TAL effector-mediated genome visualization (TGV). Published: April, 2014 Abstract:
The three-dimensional remodeling of chromatin within nucleus is being recognized as determinant for genome regulation. Recent technological advances in live imaging of chromosome loci begun to explore the biological roles of the movement of the ch... Read more » Tags Antibody
An increase in MECP2 dosage impairs neural tube formation. Published: March, 2014 Abstract:
Epigenetic mechanisms are fundamental for shaping the activity of the central nervous system (CNS). Methyl-CpG binding protein 2 (MECP2) acts as a bridge between methylated DNA and transcriptional effectors responsible for differentiation programs... Read more » Tags Antibody
Immune evasion by oncogenic proteins of acute myeloid leukemia. Published: March, 2014 Abstract:
PML-RARA and AML1-ETO are important oncogenic fusion proteins that play a central role in transformation to acute myeloid leukemia (AML). Whether these fusion proteins render the tumor cells with immune evasion properties is unknown. Here we show ... Read more » Tags Antibody
Principles of nucleation of H3K27 methylation during embryonic development. Published: March, 2014 Abstract:
During embryonic development, maintenance of cell identity and lineage commitment requires the Polycomb-group PRC2 complex, which catalyzes histone H3 lysine 27 trimethylation (H3K27me3). However, the developmental origins of this regulation are u... Read more » Tags Antibody
