Diagenode

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.


Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ

Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.

Tags
Bioruptor
Chromatin Shearing
ChIP-qPCR

Share this article

Published
June, 2009

Source

Events

 See all events

Twitter feed

News

 See all news