Diagenode
| United States | My cart | 登录 / 注册 搜索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.
Published: January, 2019
Abstract: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-functio...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones iDeal Library Preparation Kit
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Published: January, 2019
Abstract: BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chrom...
Read more »
Tags
Antibody
Global distribution of DNA hydroxymethylation and DNA methylation in chronic lymphocytic leukemia.
Published: January, 2019
Abstract: BACKGROUND: Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More recently, an oxidized form of 5-mC, 5-hydroxymethylcytosine (5-hmC) has gained lot...
Read more »
Tags
MagMeDIP kit Antibody
Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements.
Published: January, 2019
Abstract: Editing the β-globin locus in hematopoietic stem cells is an alternative therapeutic approach for gene therapy of β-thalassemia and sickle cell disease. Using the CRISPR/Cas9 system, we genetically modified human hematopoietic stem and p...
Read more »
Tags
Antibody
Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon.
Published: January, 2019
Abstract: Ionizing radiation is a recognized genotoxic agent, however, little is known about the role of the functional form of DNA in these processes. Post translational modifications on histone proteins control the organization of chromatin and hence cont...
Read more »
Tags
Antibody
Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha.
Published: January, 2019
Abstract: Estrogen Receptor alpha (ERα) plays a major role in most breast cancers, and it is the target of endocrine therapies used in the clinic as standard of care for women with breast cancer expressing this receptor. The two methods ChIP-seq (chro...
Read more »
Tags
Antibody
Transcriptome-Wide Mapping 5-Methylcytosine by mC RNA Immunoprecipitation Followed by Deep Sequencing in Plant.
Published: January, 2019
Abstract: Transcriptome-wide mapping RNA modification is crucial to understand the distribution and function of RNA modifications. Here, we describe a protocol to transcriptome-wide mapping 5-methylcytosine (mC) in plant, by a RNA immunoprecipitation follow...
Read more »
Tags
Antibody
Sensitivity of pituitary gonadotropes to hyperglycemia leads to epigenetic aberrations and reduced follicle-stimulating hormone levels.
Published: December, 2018
Abstract: The connection between metabolism and reproductive function is well recognized, and we hypothesized that the pituitary gonadotropes, which produce luteinizing hormone and follicle-stimulating hormone (FSH), mediate some of the effects directly via...
Read more »
Tags
Antibody
DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.
Published: December, 2018
Abstract: Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advances in pancreatic cancer research uncovered various molecular subtypes with tumors expressing a squamo...
Read more »
Tags
Antibody Microplex Library Preparation kit
Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape.
Published: December, 2018
Abstract: Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. However, ...
Read more »
Tags
Antibody
Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts.
Published: December, 2018
Abstract: Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands. Yet, mechanisms underlying gametocytes interactions with th...
Read more »
Tags
Antibody
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer.
Published: December, 2018
Abstract: BACKGROUND: The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown. METHOD: We checked the ex...
Read more »
Tags
Antibody
SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.
Published: December, 2018
Abstract: Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 (H2AQ104me). The mechanisms that regulate FBL activity are unexplored. Here, we show that FBL is ace...
Read more »
Tags
Antibody
Enhancers in the Peril lincRNA locus regulate distant but not local genes.
Published: December, 2018
Abstract: BACKGROUND: Recently, it has become clear that some promoters function as long-range regulators of gene expression. However, direct and quantitative assessment of enhancer activity at long intergenic noncoding RNA (lincRNA) or mRNA gene bodies has...
Read more »
Tags
Antibody
Can Mitochondrial DNA be CRISPRized: Pro and Contra.
Published: December, 2018
Abstract: Mitochondria represent a chimera of macromolecules encoded either in the organellar genome, mtDNA, or in the nuclear one. If the pathway of protein targeting to different sub-compartments of mitochondria was relatively well studied, import of smal...
Read more »
Tags
Antibody CRISPR Cas9 (C15200203)
Genomic integrity of ground-state pluripotency.
Published: December, 2018
Abstract: Pluripotent cells appear to be in a transient state during early development. These cells have the capability to transition into embryonic stem cells (ESCs). It has been reported that mouse pluripotent cells cultivated in chemically defined media ...
Read more »
Tags
Antibody
Human retinoic acid-regulated CD161 regulatory T cells support wound repair in intestinal mucosa.
Published: December, 2018
Abstract: Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161 regulatory T (T) cells as a distinct, highly suppressive population of T cells that me...
Read more »
Tags
Antibody
Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure.
Published: November, 2018
Abstract: Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentally induced germline changes can promote the epigenetic transgenerational inheritance of disease and p...
Read more »
Tags
Antibody
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression.
Published: November, 2018
Abstract: Hypoxia-inducible factors (HIFs) play a key role in the adaptation to low oxygen by interacting with hypoxia response elements (HREs) in the genome. Cellular levels of the HIF-2α transcription factor subunit influence the histopathology and ...
Read more »
Tags
Antibody
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Published: November, 2018
Abstract: Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse model, we demonstrate that local macrophage activation through dectin-1 and toll-like recepto...
Read more »
Tags
Antibody
Sensitive tumour detection and classification using plasma cell-free DNA methylomes.
Published: November, 2018
Abstract: The use of liquid biopsies for cancer detection and management is rapidly gaining prominence. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA, but the sensitivity of these method...
Read more »
Tags
MagMeDIP kit Antibody IPure kit
Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.
Published: November, 2018
Abstract: The pluripotent ground state is defined as a basal state free of epigenetic restrictions, which influence lineage specification. While naive embryonic stem cells (ESCs) can be maintained in a hypomethylated state with open chromatin when grown usi...
Read more »
Tags
Antibody
RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation.
Published: November, 2018
Abstract: BACKGROUND: The cellular response to ionizing radiation involves activation of p53-dependent pathways and activation of the atypical NF-κB pathway. The crosstalk between these two transcriptional networks include (co)regulation of common gen...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Transcription Factors
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Published: November, 2018
Abstract: Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs). We observed successive waves of hydroxymethylation at enhancers, ...
Read more »
Tags
Antibody
Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression.
Published: November, 2018
Abstract: SOX transcription factors have important roles during astrocyte and oligodendrocyte development, but how glial genes are specified and activated in a sub-lineage-specific fashion remains unknown. Here, we define glial-specific gene expression in t...
Read more »
Tags
Antibody
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Published: November, 2018
Abstract: Epigenetic regulators have been shown to influence breast cancer progression. However, the detailed mechanism by which TET2 plays the suppressive role in tumorigenesis remains not completely understood. We employed RT-qPCR and westernblot to exami...
Read more »
Tags
Antibody
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.
Published: October, 2018
Abstract: Perturbed epigenomic programs play key roles in tumorigenesis, and chromatin modulators are candidate therapeutic targets in various human cancer types. To define singular and shared dependencies on DNA and histone modifiers and transcription fact...
Read more »
Tags
Antibody
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States
Published: October, 2018
Abstract: Understanding general principles that safeguard cellular identity should reveal critical insights into common mechanisms underlying specification of varied cell types. Here, we show that SUMO modification acts to stabilize cell fate in a variety o...
Read more »
Tags
Antibody Microplex Library Preparation kit
Centromeres License the Mitotic Condensation of Yeast Chromosome Arms.
Published: October, 2018
Abstract: During mitosis, chromatin condensation shapes chromosomes as separate, rigid, and compact sister chromatids to facilitate their segregation. Here, we show that, unlike wild-type yeast chromosomes, non-chromosomal DNA circles and chromosomes lackin...
Read more »
Tags
Antibody
Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development.
Published: October, 2018
Abstract: BACKGROUND: Reactive oxygen species (ROS)-induced oxidative stress is well known to play a major role in male infertility. Sperm are sensitive to ROS damaging effects because as male germ cells form mature sperm they progressively lose the ability...
Read more »
Tags
Antibody

活动

  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
 查看所有活动

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy