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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Cell-specific alterations inPitx1regulatory landscape activation caused bythe loss of a single enhancer
Published: March, 2021
Abstract: Most developmental genes rely on multiple transcriptional enhancers for their accurate expression during embryogenesis. Because enhancers may have partially redundant activities, the loss of one of them often leads to a partial loss of gene expres...
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Antibody
Transgenic mice for in vivo epigenome editing with CRISPR-based systems
Published: March, 2021
Abstract: The discovery, characterization, and adaptation of the RNA-guided clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 system has greatly increased the ease with which genome and epigenome editing can be performed. Fusion of chr...
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Antibody CRISPR
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic StemCells.
Published: March, 2021
Abstract: A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). However, it remains elusive whether 2C-like cells and 2C embryos share similar epigenetic features. Here, we map the genome-wide ...
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Epigenomic tensor predicts disease subtypes and reveals constrained tumorevolution.
Published: March, 2021
Abstract: Understanding the epigenomic evolution and specificity of disease subtypes from complex patient data remains a major biomedical problem. We here present DeCET (decomposition and classification of epigenomic tensors), an integrative computational a...
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Transcriptional programming drives Ibrutinib-resistance evolution in mantlecell lymphoma.
Published: March, 2021
Abstract: Ibrutinib, a bruton's tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patients relapse with lethal Ibrutinib-resistant (IR) disease. Here, using genomic, chemical proteomic, an...
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A regulatory variant at 3q21.1 confers an increased pleiotropic risk forhyperglycemia and altered bone mineral density.
Published: March, 2021
Abstract: Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density a...
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Functional annotations of three domestic animal genomes provide vitalresources for comparative and agricultural research.
Published: March, 2021
Abstract: Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex traits. The Functional Annotation of Animal Genomes consortium was formed to collaboratively annotat...
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Antibody iDeal ChIP-seq Kit for Histones
Histone modification dynamics at H3K27 are associated with alteredtranscription of in planta induced genes in Magnaporthe oryzae.
Published: February, 2021
Abstract: Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly understood. One such example is fungal plant pathogens, which use secreted proteins and small molecules...
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Antibody IPure kit
The histone modification H3K4me3 is altered at the locus in Alzheimer'sdisease brain.
Published: February, 2021
Abstract: Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined histone modifications in the disease. We use ...
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REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERICMODULATOR
Published: February, 2021
Abstract: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulati...
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Germline activity of the heat shock factor HSF-1 programs theinsulin-receptor daf-2 in C. elegans
Published: February, 2021
Abstract: The mechanisms by which maternal stress alters offspring phenotypes remain poorly understood. Here we report that the heat shock transcription factor HSF-1, activated in the C. elegans maternal germline upon stress, epigenetically programs the ins...
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The G2-phase enriched lncRNA SNHG26 is necessary for proper cell cycleprogression and proliferation
Published: February, 2021
Abstract: Long noncoding RNAs (lncRNAs) are involved in the regulation of cell cycle, although only a few have been functionally characterized. By combining RNA sequencing and ChIP sequencing of cell cycle synchronized HaCaT cells we have previously identif...
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STAG proteins promote cohesin ring loading at R-loops
Published: February, 2021
Abstract: Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not ...
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Restricted nucleation and piRNA-mediated establishment of heterochromatinduring embryogenesis in Drosophila miranda
Published: February, 2021
Abstract: Heterochromatin is a key architectural feature of eukaryotic genomes, crucial for silencing of repetitive elements and maintaining genome stability. Heterochromatin shows stereotypical enrichment patterns around centromeres and repetitive sequence...
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The epigenetic landscape in purified myonuclei from fast and slow muscles
Published: February, 2021
Abstract: Muscle cells have different phenotypes adapted to different usage and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing a genome-wide analysis of c...
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Environmental enrichment induces epigenomic and genome organization changesrelevant for cognitive function
Published: February, 2021
Abstract: In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organ...
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Chromatin dysregulation associated with NSD1 mutation in head and necksquamous cell carcinoma.
Published: February, 2021
Abstract: Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the histon...
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Antibody Bioruptor Plus IP-Star Compact
Kmt2c mutations enhance HSC self-renewal capacity and convey a selectiveadvantage after chemotherapy.
Published: February, 2021
Abstract: The myeloid tumor suppressor KMT2C is recurrently deleted in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly therapy-related MDS/AML (t-MDS/t-AML), as part of larger chromosome 7 deletions. Here, we show that KMT2C de...
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The glucocorticoid receptor recruits the COMPASS complex to regulateinflammatory transcription at macrophage enhancers.
Published: February, 2021
Abstract: Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell type...
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A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia
Published: January, 2021
Abstract: Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-...
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Antibody IP-Star Compact
Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination.
Published: January, 2021
Abstract: BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intravenous ...
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The Essential Function of SETDB1 in Homologous Chromosome Pairing andSynapsis during Meiosis.
Published: January, 2021
Abstract: SETDB1 is a histone-lysine N-methyltransferase critical for germline development. However, its function in early meiotic prophase I remains unknown. Here, we report that Setdb1 null spermatocytes display aberrant centromere clustering during lepto...
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Detection of genetic variation and base modifications at base-pairresolution on both DNA and RNA.
Published: January, 2021
Abstract: Accurate decoding of nucleic acid variation is critical to understand the complexity and regulation of genome function. Here we use a single-molecule magnetic tweezer (MT) platform to identify sequence variation and map a range of important epigen...
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Antibody
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.
Published: January, 2021
Abstract: HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are n...
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Postoperative abdominal sepsis induces selective and persistent changes inCTCF binding within the MHC-II region of human monocytes.
Published: January, 2021
Abstract: BACKGROUND: Postoperative abdominal infections belong to the most common triggers of sepsis and septic shock in intensive care units worldwide. While monocytes play a central role in mediating the initial host response to infections, sepsis-induce...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones
The tropical coral displays an unusual chromatin structure and showshistone H3 clipping plasticity upon bleaching.
Published: January, 2021
Abstract: is a hermatypic coral with strong ecological importance. Anthropogenic disturbances and global warming are major threats that can induce coral bleaching, the disruption of the mutualistic symbiosis between the coral host and its endosymbiotic alga...
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Induction of epithelial-mesenchymal transition (EMT) by hypoxia-inducedlncRNA through regulating the histone 4 lysine 16 acetylation(H4K16Ac) mark.
Published: January, 2021
Abstract: Hypoxia activates various long noncoding RNAs (lncRNAs) to induce the epithelial-mesenchymal transition (EMT) and tumor metastasis. The hypoxia/HIF-1α-regulated lncRNAs that also regulate a specific histone mark and promote EMT and metastasi...
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Chitosan nano-vehicles as biocompatible delivering tools for a newAg(I)curcuminoid-Gboxin analog complex in cancer and inflammation therapy
Published: December, 2020
Abstract: A novel anticancer and anti-inflammatory agent based on hybrid curcuminoid-Gboxin analog (FLLL49-GbA) and its macromolecular silver(I) complex (Ag(I)FLLL49-GbA) have successfully synthesized. In addition, chitosan nanoparticles (CNPs) were used to...
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Incretin drugs effect on epigenetic machinery: New potential therapeuticimplications in preventing vascular diabetic complications.
Published: December, 2020
Abstract: The effect of GLP-1R agonists on DNA methylation levels of NF-κB and SOD2 genes in human aortic endothelial cells exposed to high glucose and in diabetic patients treated and not with incretin-based drugs, was evaluated. Methylation levels, ...
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WAPL maintains a cohesin loading cycle to preserve cell-type-specificdistal gene regulation.
Published: December, 2020
Abstract: The cohesin complex has an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known a...
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Antibody Bioruptor Plus

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