H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation. Published: December, 2019 Abstract:
Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflammation... Read more » Tags Antibody
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells. Published: November, 2019 Abstract:
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal, proliferation,... Read more » Tags Antibody
R-Loops Promote Antisense Transcription across the Mammalian Genome Published: November, 2019 Abstract:
Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these a... Read more » Tags Antibody
TET2 Regulates the Neuroinflammatory Response in Microglia. Published: October, 2019 Abstract:
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflammatory ... Read more » Tags Antibody
