the key epigenetic modification of transcriptionally active genes. In plants, however, H3K4m...
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Antibody
Histone remodeling reflects conserved mechanisms of bovine and humanpreimplantation development.
Published: February, 2023
Abstract: How histone modifications regulate changes in gene expression during preimplantation development in any species remains poorly understood. Using CUT\&Tag to overcome limiting amounts of biological material, we profiled two activating (H3K4me3 ...
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Antibody
Epigenetic regulation of plastin 3 expression by the macrosatelliteDXZ4 and the transcriptional regulator CHD4.
Published: February, 2023
Abstract: Dysregulated Plastin 3 (PLS3) levels associate with a wide range of skeletal and neuromuscular disorders and the most common types of solid and hematopoietic cancer. Most importantly, PLS3 overexpression protects against spinal muscular atrophy. D...
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Antibody iDeal ChIP-qPCR
Signal-induced enhancer activation requires Ku70 to readtopoisomerase1-DNA covalent complexes.
Published: February, 2023
Abstract: Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topoisomerase...
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Antibody
Methylation and expression of glucocorticoid receptor exon-1 variants andFKBP5 in teenage suicide-completers.
Published: February, 2023
Abstract: A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the ...
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MagMeDIP kit Antibody hMeDIP
Bridging biological cfDNA features and machine learning approaches.
Published: February, 2023
Abstract: Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to revolutionize precision oncology and blood-based cancer screening. Recent technological improvements, in combination with the ever-growing understanding of ce...
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MagMeDIP kit Antibody
Temporal modification of H3K9/14ac and H3K4me3 histone marksmediates mechano-responsive gene expression during the accommodationprocess in poplar
Published: February, 2023
Abstract: Plants can attenuate their molecular response to repetitive mechanical stimulation as a function of their mechanical history. For instance, a single bending of stem is sufficient to attenuate the gene expression in poplar plants to the subsequent ...
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Antibody Universal Plant ChIP-seq Kit
Incomplete transcriptional dosage compensation of vertebrate sexchromosomes is balanced by post-transcriptional compensation
Published: February, 2023
Abstract: Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. How...
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Antibody
Gene body DNA hydroxymethylation restricts the magnitude oftranscriptional changes during aging.
Published: February, 2023
Abstract: DNA hydroxymethylation (5hmC) is the most abundant oxidative derivative of DNA methylation (5mC) and is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been ...
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MagMeDIP kit Antibody hMeDIP
The age of bone marrow dictates the clonality of smooth muscle-derivedcells in atherosclerotic plaques.
Published: January, 2023
Abstract: Aging is the predominant risk factor for atherosclerosis, the leading cause of death. Rare smooth muscle cell (SMC) progenitors clonally expand giving rise to up to ~70\% of atherosclerotic plaque cells; however, the effect of age on SMC clonality...
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Antibody hMeDIP
DNA dioxygenases Tet2/3 regulate gene promoter accessibility andchromatin topology in lineage-specific loci to control epithelialdifferentiation.
Published: January, 2023
Abstract: Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes, catalyzing 5-methylcytosine oxidation in DNA. Here, by using --driven ablation of g...
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Antibody

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