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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
Genome-wide analysis of day/night DNA methylation differences in Populus nigra.
Published: January, 2018
Abstract: DNA methylation is an important mechanism of epigenetic modification. Methylation changes during stress responses and developmental processes have been well studied; however, their role in plant adaptation to the day/night cycle is poorly understo...
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MagMeDIP kit Antibody
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Published: January, 2018
Abstract: Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly e...
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MagMeDIP kit Antibody
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes
Published: January, 2018
Abstract: Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active promoters yet paradoxically occurs at untranscribed domains. Research to delineate the mechanisms of targeting H3K4 methyltransferases is ongoing. The oocyt...
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Antibody Microplex Library Preparation kit
RNA-Based dCas9–VP64 System Improves the Viability of Cryopreserved Mammalian Cells
Published: January, 2018
Abstract: Regenerative therapies require availability of an abundant healthy cell source which can be achieved by e±cient cryopreservation techniques. Here, we established a novel approach for improved cell cryopreservation using an mRNA-based dCas9-...
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Antibody CRISPR
Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufiency.
Published: January, 2018
Abstract: Two of the most prevalent ovarian diseases affecting women's fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can ...
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Antibody
Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification.
Published: January, 2018
Abstract: Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular changes associated with the tumor-suppressive action of Metformin we found that the onco...
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Antibody
Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model.
Published: January, 2018
Abstract: Background: Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia (BPD). Methods: Here, we analyzed short- and long-term effects of neonatal hyperoxia on NOS3 and STAT3 exp...
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Antibody
Analysis of DNA methylome and transcriptome profiling following Gibberellin A3 (GA3) foliar application in Nicotiana tabacum L.
Published: January, 2018
Abstract: The present work investigated a comprehensive genome-wide landscape of DNA methylome and its relationship with transcriptome upon gibberellin A3 (GA3) foliar application under practical field conditions in solanaceae model, Nicotiana tabacum L. Me...
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MagMeDIP kit Antibody
BRACHYURY directs histone acetylation to target loci during mesoderm development.
Published: January, 2018
Abstract: T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (...
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Antibody
(Po)STAC (Polycistronic SunTAg modified CRISPR) enables live-cell and fixed-cell super-resolution imaging of multiple genes
Published: December, 2017
Abstract: CRISPR/dCas9-based labeling has allowed direct visualization of genomic regions in living cells. However, poor labeling efficiency and signal-to-background ratio have limited its application to visualize genome organization using super-resolution ...
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Antibody
Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation
Published: December, 2017
Abstract: Cockayne syndrome (CS) is caused by mutations in CSA and CSB. The CSA and CSB proteins have been linked to both promoting transcription-coupled repair and restoring transcription following DNA damage. We show that UV stress arrests transcription o...
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Antibody
The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells
Published: December, 2017
Abstract: Therapeutic intervention is an important need in ameliorating the severe consequences of Rett Syndrome (RTT), a neurological disorder caused by mutations in the X-linked gene methyl-CpG-binding protein-2 (MeCP2). Following previously observed morp...
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Antibody
Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer
Published: December, 2017
Abstract: Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. We ...
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Antibody
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer
Published: December, 2017
Abstract: Breast cancer is the most common cancer in women, and the leading cause of cancer death in women worldwide. SIRT1 (silent mating type information regulation 2 homolog) 1 is a class-III histone deacetylase involved in apoptosis regulation, DNA repa...
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Antibody
EZH2 Histone Methyltransferase and JMJD3 Histone Demethylase Implications in Prostate Cancer
Published: December, 2017
Abstract:
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Antibody
Optimization of CRISPR/Cas9 genome editing for loss-of-function in the early chick embryo
Published: December, 2017
Abstract: The advent of CRISPR/Cas9 has made genome editing possible in virtually any organism, including those not previously amenable to genetic manipulations. Here, we present an optimization of CRISPR/Cas9 for application to early avian embryos with imp...
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Antibody
Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
Published: November, 2017
Abstract: At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that associate to form nuclear compartments. Here, we combine high-content super-resolution microscop...
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Antibody
The histone code reader Spin1 controls skeletal muscle development
Published: November, 2017
Abstract: While several studies correlated increased expression of the histone code reader Spin1 with tumor formation or growth, little is known about physiological functions of the protein. We generated Spin1M5 mice with ablation of Spin1 in myoblast precu...
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Antibody IP-Star Compact
DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes
Published: November, 2017
Abstract: Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed lar...
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Antibody
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
Published: November, 2017
Abstract: The set of events that convert adherent epithelial cells into migratory cells are collectively known as epithelial-mesenchymal transition (EMT). EMT is involved during development, for example, in triggering neural crest migration, and in pathogen...
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Antibody
In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells
Published: November, 2017
Abstract: Summary State of the art techniques have been developed to isolate and analyze cells from various tissues, aiming to capture their in vivo state. However, the majority of cell isolation protocols involve lengthy mechanical and enzymatic ...
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Antibody Premium RRBS Kit
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
Published: November, 2017
Abstract: To elucidate the molecular basis of BMP4-induced differentiation of human pluripotent stem cells (PSCs) toward progeny with trophectoderm characteristics, we produced transcriptome, epigenome H3K4me3, H3K27me3, and CpG methylation maps of trophobl...
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Antibody
5-Methylcytosine RNA Methylation in Arabidopsis Thaliana
Published: November, 2017
Abstract: 5-Methylcytosine (m5C) is a well-characterized DNA modification, and is also predominantly reported in abundant non-coding RNAs in both prokaryotes and eukaryotes. However, the distribution and biological functions of m5C in plant mRNAs remain lar...
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Antibody
Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
Published: October, 2017
Abstract: The nuclease-deactivated variant of CRISPR-Cas9 proteins (dCas9) fused to heterologous transactivation domains can act as a potent guide RNA sequence-directed inducer or repressor of gene expression in mammalian cells. In such a system the long-te...
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Antibody
Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation
Published: October, 2017
Abstract: The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later li...
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Antibody
The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting
Published: October, 2017
Abstract: Genomic imprinting is an allelic gene expression phenomenon primarily controlled by allele-specific DNA methylation at the imprinting control region (ICR), but the underlying mechanism remains largely unclear. N-α-acetyltransferase 10 protei...
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Antibody
The mixed lineage leukemia 4 (MLL4) methyltransferase complex is involved in transforming growth factor beta (TGF-β)-activated gene transcription.
Published: October, 2017
Abstract: Sma and Mad related (SMAD)-mediated Transforming Growth Factor β (TGF-β) and Bone Morphogenetic Protein (BMP) signaling is required for various cellular processes. The activated heterotrimeric SMAD protein complexes associate with nuclea...
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Antibody
Rapid Communication: The correlation between histone modifications and expression of key genes involved in accumulation of adipose tissue in the pig.
Published: October, 2017
Abstract: Histone modification is a well-known epigenetic mechanism involved in regulation of gene expression; however, it has been poorly studied in adipose tissues of the pig. Understanding the molecular background of adipose tissue development and functi...
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Antibody LowCell ChIP kit
TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells
Published: September, 2017
Abstract: The plasticity of myeloid cells is illustrated by a diversity of functions including their role as effectors of innate immunity as macrophages (MACs) and bone remodelling as osteoclasts (OCs). TET2, a methylcytosine dioxygenase highly expressed in...
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Antibody LowCell ChIP kit
Predicting stimulation-dependent enhancer-promoter interactions from ChIP-Seq time course data
Published: September, 2017
Abstract: We have developed a machine learning approach to predict stimulation-dependent enhancer-promoter interactions using evidence from changes in genomic protein occupancy over time. The occupancy of estrogen receptor alpha (ERα), RNA polymerase ...
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Antibody

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