Serine Deprivation Enhances Anti-neoplastic Activity of Biguanides. Published: November, 2014 Abstract:
Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits anti-neoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. . There are ongoing clinical trials to evaluat... Read more »
Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. Published: October, 2013 Abstract:
Viruses that generate capped RNA lacking 2'O methylation on the first ribose are severely affected by the antiviral activity of Type I interferons. We used proteome-wide affinity purification coupled to mass spectrometry to identify human and mous... Read more »
Simultaneous quantitative analysis of N-acylethanolamides in clinical samples. Published: December, 2009 Abstract:
A simple and rapid analytical method is described for the simultaneous quantitative analysis of three different N-acylethanolamides in human biological samples: anandamide (AEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). The metho... Read more »
Step-by-step preparation of proteins for mass spectrometric analysis. Abstract:
Nowadays, identification of proteins from biological samples by mass spectrometry is widely used. In principle there are two scenarios. Proteins are pre-fractionated in some way, e.g. by gel electrophoresis or are analyzed as complex mixture (shot... Read more »
