エピジェネティックな機構が行動と神経系の発達と機能の両方で重要な役割を果たすことが様々な研究により明らかになり、神経科学とエピジェネティクスはエキサイティングな岐路にあります。ヒストンの修飾、DNAメチル化の変化、および非コードRNAは、神経発生と脳の発達のさまざまな段階を調節する反面で、異常なエピジェネティックな調節は多くの神経障害および脳障害に関係しています。(Yao et, al. Nature Reviews Neuroscience, 2016).

神経科学者は、エピジェネティックマークと転写の変化が遺伝子発現をどのように調節して、行動や神経経路や脳構造の発達などの領域の変化に影響を与えるかを明らかにしようとしています。 エピジェネティクスが神経系機能にどのように影響するかを理解するには、複数レベルの解析を組み込んだ統合的なアプローチが必要です。その一例として転写因子、非コーディングRNA、および学習と記憶を媒介する他の分子の役割が研究により明確にされました。さらにはクロマチン修飾および非コーディングRNAは、神経発生におけるエピジェネティックなメカニズムに影響を及ぼすことが研究により明らかにされています。



  • 記憶、記憶障害、学習におけるエピジェネティクス

    Epigenetic mechanisms underlying learning and the inheritance of learned behaviors

    In this review, researchers outline epigenetic mechanisms by which gene expression is regulated in animals and humans. Using fear learning as a framework, they show how such mechanisms underlie learning and stress responsiveness. Finally, they discuss how epigenetic mechanisms might inform us about the transgenerational inheritance of behavioral traits that are being increasingly reported. Trends in Neuroscience, 2014.

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    Epigenetic regulation of memory formation and maintenance

    In the last decade, epigenetic markers like DNA methylation and post-translational modifications of histone tails have emerged as important regulators of the memory process. Their ability to regulate gene transcription dynamically in response to neuronal activation supports the consolidation of long-term memory.

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  • 統合失調症

    Epigenetic mechanisms in schizophrenia

    In this review, the authors present an overview of schizophrenia and discuss the role of nature versus nurture in its pathology, where ‘nature’ is considered to be inherited or genetic vulnerability to schizophrenia, and ‘nurture’ is proposed to exert its effects through epigenetic mechanisms. Second, they define DNA methylation and discuss the evidence for its role in schizophrenia. Third, they define posttranslational histone modifications and discuss their place in schizophrenia. This research is likely to lead to the development of epigenetic therapy, which holds the promise of alleviating cognitive deficits associated with schizophrenia. Biochimica and Biophysica Acta, 2009.

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  • 中毒障害

    Epigenetics of addiction: Epigenetic study untangles addiction and relapse in the brain

    New research uncovers an epigenetic reason why drug users who attempt to quit are prone to relapse despite negative consequences to their health and livelihood. The findings help to explain how casual drug use can produce long-lasting brain changes that increase vulnerability to relapse in individuals suffering from substance use disorders. Science Daily, September 2017.

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  • 神経発生

    Epigenetic mechanisms in neurogenesis

    Epigenetic mechanisms — including DNA and histone modifications, as well as regulation by non-coding RNAs — have pivotal roles in different stages of neurogenesis. The authors also briefly cover the emerging field of epitranscriptomics, which involves modifications of mRNAs and long non-coding RNAs.

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  • Epigenetics of depression

    Major depressive disorder (MDD) is a leading cause of disability worldwide and is associated with poor psychological, medical, and socioeconomic outcomes. This review presents the evidence supporting a role for epigenetic effects in MDD and in treatment response. Prog Mol Biol Transl Sci. 2014.

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  • レット、自閉症、パーキンソン病、ハンチントン病などその他の障害

    Parkinson’s disease

    DNA methylation in Parkinson's disease

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    Rett’s Syndrome

    Epigenetic regulation of memory by acetylation and methylation of chromatin: implications in neurological disorders, aging, and addiction

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  • Illumina index primers for D-Plex small RNA library preparation with UMI
    D-Plex 24 Single Indexes for Illumina - Set #A
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    D-Plex 24 Single Indexes for Illumina - Set #B
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    D-Plex Unique Dual Indexes for Illumina - Set A
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    D-Plex Unique Dual Indexes for Illumina - Set B
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    MagMeDIP-seq Pacakge V2
  • MagMeDIP-seq Package
    MagMeDIP-seq Package


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