Frequency and mitotic heritability of epimutations in Schistosoma mansoni Published: April, 2016 Abstract:
Schistosoma mansoni is a parasitic platyhelminth responsible for intestinal bilharzia. It has a complex life cycle, infecting a freshwater snail of the Biomphalaria genus, and then a mammalian host. Schistosoma mansoni adapts rapidly to new (allop... Read more » Tags Antibody
Sequence features accurately predict genome-wide MeCP2 binding in vivo Published: March, 2016 Abstract:
Methyl-CpG binding protein 2 (MeCP2) is critical for proper brain development and expressed at near-histone levels in neurons, but the mechanism of its genomic localization remains poorly understood. Using high-resolution MeCP2-binding data, we sh... Read more » Tags Antibody
Zbtb20 promotes astrocytogenesis during neocortical development Published: March, 2016 Abstract:
Multipotent neural precursor cells (NPCs) generate astrocytes at late stages of mammalian neocortical development. Many signalling pathways that regulate astrocytogenesis directly induce the expression of GFAP, a marker of terminally differentiate... Read more » Tags Antibody
Chemical Biology Approaches for Characterization of Epigenetic Regulators Published: February, 2016 Abstract:
Chemical biology approaches are a powerful means to functionally characterize epigenetic regulators such as histone modifying enzymes. We outline experimental protocols and best practices for the cellular characterization and use of “chemica... Read more » Tags Antibody
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence. Published: February, 2016 Abstract:
The MOZ-TIF2 translocation, that fuses MOZ (Monocytic Leukemia Zinc finger protein) histone acetyltransferase (HAT) with the nuclear co-activator TIF2, is associated the development of Acute Myeloid Leukemia. We recently showed that in t... Read more » Tags Antibody
