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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

The transcription factor FOXM1 is a cellular target of the natural ...
Published: September, 2011
Abstract: Transcription factors are proteins that bind specifically to defined DNA sequences to promote gene expression. Targeting transcription factors with... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Disruption of the histone acetyltransferase MYST4 leads to a Noonan...
Published: September, 2011
Abstract: Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. According... Read more »
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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit
Genome-scale analysis of metazoan replication origins reveals their...
Published: September, 2011
Abstract: In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature rem... Read more »
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Bioruptor Chromatin Shearing
Improved quantitative and qualitative production of single-domain i...
Published: September, 2011
Abstract: Camelidae single domain antibodies (VHHs) have structural and binding features that render them suitable alternatives to conventional IgG antibodie... Read more »
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Bioruptor Cell Lysis
Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B i...
Published: September, 2011
Abstract: The role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon. The hallmark of cancer... Read more »
Lineage-specific distribution of high levels of genomic 5-hydroxyme...
Published: September, 2011
Abstract: Methylation of cytosine is a DNA modification associated with gene repression. Recently, a novel cytosine modification, 5-hydroxymethylcytosine (5-... Read more »
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Antibody
Smad3-mediated upregulation of miR-21 promotes renal fibrosis.
Published: September, 2011
Abstract: TGF-β/Smad signaling plays a role in fibrogenesis, but therapies targeting TGF-β are ineffective in treating renal fibrosis. Here, we explored the ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
PROMoter uPstream Transcripts share characteristics with mRNAs and ...
Published: September, 2011
Abstract: PROMoter uPstream Transcripts (PROMPTs) were identified as a new class of human RNAs, which are heterologous in length and produced only upstream o... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Effects of genome architecture and epigenetic factors on susceptibi...
Published: September, 2011
Abstract: Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome arc... Read more »
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Antibody
High-throughput sequencing of complete human mtDNA genomes from the...
Published: September, 2011
Abstract: To investigate the demographic history of human populations from the Caucasus and surrounding regions, we used high-throughput sequencing to genera... Read more »
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DNA shearing Bioruptor
Coactivation of GR and NFKB alters the repertoire of their binding ...
Published: September, 2011
Abstract: Glucocorticoid receptor (GR) exerts anti-inflammatory action in part by antagonizing proinflammatory transcription factors such as the nuclear fact... Read more »
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Antibody
Differential patterns of intronic and exonic DNA regions with respe...
Published: August, 2011
Abstract: ABSTRACT: BACKGROUND: The generation of mature mRNAs involves interconnected processes, including transcription by RNA polymerase II (Pol II), mod... Read more »
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Bioruptor Chromatin Shearing
Anthracyclines induce the accumulation of mutant p53 through E2F1-d...
Published: August, 2011
Abstract: Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and A...
Published: August, 2011
Abstract: Alternative splicing and post-translational modifications are processes that give rise to the complexity of the proteome. The nuclear ATF7 and ATF2... Read more »
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Bioruptor Cell Lysis Bioruptor Plus
Selective autophagy regulates insertional mutagenesis by the Ty1 re...
Published: August, 2011
Abstract: Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells. Autophagy is indu... Read more »
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Antibody
SIRT6 is required for maintenance of telomere position effect in hu...
Published: August, 2011
Abstract: In Saccharomyces cerevisiae, the repressive chromatin environment at telomeres gives rise to telomere position effect (TPE), the epigenetic silenci... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree ...
Published: August, 2011
Abstract: Charcot-Marie-Tooth disease is characterized by length-dependent axonal degeneration with distal sensory loss and weakness, deep-tendon-reflex abno... Read more »
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DNA shearing Bioruptor
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase an...
Published: August, 2011
Abstract: The human tumour antigen PRAME (preferentially expressed antigen of melanoma) is frequently overexpressed in tumours. High PRAME levels correlate w... Read more »
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Carboxyl-terminal truncated HBx regulates a distinct microRNA trans...
Published: August, 2011
Abstract: BACKGROUND: The biological pathways and functional properties by which misexpressed microRNAs (miRNAs) contribute to liver carcinogenesis have been... Read more »
The X-inactivation trans-activator Rnf12 is negatively regulated by...
Published: August, 2011
Abstract: X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the mor... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
EVI1-mediated down regulation of MIR449A is essential for the survi...
Published: August, 2011
Abstract: Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated w... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR HighCell ChIP kit
Polycomb eviction as a new distant enhancer function.
Published: August, 2011
Abstract: Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly u... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Long-range epigenetic silencing associates with deregulation of Ika...
Published: August, 2011
Abstract: Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent silencing of transcri... Read more »
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Bioruptor Chromatin Shearing
Systematic bias in high-throughput sequencing data and its correcti...
Published: August, 2011
Abstract: Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of tota... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Histone tails regulate DNA methylation by allosterically activating...
Published: August, 2011
Abstract: Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylatio... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Analysis of HP1α regulation in human breast cancer cells.
Published: August, 2011
Abstract: The three mammalian HP1 proteins, HP1α/CBX5, HP1β/CBX1, and HPγ/CBX3, are involved in chromatin packing and gene regulation. The HP1α protein is do... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Coordination of KSHV latent and lytic gene control by CTCF-cohesin ...
Published: August, 2011
Abstract: Herpesvirus persistence requires a dynamic balance between latent and lytic cycle gene expression, but how this balance is maintained remains enigm... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Gcn5 facilitates Pol II progression, rather than recruitment to nuc...
Published: August, 2011
Abstract: In the fission yeast, the MAP kinase Sty1 and the transcription factor Atf1 regulate up to 400 genes in response to environmental signals, and both... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Mammalian Gcm genes induce Hes5 expression by active DNA demethylat...
Published: August, 2011
Abstract: Signaling mediated by Notch receptors is crucial for the development of many organs and the maintenance of various stem cell populations. The activ... Read more »
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LowCell ChIP kit
Temporal uncoupling of the DNA methylome and transcriptional repres...
Published: August, 2011
Abstract: DNA methylation is a tightly regulated epigenetic mark associated with transcriptional repression. Next-generation sequencing of purified methylate... Read more »
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MeDIP kit

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