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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Global DNA methylation and cellular 5-methylcytosine and H4acetylated patterns in primary and secondary dormant seeds of Capsellabursa-pastoris (L.) Medik. (shepherd's purse).
Published: May, 2022
Abstract: Despite the importance of dormancy and dormancy cycling for plants' fitness and life cycle phenology, a comprehensive characterization of the global and cellular epigenetic patterns across space and time in different seed dormancy states is lackin...
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Antibody
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p incolorectal cancer.
Published: May, 2022
Abstract: The Telomeric Repeat binding Factor 2 (TRF2), a key protein involved in telomere integrity, is over-expressed in several human cancers and promotes tumor formation and progression. Recently, TRF2 has been also found outside telomeres where it can ...
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Antibody
Developmental mRNA mC landscape and regulatory innovations of massivemC modification of maternal mRNAs in animals.
Published: May, 2022
Abstract: mC is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA mC maps at different stages of development in 6 vertebrate and inv...
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Antibody
HIRA supports hepatitis B virus minichromosome establishment andtranscriptional activity in infected hepatocytes.
Published: May, 2022
Abstract: BACKGROUND \& AIMS: Upon Hepatitis B virus (HBV) infection, partially double stranded viral DNA converts into a covalently-closed-circular chromatinized episomal structure (cccDNA). This form represents the long-lived genomic reservoir respons...
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Antibody
Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
Published: May, 2022
Abstract: BACKGROUND: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents ...
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Antibody
MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functionsin hepatocellular carcinoma by directly targeting hepatoma-derived growthfactor HDGF.
Published: May, 2022
Abstract: BACKGROUND: In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA expression is a potential tr...
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Antibody
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymaltransition
Published: May, 2022
Abstract: Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is requ...
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Antibody
Variation in PU.1 binding and chromatin looping at neutrophil enhancersinfluences autoimmune disease susceptibility
Published: May, 2022
Abstract: Neutrophils play fundamental roles in innate inflammatory response, shape adaptive immunity1, and have been identified as a potentially causal cell type underpinning genetic associations with immune system traits and diseases2,3 The majority of th...
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Antibody
Macrophage programming is regulated by a cooperative interaction betweenfatty acid binding protein 5 and peroxisome proliferator-activated receptorγ.
Published: May, 2022
Abstract: Resolution of inflammation is an active process that is tightly regulated to achieve repair and tissue homeostasis. In the absence of resolution, persistent inflammation underlies the pathogenesis of chronic lung disease such as chronic obstructiv...
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Antibody
AUXIN RESPONSE FACTOR 16 (StARF16) regulates defense gene StNPR1 upon infection with necrotrophic pathogen in potato.
Published: April, 2022
Abstract: We demonstrate a new regulatory mechanism in the jasmonic acid (JA) and salicylic acid (SA) mediated crosstalk in potato defense response, wherein, miR160 target StARF16 (a gene involved in growth and development) binds to the promoter of StNPR1 (...
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Antibody Universal Plant ChIP-seq Kit
ACTL6a coordinates axonal caliber recognition and myelination in theperipheral nerve.
Published: April, 2022
Abstract: Cells elaborate transcriptional programs in response to external signals. In the peripheral nerves, Schwann cells (SC) sort axons of given caliber and start the process of wrapping their membrane around them. We identify Actin-like protein 6a (ACT...
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Antibody
The CpG Island-Binding Protein SAMD1 Contributes to anUnfavorable Gene Signature in HepG2 Hepatocellular CarcinomaCells.
Published: April, 2022
Abstract: The unmethylated CpG island-binding protein SAMD1 is upregulated in many human cancer types, but its cancer-related role has not yet been investigated. Here, we used the hepatocellular carcinoma cell line HepG2 as a cancer model and investigated t...
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Bioruptor Antibody Microplex Library Preparation kit
MLL-AF4 and a murinized pSer-variant thereof are turning on thenucleolar stress pathway.
Published: April, 2022
Abstract: BACKGROUND: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (...
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Bioruptor Antibody
Assessment of TET1 gene expression, DNA methylation and H3K27me3level of its promoter region in eutopic endometrium of women withendometriosis and infertility.
Published: April, 2022
Abstract: Endometriosis is the cause of infertility. The eutopic endometrium of women with endometriosis showed an aberrant expression pattern of multitude genes. The role of TET1 protein in the pathogenesis of endometriosis and related infertility is not s...
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Chromatin Shearing Antibody
Local euchromatin enrichment in lamina-associated domains anticipatestheir repositioning in the adipogenic lineage.
Published: April, 2022
Abstract: BACKGROUND: Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene ex...
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Antibody Microplex Library Preparation kit
ZWC complex-mediated SPT5 phosphorylation suppresses divergentantisense RNA transcription at active gene promoters.
Published: April, 2022
Abstract: The human genome encodes large numbers of non-coding RNAs, including divergent antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by which divergent antisense transcription is regulated have not been detailed....
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Antibody
Immune disease variants modulate gene expression in regulatory CD4T cells.
Published: April, 2022
Abstract: Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are difficul...
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Antibody iDeal ChIP-seq Kit for Histones
SMYD5 is a histone H3-specific methyltransferase mediatingmono-methylation of histone H3 lysine 36 and 37.
Published: April, 2022
Abstract: Although post-translational modifications (-PTMs) of some histone H3 lysine residues are well studied, the PTMs of histone H3 lysine 37 in mammalian cells remain largely unknown. In this study, we provide evidence to show that SMYD family member 5...
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Antibody
Environmental induced transgenerational inheritance impacts systemsepigenetics in disease etiology.
Published: April, 2022
Abstract: Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pe...
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Antibody
A leukemia-protective germline variant mediates chromatin moduleformation via transcription factor nucleation.
Published: April, 2022
Abstract: Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a concep...
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Antibody
Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing.
Published: April, 2022
Abstract: Precision epigenome editing has gained significant attention as a method to modulate gene expression without altering genetic information. However, a major limiting factor has been that the gene expression changes are often transient, unlike the l...
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Antibody
Broad domains of histone marks in the highly compact macronucleargenome.
Published: April, 2022
Abstract: The unicellular ciliate contains a large vegetative macronucleus with several unusual characteristics, including an extremely high coding density and high polyploidy. As macronculear chromatin is devoid of heterochromatin, our study characterizes ...
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Antibody iDeal ChIP-seq Kit for Histones
CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells.
Published: March, 2022
Abstract: Therapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance. Targeting the transcriptional coactivators requ...
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IP-Star Antibody Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
GBS-MeDIP: A protocol for parallel identification of genetic andepigenetic variation in the same reduced fraction of genomes acrossindividuals.
Published: March, 2022
Abstract: The GBS-MeDIP protocol combines two previously described techniques, Genotype-by-Sequencing (GBS) and Methylated-DNA-Immunoprecipitation (MeDIP). Our method allows for parallel and cost-efficient interrogation of genetic and methylomic variants in...
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Antibody
H3K9 dimethylation safeguards cancer cells against activation of theinterferon pathway.
Published: March, 2022
Abstract: Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3-9 homolog 1 (SUV39H1) is r...
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Antibody
Evaluation of N6-adenine DNA-immunoprecipitation-basedgenomic profiling in eukaryotes
Published: March, 2022
Abstract: The detection of low-abundance DNA N6-methyladenine (DNA-m6A) remains challenging, limiting our understanding of this novel base in eukaryotes. To address this, we introduce an approach for systematically validating the selectivity and sensitivity...
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Antibody
Preterm birth buccal cell epigenetic biomarkers to facilitatepreventative medicine.
Published: March, 2022
Abstract: Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. The current study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mothe...
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Antibody
Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72.
Published: March, 2022
Abstract: Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can better escape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by which...
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Antibody CRISPR
Regulation of paternal 5mC oxidation and H3K9me2 asymmetry byERK1/2 in mouse zygotes.
Published: March, 2022
Abstract: BACKGROUND: Extracellular-signal-regulated kinase (ERK) direct cell fate determination during the early development. The intricate interaction between the deposition of H3K9me2, de novo 5mC, and its oxides affects the remodeling of zygotic epigene...
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Antibody
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells.
Published: February, 2022
Abstract: The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectively. However, a system enabling long-t...
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Antibody

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  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
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