RNA sequestration in P-bodies sustains myeloid leukaemia Published: August, 2024 Abstract:
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide... Read more » Tags AntibodyCUT&Tag
LL37/self-DNA complexes mediate monocyte reprogramming Published: August, 2024 Abstract:
LL37 alone and in complex with self-DNA triggers inflammatory responses in myeloid cells and plays a crucial role in the development of systemic autoimmune diseases, like psoriasis and systemic lupus erythematosus. We demonstrated that LL37/self-D... Read more » Tags Antibody
KRAS promotes GLI2-dependent transcription during pancreatic carcinogenesis Published: June, 2024 Abstract:
Aberrant activation of GLI transcription factors has been implicated in the pathogenesis of different tumor types including pancreatic ductal adenocarcinoma (PDAC). However, the mechanistic link with established drivers of this disease remains in ... Read more » Tags Antibody
