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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Single-cell multi-omics, spatial transcriptomics and systematic perturbation decode circuitry of neural crest fate decisions
Published: September, 2024
Abstract: Cranial neural crest (NC) cells, which can migrate, adopt multiple fates, and form most of the craniofacial skeleton, are an excellent model for studying cell fate decisions. Using time-resolved single-cell multi-omics, spatial transcriptomics, an...
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Antibody True MicroChIP kit
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk
Published: September, 2024
Abstract: Genome-wide association studies of colorectal cancer (CRC) have identified 170 autosomal risk loci. However, for most of these, the functional variants and their target genes are unknown. Here, we perform statistical fine-mapping incorporating tis...
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Antibody
Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+ cells
Published: September, 2024
Abstract: Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation. The role of BvCR in post-...
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Antibody
RNA sequestration in P-bodies sustains myeloid leukaemia
Published: August, 2024
Abstract: Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide...
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Antibody CUT&Tag
Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation
Published: August, 2024
Abstract: The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived cell types. We have recently developed hiPSC with s...
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Antibody CRISPR
LL37/self-DNA complexes mediate monocyte reprogramming
Published: August, 2024
Abstract: LL37 alone and in complex with self-DNA triggers inflammatory responses in myeloid cells and plays a crucial role in the development of systemic autoimmune diseases, like psoriasis and systemic lupus erythematosus. We demonstrated that LL37/self-D...
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Antibody
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
Published: July, 2024
Abstract: The reduced ability of the central nervous system to regenerate with increasing age limits functional recovery following demyelinating injury. Previous work has shown that myelin debris can overwhelm the metabolic capacity of microglia, thereby im...
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Antibody iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment
Published: July, 2024
Abstract: Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of healthy ...
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Antibody Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression
Published: July, 2024
Abstract: Low response rate, treatment relapse, and resistance remain key challenges for cancer treatment with immune checkpoint blockade (ICB). Here we report that loss of specific tumor suppressors (TS) induces an inflammatory response and promotes an imm...
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Antibody CRISPR
Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia
Published: July, 2024
Abstract: Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phenotype....
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Antibody Microplex Library Preparation kit
The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance
Published: June, 2024
Abstract: RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We established a landscape analysis of RNA-chromatin interactions in human acute myeloid leukemia (A...
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Bioruptor Antibody iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones
Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
Published: June, 2024
Abstract: Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding of its ...
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MagMeDIP kit Antibody IPure kit
KRAS promotes GLI2-dependent transcription during pancreatic carcinogenesis
Published: June, 2024
Abstract: Aberrant activation of GLI transcription factors has been implicated in the pathogenesis of different tumor types including pancreatic ductal adenocarcinoma (PDAC). However, the mechanistic link with established drivers of this disease remains in ...
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Antibody
Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Published: June, 2024
Abstract: Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity ha...
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Bioruptor Antibody
Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
Published: June, 2024
Abstract: While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to their str...
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Antibody
Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
Published: June, 2024
Abstract: While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to their str...
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Antibody
Brassica rapa CURLY LEAF is a major H3K27 methyltransferase regulating flowering time
Published: June, 2024
Abstract: Main conclusion In Brassica rapa, the epigenetic modifier BraA.CLF orchestrates flowering by modulating H3K27me3 levels at the floral integrator genes FT, SOC1, and SEP3, thereby influencing their expression. Abstract CURLY ...
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Antibody
Chromatin profiling reveals TFAP4 as a critical transcriptional regulator of bovine satellite cell differentiation
Published: March, 2024
Abstract: Background Satellite cells are myogenic precursor cells in adult skeletal muscle and play a crucial role in skeletal muscle regeneration, maintenance, and growth. Like embryonic myoblasts, satellite cells have the ability to proliferate, differen...
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Antibody iDeal ChIP-seq Kit for Histones
SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS
Published: March, 2024
Abstract: This study explores a regulatory role of oncoprotein survivin on the bivalent regions of chromatin (BvCR) characterized by concomitant deposition of trimethylated lysine of histone H3 at position 4 (H3K4me3) and 27 (H3K27me3). Intersect between B...
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Antibody
Revisiting chromatin packaging in mouse sperm
Published: December, 2023
Abstract:
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Antibody Tagmentase
In vitro production of cat-restricted Toxoplasma pre-sexual stages
Published: December, 2023
Abstract: Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during i...
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Antibody IPure kit iDeal ChIP-seq Kit for Transcription Factors ATAC-seq
SUMO protease FUG1, histone reader AL3 and the PRC1 Complex areintegral to repeat-expansion induced epigenetic silencing in Arabidopsisthaliana
Published: December, 2023
Abstract: Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich’s ataxia in humans1. The molecular mechanisms underlying repeat expansion-...
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Antibody
An enriched maternal environment and stereotypies of sows differentiallyaffect the neuro-epigenome of brain regions related to emotionality intheir piglets.
Published: December, 2023
Abstract: Epigenetic mechanisms are important modulators of neurodevelopmental outcomes in the offspring of animals challenged during pregnancy. Pregnant sows living in a confined environment are challenged with stress and lack of stimulation which may resu...
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Antibody
KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties
Published: November, 2023
Abstract: Mature lymphoid stromal cells (LSCs) are key organizers of immune responses within secondary lymphoid organs. Similarly, inflammation-driven tertiary lymphoid structures depend on immunofibroblasts producing lymphoid cytokines and chemokines. Rece...
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Antibody
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
Published: November, 2023
Abstract: CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In myeloid leukemia cells, it promotes rapid eviction of EP300/CBP from an enha...
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Antibody Microplex Library Preparation kit Tagmentase
H3K9 methylation patterns during somatic embryogenic competenceexpression in tamarillo (Solanum betaceum Cav.)
Published: November, 2023
Abstract: The capacity to regenerate is intrinsic to plants and is the basis of natural asexual propagation and artificial cloning. Despite there are different ways of plant regeneration, they all require a change in cell fate and pluripotency reacquisition...
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Antibody
ThPOK is a critical multifaceted regulator of myeloid lineagedevelopment.
Published: August, 2023
Abstract: The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and critical role of ThPOK as a multifaceted regulator of myeloid lineage co...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Zfp296 knockout enhances chromatin accessibility and induces a uniquestate of pluripotency in embryonic stem cells.
Published: July, 2023
Abstract: The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296-knockout (KO) ESCs grew as flat colonies, which were reverted to rounded coloni...
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Antibody Tagmentase
Carnobacterium maltaromaticum boosts intestinal vitamin D production tosuppress colorectal cancer in female mice.
Published: July, 2023
Abstract: Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific m...
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Antibody
Enhanced frequency of transcription pre-initiation complexes assemblyafter exposure to UV irradiation results in increased repair activity andreduced probabilities for mutagenesis.
Published: July, 2023
Abstract: In addition to being essential for gene expression, transcription is crucial for the maintenance of genome integrity. Here, we undertook a systematic approach, to monitor the assembly kinetics of the pre-initiating RNA Polymerase (Pol) II at promo...
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Antibody

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