Immunometabolic Pathways in BCG-Induced Trained Immunity Published: December, 2016 Abstract:
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such ... Read more » Tags Antibody
Potent and selective bivalent inhibitors of BET bromodomains Published: December, 2016 Abstract:
Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biological targets. BET proteins contain two separate bromodomains, and existing inhibitors bind to them mo... Read more » Tags Antibody
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells Published: November, 2016 Abstract:
The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin properties. These regions exhibit low levels of gene expression, yet the mechanisms controlling these... Read more » Tags BioruptorAntibody
Reader domain specificity and lysine demethylase-4 family function Published: November, 2016 Abstract:
The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 family targets specific chromatin regions is largely unknown. Here, an extensive histone peptide micr... Read more » Tags Antibody
TET2 binds the androgen receptor and loss is associated with prostate cancer Published: November, 2016 Abstract:
Genetic alterations associated with prostate cancer (PCa) may be identified by sequencing metastatic tumour genomes to identify molecular markers at this lethal stage of disease. Previously, we characterized somatic alterations in metastatic tumou... Read more » Tags Antibody
Neonatal monocytes exhibit a unique histone modification landscape Published: September, 2016 Abstract:
Background
Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptible to infections, but the factors regulating neonatal-specific immune responses are poorly understoo... Read more » Tags Antibody
