DNA methylation programming and reprogramming in primate embryonic stem cells. Published: December, 2009 Abstract:
DNA methylation is an important epigenetic mechanism, affecting normal development and playing a key role in reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation patterns in native monkey embryonic stem cells (ES... Read more » Tags Antibody
An oestrogen-receptor-alpha-bound human chromatin interactome. Published: November, 2009 Abstract:
Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind to regulatory DNA elements distant from gene promoters... Read more » Tags Antibody
Rapid antibody selection by mRNA display on a microfluidic chip. Published: May, 2009 Abstract:
In vitro antibody-display technologies are powerful approaches for isolating monoclonal antibodies from recombinant antibody libraries. However, these display techniques require several rounds of affinity selection which is time-consuming. Here, w... Read more » Tags Cell Lysis
Genome-wide high throughput analysis of DNA methylation in eukaryotes. Published: March, 2009 Abstract:
Cytosine methylation is the quintessential epigenetic mark. Two well-established methods, bisulfite sequencing and methyl-DNA immunoprecipitation (MeDIP) lend themselves to the genome-wide analysis of DNA methylation by high throughput sequencing.... Read more » Tags Antibody
TBP2 is a substitute for TBP in Xenopus oocyte transcription. Published: January, 2009 Abstract:
BACKGROUND: TATA-box-binding protein 2 (TBP2/TRF3) is a vertebrate-specific paralog of TBP that shares with TBP a highly conserved carboxy-terminal domain and the ability to bind the TATA box. TBP2 is highly expressed in oocytes whereas TBP is mor... Read more » Tags Antibody
