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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
p53 directly represses human LINE1 transposons.
Published: October, 2020
Abstract: p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline tissues of flies and fish but whether this activity is conserved in somatic human cells i...
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Antibody
Formation of the CenH3-Deficient Holocentromere in Lepidoptera AvoidsActive Chromatin.
Published: October, 2020
Abstract: Despite the essentiality for faithful chromosome segregation, centromere architectures are diverse among eukaryotes and embody two main configurations: mono- and holocentromeres, referring, respectively, to localized or unrestricted distribution o...
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Antibody iDeal ChIP-seq Kit for Histones Beads
Age-associated cryptic transcription in mammalian stem cells is linked topermissive chromatin at cryptic promoters
Published: October, 2020
Abstract: Suppressing spurious cryptic transcription by a repressive intragenic chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation is critical for maintaining self-renewal capacity in mouse embryonic stem cells. I...
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Antibody Microplex Library Preparation kit True MicroChIP kit
UTX/KDM6A suppresses AP-1 and a gliogenesis program during neuraldifferentiation of human pluripotent stem cells.
Published: September, 2020
Abstract: BACKGROUND: UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene regulation remain unclear. R...
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Antibody
Between-Generation Phenotypic and Epigenetic Stability in a Clonal Snail.
Published: September, 2020
Abstract: Epigenetic variation might play an important role in generating adaptive phenotypes by underpinning within-generation developmental plasticity, persistent parental effects of the environment (e.g., transgenerational plasticity), or heritable epige...
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Antibody
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptiveredistribution of BAF complexes
Published: September, 2020
Abstract: SWI/SNF chromatin remodelers play critical roles in development and cancer. The causal links between SWI/SNF complex disassembly and carcinogenesis are obscured by redundancy between paralogous components. Canonical BAF (cBAF)-specific paralogs AR...
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Antibody
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal rootganglia organoid-derived sensory neurons.
Published: August, 2020
Abstract: Friedreich's ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac disorder which occurs when transcription of the FXN gene is silenced due to an excessive expansion of GAA repeats into its first intron. Herein, we generate dorsal ...
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MagMeDIP kit Antibody
Combined treatment with CBP and BET inhibitors reverses inadvertentactivation of detrimental super enhancer programs in DIPG cells.
Published: August, 2020
Abstract: Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K...
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Bioruptor Antibody Microplex Library Preparation kit
A gene therapy for inherited blindness using dCas9-VPR–mediatedtranscriptional activation
Published: August, 2020
Abstract: Catalytically inactive dCas9 fused to transcriptional activators (dCas9-VPR) enables activation of silent genes. Many disease genes have counterparts, which serve similar functions but are expressed in distinct cell types. One attractive option to...
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Antibody CRISPR
Differential Expression of Members of SOX Family of Transcription Factorsin Failing Human Hearts
Published: August, 2020
Abstract: Background: The Sry-related high-mobility-group box (SOX) gene family, with 20 known transcription factors in humans, plays essential roles during development and in many disease processes. Several SOX proteins, e.g., SOX4, SOX11, and SOX9, are re...
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Antibody
The transcription factor scleraxis differentially regulates gene expressionin tenocytes isolated at different developmental stages.
Published: August, 2020
Abstract: The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that...
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Antibody iDeal ChIP-qPCR
Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even ThroughFibroblast Dedifferentiation
Published: August, 2020
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myofibroblasts plays a key role in fibrotic tissue remodeling. The dedifferentiation of myofibroblasts ...
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Antibody
PR-DUB maintains expression of critical genes through FOXK1/2 andASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1deubiquitination.
Published: August, 2020
Abstract: Polycomb group proteins are important for maintaining gene expression patterns and cell identity in metazoans. The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A...
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Antibody
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal CellsRegulating Genes Associated With Kidney Dysfunction.
Published: August, 2020
Abstract: Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of end-stage renal failure. Epigenetics has been associated with metabolic memory, in which prior periods of hyperglycemia enhance the future risk of developin...
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Antibody
Exploring the virulence gene interactome with CRISPR/dCas9 in the humanmalaria parasite.
Published: August, 2020
Abstract: Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR-based proteomics approach to identify novel fa...
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Bioruptor Antibody Microplex Library Preparation kit
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2 and U2AF1 Genes in Prostate Cancer Cell Lines.
Published: August, 2020
Abstract: Abstract not availabale
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Antibody
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development
Published: July, 2020
Abstract: The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC-sequencing and Ch...
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ChIP-seq Antibody
OxLDL-mediated immunologic memory in endothelial cells.
Published: July, 2020
Abstract: Trained innate immunity describes the metabolic reprogramming and long-term proinflammatory activation of innate immune cells in response to different pathogen or damage associated molecular patterns, such as oxidized low-density lipoprotein (oxLD...
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Antibody
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Published: July, 2020
Abstract: Psoriasis is a frequent inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cells. Here, we identified a novel pro-inflammatory signaling pathway driven by the cyclin-dependent ki...
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Antibody
The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.
Published: July, 2020
Abstract: Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that Integrator subunit 11 (INTS11), the catalytic su...
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Antibody ChIP Cross-link Gold
Prostate cancer reactivates developmental epigenomic programs during metastatic progression.
Published: July, 2020
Abstract: Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription factor. We generated 268 epigenomic datasets spanning two state transitions-from ...
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Antibody
MeCP2 regulates gene expression through recognition of H3K27me3.
Published: July, 2020
Abstract: MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 sug...
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Antibody
Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation
Published: July, 2020
Abstract: Ionizing radiation is known to induce oxidative stress and DNA damage as well as epigenetic effects in aquatic organisms. Epigenetic changes can be part of the adaptive responses to protect organisms from radiation-induced damage, or act as driver...
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Antibody
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.
Published: July, 2020
Abstract: Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann ce...
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Antibody Microplex Library Preparation kit
Premature termination codons in the gene cause reduced local mRNA synthesis.
Published: July, 2020
Abstract: Duchenne muscular dystrophy (DMD) is caused by mutations in the gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced DMD transcript levels in DMD patient and animal model muscles w...
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Antibody
Identification of Novel Molecular Markers of Human Th17 Cells.
Published: July, 2020
Abstract: Th17 cells are important players in host defense against pathogens such as , , and . Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted, is the underlying pathogenic mechanism of certain au...
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Antibody
FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues.
Published: June, 2020
Abstract: Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in formalin-fixed, paraffin-embedded (FFPE) tissues. We previously developed a modified ChIP-seq proto...
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Antibody
The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications.
Published: June, 2020
Abstract: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with pote...
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Antibody
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.
Published: June, 2020
Abstract: Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show...
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MagMeDIP kit Antibody
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Published: June, 2020
Abstract: Improving early cancer detection has the potential to substantially reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) is a highly sensitive assay capable of detecting early-s...
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MagMeDIP kit Antibody IPure kit

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