Transcriptome-wide distribution and function of RNA hydroxymethylcytosine Published: January, 2016 Abstract:
Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, ... Read more » Tags Antibody
Functional characterization of the hGRαT556I causing Chrousos syndrome Published: January, 2016 Abstract:
BACKGROUND:
Chrousos syndrome is a rare pathologic condition characterized by generalized, partial resistance of target tissues to glucocorticoids and caused by inactivating mutations of the human glucocorticoid receptor (hGR) gene. A novel case ... Read more » Tags Antibody
Embryonic transcription is controlled by maternally defined chromatin state Published: December, 2015 Abstract:
Histone-modifying enzymes are required for cell identity and lineage commitment, however little is known about the regulatory origins of the epigenome during embryonic development. Here we generate a comprehensive set of epigenome reference maps, ... Read more » Tags Antibody
Oxidative DNA damage in mouse sperm chromosomes: Size matters. Published: December, 2015 Abstract:
Normal embryo and foetal development as well as the health of the progeny are mostly dependent on gamete nuclear integrity. In the present study, in order to characterize more precisely oxidative DNA damage in mouse sperm we used two mouse models ... Read more » Tags Antibody
Transient generalized glucocorticoid hypersensitivity Published: December, 2015 Abstract:
BACKGROUND:
Transient generalized glucocorticoid hypersensitivity is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypo-activation of the hypothalamic-pituitary-adrenal axis. The condition itsel... Read more » Tags Antibody
CRISPR-Mediated Gene Targeting of Human Induced Pluripotent Stem Cells Published: November, 2015 Abstract:
CRISPR/Cas9 nuclease systems can create double-stranded DNA breaks at specific sequences to efficiently and precisely disrupt, excise, mutate, insert, or replace genes. However, human embryonic stem cells and induced pluripotent stem cells (iPSCs)... Read more » Tags Antibody
