Nu.Q® Discover is the first and only low-input service for absolute quantification of circulating cell-free nucleosomes and histone post-translational modifications (PTMs) in plasma liquid biopsy. This service is applicable throughout the drug development pipeline, but also from biomarker identification to clinical validation, for diagnostic and monitoring purposes in human diseases. Nu.Q® Discover offers a comprehensive portfolio covering the most studied histone PTMs, with the flexibility to personalize your project and select the assays best suited to your research goals.
Nu.Q® Discover assays provide high precision, specificity, and sensitivity, with minimal to no cross-reactivity and consistently reliable results, demonstrated by a low coefficient of variation [1].
Unique histone profiling in plasma:
Nu.Q® Discover Service, a strategic collaboration between Hologic Diagenode and Volition, expands epigenomic profiling in the chromatin space to accelerate translational research and clinical development.
*Nu.Q® is a registered trademark of VolitionRx Limited and its subsidiaries.
[1] Van den Ackerveken, Priscilla et al. High-throughput epigenetic profiling immunoassays for accelerated disease research and clinical development. Journal of Biological Chemistry, Volume 301, Issue 7, 110352 (2025).
The technology uses a fully automated magnetic bead-based sandwich immunoassay, known as known as ChemiLuminescence ImmunoAssay (ChLIA). Low-input K2 EDTA plasma (250 µL) is incubated with an acridinium ester–labeled anti-nucleosome detection antibody, then with magnetic beads coated with general anti-histone (H3.1) or specific histone PTM antibodies (capture antibody). After washing, trigger solutions are added, and luminescence is measured with a luminometer.
Applicable throughout the drug discovery and development process:
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