Whole Genome Bisulfite Sequencing (WGBS) is a single nucleotide resolution technique that allows the user to study DNA methylation sites and their role in gene regulation. The Diagenode’s Premium WGBS Kit is designed to prepare single and paired-end bisulfite converted DNA libraries for sequencing using Illumina® platforms. It has also been validated for the preparation of bisulfite converted library from ChIP’d samples in order to perform ChIP-Bis-Sequencing. For Reduced Representation Bisulfite Sequencing (RRBS) experiments use the Diagenode’s Premium RRBS Kit (Cat. No.C02030032 and C02030033).