Diagenode
| United States | My cart | 登录 / 注册 搜索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.
Published: November, 2019
Abstract: Spatially and functionally distinct domains of heterochromatin and euchromatin play important roles in the maintenance of chromosome stability and regulation of gene expression, but a comprehensive knowledge of their composition is lacking. Here, ...
Read more »
Tags
Antibody
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Published: November, 2019
Abstract: Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver organoids that r...
Read more »
Tags
Antibody LowCell ChIP kit IPure kit
Methionine metabolism in health and cancer: a nexus of diet and precisionmedicine.
Published: November, 2019
Abstract: Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these fu...
Read more »
Tags
Antibody IP-Star Compact
Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations
Published: October, 2019
Abstract: Epigenetic transgenerational inheritance potentially impacts disease etiology, phenotypic variation, and evolution. An increasing number of environmental factors from nutrition to toxicants have been shown to promote the epigenetic transgeneration...
Read more »
Tags
Antibody
The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
Published: October, 2019
Abstract: Notwithstanding the positive clinical impact of endocrine therapies in estrogen receptor-alpha (ERα)-positive breast cancer, de novo and acquired resistance limits the therapeutic lifespan of existing drugs. Taking the position that resistan...
Read more »
Tags
Antibody
TET2 Regulates the Neuroinflammatory Response in Microglia.
Published: October, 2019
Abstract: Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflammatory ...
Read more »
Tags
Antibody
Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.
Published: October, 2019
Abstract: The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss...
Read more »
Tags
Antibody
CURLY LEAF regulates micro RNA activity by controlling ARGONAUTE 1 degradation in plants.
Published: October, 2019
Abstract: CURLY LEAF (CLF) encodes the methyl-transferase sub-unit of the Polycomb Repressor Complex 2 (PRC2), which regulates the expression of target genes through H3K27 tri-methylation. We isolated a new CLF mutant allele (clf-78) using a genetic screeni...
Read more »
Tags
Antibody
Epigenomic signatures underpin the axonal regenerative ability of dorsal root ganglia sensory neurons.
Published: October, 2019
Abstract: Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenera...
Read more »
Tags
Antibody
Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms.
Published: October, 2019
Abstract: In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene dere...
Read more »
Tags
Antibody
Assaying epigenome functions of PRMTs and their substrates.
Published: September, 2019
Abstract: Among the widespread and increasing number of identified post-translational modifications (PTMs), arginine methylation is catalyzed by the protein arginine methyltransferases (PRMTs) and regulates fundamental processes in cells, such as gene regul...
Read more »
Tags
Antibody
RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.
Published: September, 2019
Abstract: Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hem...
Read more »
Tags
Antibody
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Published: September, 2019
Abstract: Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in ...
Read more »
Tags
Antibody
Functional analyses of a low-penetrance risk variant rs6702619/1p21.2 associating with colorectal cancer in Polish population.
Published: September, 2019
Abstract: Several studies employed the genome-wide association (GWA) analysis of single-nucleotide polymorphisms (SNPs) to identify susceptibility regions in colorectal cancer (CRC). However, the functional studies exploring the role of associating SNPs wit...
Read more »
Tags
Antibody
Relationship between osteoporosis and osteoarthritis based on DNA methylation
Published: September, 2019
Abstract: : The aim of this study was to investigate the relationship between osteoporosis and osteoarthritis by analyzing the DNA methylation in osteoporosis and osteoarthritis. The cancellous bone specimens were collected from a total of 12 hospitalized p...
Read more »
Tags
Antibody
Improved double-nicking strategies for COL7A1 editing by homologous recombination
Published: September, 2019
Abstract: Current gene editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin disease, suffer from low efficiencies and safety concerns that complicate implementation in clinical s...
Read more »
Tags
Antibody
Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination.
Published: September, 2019
Abstract: Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin disease, suffer from low efficiencies and safety concerns that complicate implementation in clinical s...
Read more »
Tags
Antibody
β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32.
Published: September, 2019
Abstract: American tegumentary leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoans. Innate immune cells undergo long-term functional reprogramming in response to infection or Bacillus Calmette-Guérin (BCG) vaccination vi...
Read more »
Tags
Antibody
Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma.
Published: September, 2019
Abstract: Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite extensive genetic and genomic characterization, targeted therapeutics and diagnostic markers of HNSCC a...
Read more »
Tags
Antibody IP-Star Compact
Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA.
Published: August, 2019
Abstract: Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA as a liquid biopsy tool has been gaining prominence due to the pr...
Read more »
Tags
MagMeDIP kit Antibody IPure kit
BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response.
Published: August, 2019
Abstract: Therapeutic strategies aiming to leverage anti-tumor immunity are being intensively investigated as they show promising results in cancer therapy. The PD-1/PD-L1 pathway constitutes an important target to restore functional anti-tumor immune respo...
Read more »
Tags
Antibody
Nucleome Dynamics during Retinal Development.
Published: August, 2019
Abstract: More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
Silencing of tumor-suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency.
Published: August, 2019
Abstract: Dysregulation of the epigenetic status of long noncoding RNAs (lncRNAs) has been linked to diverse human diseases including human cancers. However, the landscape of the whole-genome methylation profile of lncRNAs and the precise roles of these lnc...
Read more »
Tags
Antibody
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.
Published: August, 2019
Abstract: Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respective...
Read more »
Tags
Antibody
Epitranscriptomic Addition of mC to HIV-1 Transcripts Regulates Viral Gene Expression.
Published: August, 2019
Abstract: How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the difficulty of quantifying these modifications. Using purified HIV-1 genomic RNA, we sh...
Read more »
Tags
Antibody
Free heme regulates placenta growth factor through NRF2-antioxidant response signaling.
Published: August, 2019
Abstract: Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of PlGF have been associated in experimental animals and in patients with sickle cell disease...
Read more »
Tags
Antibody
Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation.
Published: August, 2019
Abstract: Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor ...
Read more »
Tags
Antibody
Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.
Published: August, 2019
Abstract: The genome is organized in three-dimensional units called topologically associating domains (TADs), through a process dependent on the cooperative action of cohesin and the DNA-binding factor CTCF. Genomic rearrangements of TADs have been shown to...
Read more »
Tags
Antibody
Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors.
Published: July, 2019
Abstract: DNA methylation contributes to the maintenance of genomic integrity in somatic cells, in part through the silencing of transposable elements. In this study, we use CRISPR-Cas9 technology to delete DNMT1, the DNA methyltransferase key for DNA methy...
Read more »
Tags
Antibody
Class I TCP transcription factors target the gibberellin biosynthesis gene GA20ox1 and the growth promoting genes HBI1 and PRE6 during thermomorphogenic growth in Arabidopsis.
Published: July, 2019
Abstract: Plants respond to a rise in ambient temperature by increasing the growth of petioles and hypocotyls. In this work, we show that Arabidopsis thaliana class I TEOSINTE BRANCHED 1, CYCLOIDEA, PCF (TCP) transcription factors TCP14 and TCP15 are requir...
Read more »
Tags
Antibody

活动

  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
 查看所有活动

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy