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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptide.
Published: September, 2011
Abstract: Gene silencing by epigenetic mechanisms is frequent in prostate cancer (PCA). The link between DNA hypermethylation and histone modifications is not completely understood. We chose the GSTP1 gene which is silenced by hypermethylation to analyze th...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.
Published: September, 2011
Abstract: The Kruppel-like factor (KLF) proteins are multitasked transcriptional regulators with an expanding tumor suppressor function. KLF2 is one of the prominent members of the family because of its diminished expression in malignancies and its growth-i...
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Antibody H3K27me3 (C15410069)
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
Published: September, 2011
Abstract: Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important targets of genetic diseases. ...
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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.
Published: September, 2011
Abstract: Methylation of cytosine is a DNA modification associated with gene repression. Recently, a novel cytosine modification, 5-hydroxymethylcytosine (5-hmC) has been discovered. Here we examine 5-hmC distribution during mammalian development and in cel...
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Antibody
Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes.
Published: September, 2011
Abstract: Glucocorticoid receptor (GR) exerts anti-inflammatory action in part by antagonizing proinflammatory transcription factors such as the nuclear factor kappa-b (NFKB). Here, we assess the crosstalk of activated GR and RELA (p65, major NFKB component...
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Antibody
Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.
Published: September, 2011
Abstract: Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome architecture and epigenetic factors, but their relationship is still unknown. In this study, we isolate...
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Antibody
Improved quantitative and qualitative production of single-domain intrabodies mediated by the co-expression of Erv1p sulfhydryl oxidase.
Published: September, 2011
Abstract: Camelidae single domain antibodies (VHHs) have structural and binding features that render them suitable alternatives to conventional IgG antibodies. VHHs are usually easier to produce as recombinant proteins than other antibody fragments. However...
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Bioruptor Cell Lysis
Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae.
Published: August, 2011
Abstract: Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells. Autophagy is induced under starvation conditions and plays a cytoprotective role by degrading unwanted cytoplasmic ma...
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Antibody
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
Published: August, 2011
Abstract: The human tumour antigen PRAME (preferentially expressed antigen of melanoma) is frequently overexpressed in tumours. High PRAME levels correlate with poor clinical outcome of several cancers, but the mechanisms by which PRAME could be involved in...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.
Published: August, 2011
Abstract: Recent work has shown that RNA polymerase (Pol) II can be recruited to and transcribe distal regulatory regions. Here we analyzed transcription initiation and elongation through genome-wide localization of Pol II, general transcription factors (GT...
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Antibody
IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF.
Published: August, 2011
Abstract: BACKGROUND: IL-20 is a pleiotrophic member of the IL-10 family and plays a role in skin biology and the development of haematopoietic cells. Recently, IL-20 has been demonstrated to have potential anti-angiogenic effects in non-small cell lung can...
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Antibody H3K4me3 (C15410003)
Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction.
Published: June, 2011
Abstract: Epigenetic fields for cancerization are involved in development of human cancers, especially those associated with inflammation and multiple occurrences. However, it is still unclear when such field defects are formed and what component of inflamm...
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Antibody
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells.
Published: June, 2011
Abstract: BACKGROUND: 5-Hydroxymethylcytosine (5hmC) was recently found to be abundantly present in certain cell types, including embryonic stem cells. There is growing evidence that TET proteins, which convert 5-methylcytosine (5mC) to 5hmC, play important...
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Antibody
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.
Published: June, 2011
Abstract: We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chromatin environment present at the regula...
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Antibody
H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes.
Published: June, 2011
Abstract: The incorporation of histone variants into chromatin plays an important role for the establishment of particular chromatin states. Six human histone H3 variants are known to date, not counting CenH3 variants: H3.1, H3.2, H3.3 and the testis-specif...
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Antibody H3K4me3 (C15410003)
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.
Published: June, 2011
Abstract: AIMS: Proteins of the Polycomb repressive complex 2 (PRC2) are epigenetic gene silencers and are involved in tumour development. Their oncogenic function might be associated with their role in stem cell maintenance. The histone methyltransferase E...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Published: May, 2011
Abstract: Methylation of histone H3 lysine 4 (H3K4me), a mark associated with gene activation, is mediated by SET1 and the related mixed lineage leukemia (MLL) histone methyltransferases (HMTs) across species. Mammals contain seven H3K4 HMTs, Set1A, Set1B, ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Epigenetic profile of the euchromatic region of human Y chromosome.
Published: May, 2011
Abstract: The genome of a multi-cellular organism acquires various functional capabilities in different cell types by means of distinct chromatin modifications and packaging states. Acquired during early development, the cell type-specific epigenotype is ma...
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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit
Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.
Published: April, 2011
Abstract: The cytoplasmic tyrosine kinase Yes has previously been shown to have an important role in maintaining mouse and human embryonic stem (ES) self-renewal through an unknown pathway downstream of leukemia inhibitory factor (LIF) and one or more facto...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.
Published: April, 2011
Abstract: Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and differentiation. Despite...
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DNA shearing Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.
Published: April, 2011
Abstract: Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribu...
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Antibody
Recombineering, transfection, Western, IP and ChIP methods for protein tagging via gene targeting or BAC transgenesis.
Published: April, 2011
Abstract: Protein tagging offers many advantages for proteomic and regulomic research. Ideally, protein tagging is equivalent to having a high affinity antibody for every chosen protein. However, these advantages are compromised if the tagged protein is ove...
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Bioruptor Chromatin Shearing ChIP-qPCR Cell Lysis Western Blot Antibody
Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer
Published: March, 2011
Abstract: Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, overexpression of the insulin...
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Antibody H3K4me3 (C15410003)
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.
Published: March, 2011
Abstract: The epigenomes of early mammalian embryos are extensively reprogrammed to acquire a totipotent developmental potential. A major initial event in this reprogramming is the active loss/demethylation of 5-methylcytosine (5mC) in the zygote. Here, we ...
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Antibody
Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer.
Published: March, 2011
Abstract: Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tu...
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Antibody 5mC (C15200081)
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.
Published: February, 2011
Abstract: Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with guanine, it was proposed to act against the mutability of 5-methylcytosine ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.
Published: February, 2011
Abstract: The H3K9me3 histone modification is often found at promoter regions, where it functions to repress transcription. However, we have previously shown that 3' exons of zinc finger genes (ZNFs) are marked by high levels of H3K9me3. We have now further...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Comprehensive analysis of DNA-methylation in mammalian tissues using MeDIP-chip.
Published: February, 2011
Abstract: Genome-wide mapping of epigenetic changes is essential for understanding the mechanisms involved in gene regulation during cell differentiation and embryonic development. DNA-methylation is one of these key epigenetic marks that is directly linked...
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DNA shearing Bioruptor Antibody
Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.
Published: February, 2011
Abstract: AIMS: Human thoracic aortic aneurysms (TAAs) are characterized by extracellular matrix breakdown associated with progressive smooth muscle cell (SMC) rarefaction. These features are present in all types of TAA: monogenic forms [mainly Marfan syndr...
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Antibody Histone ChIP kit
Recombineering BAC transgenes for protein tagging.
Published: February, 2011
Abstract: Protein tagging offers many advantages for proteomic and regulomic research, particularly due to the use of generic and highly sensitive methods that can be applied with reasonable throughput. Ideally, protein tagging is equivalent to having a hig...
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Bioruptor Cell Lysis Western Blot

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