Diagenode
| United States | My cart | 登录 / 注册 搜索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
The transcription factor scleraxis differentially regulates gene expressionin tenocytes isolated at different developmental stages.
Published: August, 2020
Abstract: The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that...
Read more »
Tags
Antibody iDeal ChIP-qPCR
Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even ThroughFibroblast Dedifferentiation
Published: August, 2020
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myofibroblasts plays a key role in fibrotic tissue remodeling. The dedifferentiation of myofibroblasts ...
Read more »
Tags
Antibody
PR-DUB maintains expression of critical genes through FOXK1/2 andASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1deubiquitination.
Published: August, 2020
Abstract: Polycomb group proteins are important for maintaining gene expression patterns and cell identity in metazoans. The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A...
Read more »
Tags
Antibody
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal CellsRegulating Genes Associated With Kidney Dysfunction.
Published: August, 2020
Abstract: Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of end-stage renal failure. Epigenetics has been associated with metabolic memory, in which prior periods of hyperglycemia enhance the future risk of developin...
Read more »
Tags
Antibody
Exploring the virulence gene interactome with CRISPR/dCas9 in the humanmalaria parasite.
Published: August, 2020
Abstract: Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR-based proteomics approach to identify novel fa...
Read more »
Tags
Bioruptor Antibody Microplex Library Preparation kit
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2 and U2AF1 Genes in Prostate Cancer Cell Lines.
Published: August, 2020
Abstract: Abstract not availabale
Read more »
Tags
Antibody
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development
Published: July, 2020
Abstract: The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC-sequencing and Ch...
Read more »
Tags
ChIP-seq Antibody
OxLDL-mediated immunologic memory in endothelial cells.
Published: July, 2020
Abstract: Trained innate immunity describes the metabolic reprogramming and long-term proinflammatory activation of innate immune cells in response to different pathogen or damage associated molecular patterns, such as oxidized low-density lipoprotein (oxLD...
Read more »
Tags
Antibody
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Published: July, 2020
Abstract: Psoriasis is a frequent inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cells. Here, we identified a novel pro-inflammatory signaling pathway driven by the cyclin-dependent ki...
Read more »
Tags
Antibody
The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.
Published: July, 2020
Abstract: Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that Integrator subunit 11 (INTS11), the catalytic su...
Read more »
Tags
Antibody ChIP Cross-link Gold
Prostate cancer reactivates developmental epigenomic programs during metastatic progression.
Published: July, 2020
Abstract: Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription factor. We generated 268 epigenomic datasets spanning two state transitions-from ...
Read more »
Tags
Antibody
MeCP2 regulates gene expression through recognition of H3K27me3.
Published: July, 2020
Abstract: MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 sug...
Read more »
Tags
Antibody
Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation
Published: July, 2020
Abstract: Ionizing radiation is known to induce oxidative stress and DNA damage as well as epigenetic effects in aquatic organisms. Epigenetic changes can be part of the adaptive responses to protect organisms from radiation-induced damage, or act as driver...
Read more »
Tags
Antibody
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.
Published: July, 2020
Abstract: Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann ce...
Read more »
Tags
Antibody Microplex Library Preparation kit
Premature termination codons in the gene cause reduced local mRNA synthesis.
Published: July, 2020
Abstract: Duchenne muscular dystrophy (DMD) is caused by mutations in the gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced DMD transcript levels in DMD patient and animal model muscles w...
Read more »
Tags
Antibody
Identification of Novel Molecular Markers of Human Th17 Cells.
Published: July, 2020
Abstract: Th17 cells are important players in host defense against pathogens such as , , and . Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted, is the underlying pathogenic mechanism of certain au...
Read more »
Tags
Antibody
FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues.
Published: June, 2020
Abstract: Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in formalin-fixed, paraffin-embedded (FFPE) tissues. We previously developed a modified ChIP-seq proto...
Read more »
Tags
Antibody
The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications.
Published: June, 2020
Abstract: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with pote...
Read more »
Tags
Antibody
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.
Published: June, 2020
Abstract: Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show...
Read more »
Tags
MagMeDIP kit Antibody
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Published: June, 2020
Abstract: Improving early cancer detection has the potential to substantially reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) is a highly sensitive assay capable of detecting early-s...
Read more »
Tags
MagMeDIP kit Antibody IPure kit
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
Published: June, 2020
Abstract: How the epigenetic landscape is established in development is still being elucidated. Here, we uncover developmental pluripotency associated 2 and 4 (DPPA2/4) as epigenetic priming factors that establish a permissive epigenetic landscape at a subs...
Read more »
Tags
Antibody Microplex Library Preparation kit
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.
Published: June, 2020
Abstract: A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on-target mutations or parallel pathway alterati...
Read more »
Tags
Antibody Microplex Library Preparation kit
Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia.
Published: June, 2020
Abstract: Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease, with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensiv...
Read more »
Tags
Antibody
DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain.
Published: June, 2020
Abstract: Methylation of cytosine residues in DNA influences chromatin structure and gene transcription, and its regulation is crucial for brain development. There is mounting evidence that DNA methylation can be modulated by hormone signaling. We analyzed ...
Read more »
Tags
Antibody MethylCap
An optimised Chromatin Immunoprecipitation (ChIP) method for starchy leaves of Nicotiana benthamiana to study histone modifications of an allotetraploid plant
Published: June, 2020
Abstract: All flowering plants have evolved through multiple rounds of polyploidy throughout the evolutionary process. Intergenomic interactions between subgenomes in polyploid plants are predicted to induce chromatin modifications such as histone modificat...
Read more »
Tags
Antibody
Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer
Published: June, 2020
Abstract: RING1B, a core Polycomb repressive complex 1 subunit, is a histone H2A ubiquitin ligase essential for development. RING1B is overexpressed in patients with luminal breast cancer (BC) and recruited to actively transcribed genes and enhancers co-occ...
Read more »
Tags
Antibody
Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy.
Published: June, 2020
Abstract: BACKGROUND: Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and promoters. The binding of transcriptional regulators enables the interaction betwee...
Read more »
Tags
Antibody
A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.
Published: June, 2020
Abstract: Heterochromatic domains containing histone H3 lysine 9 methylation (H3K9me) can be epigenetically inherited independently of underlying DNA sequence. To gain insight into the mechanisms that mediate epigenetic inheritance, we used a inducible hete...
Read more »
Tags
Antibody
Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation.
Published: June, 2020
Abstract: Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition into the transcriptionally active state. However, the mechanisms underlying euchromatin establishment during early embryogenesis remain poorly under...
Read more »
Tags
Antibody
The hypomethylation of imprinted genes in IVF/ICSI placenta samplesis associated with concomitant changes in histone modifications.
Published: June, 2020
Abstract: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with pote...
Read more »
Tags
Antibody

活动

 查看所有活动

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy