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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system.
Published: February, 2010
Abstract: A variety of chromatin remodeling complexes are thought to orchestrate transcriptional programs that lead neuronal precursors from earliest commitment to terminal differentiation. Here we show that mammalian neurons have a specialized chromatin re...
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Antibody
PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.
Published: February, 2010
Abstract: Many different molecular mechanisms have been associated with PML-RARalpha-dependent transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARalpha binding sites in an acute promyelocytic leukemia (APL) cell line and...
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IP-Star Antibody RARalpha (C15310155)
Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z.
Published: February, 2010
Abstract: ATP-dependent chromatin remodeling complexes rearrange nucleosomes by altering the position of DNA around the histone octamer. Although chromatin remodelers and the histone variant H2A.Z colocalize on transcriptional control regions, whether H2A.Z...
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Antibody
AGRONOMICS1: a new resource for Arabidopsis transcriptome profiling.
Published: February, 2010
Abstract: Transcriptome profiling has become a routine tool in biology. For Arabidopsis (Arabidopsis thaliana), the Affymetrix ATH1 expression array is most commonly used, but it lacks about one-third of all annotated genes present in the reference strain. ...
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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing.
Published: January, 2010
Abstract: BACKGROUND: Cancer cells undergo massive alterations to their DNA methylation patterns that result in aberrant gene expression and malignant phenotypes. However, the mechanisms that underlie methylome changes are not well understood nor is the gen...
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Antibody
The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes.
Published: January, 2010
Abstract: Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the dynamics of viral chromatin at early timepoints of latent infection are poorly understood. Here, we report a comprehensive spatial and temporal analysis o...
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DNA shearing Bioruptor Chromatin Shearing Antibody
In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications.
Published: January, 2010
Abstract: BACKGROUND: The folding of genetic information into chromatin plays important regulatory roles in many nuclear processes and particularly in gene transcription. Post translational histone modifications are associated with specific chromatin conden...
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Antibody
The core binding factor CBF negatively regulates skeletal muscle terminal differentiation.
Published: January, 2010
Abstract: BACKGROUND: Core Binding Factor or CBF is a transcription factor composed of two subunits, Runx1/AML-1 and CBF beta or CBFbeta. CBF was originally described as a regulator of hematopoiesis. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that CBF is ...
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Bioruptor Antibody
UPF2 is a critical regulator of liver development, function and regeneration.
Published: January, 2010
Abstract: BACKGROUND: Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise fr...
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Antibody
Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression.
Published: January, 2010
Abstract: BACKGROUND: NF-kappaB regulates the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis, cell proliferation, differentiation and survival. We have earlier reported that p65, a subunit of NF-kapp...
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Bioruptor Chromatin Shearing ChIP-qPCR
Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated.
Published: January, 2010
Abstract: BACKGROUND: DNA methylation can regulate gene expression by modulating the interaction between DNA and proteins or protein complexes. Conserved consensus motifs exist across the human genome ("predicted transcription factor binding sites": "predic...
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DNA shearing Bioruptor Antibody
Chromatin states of core pluripotency-associated genes in pluripotent, multipotent and differentiated cells.
Published: January, 2010
Abstract: Oct4, Nanog and Sox2 constitute a core of transcription factors controlling pluripotency. Differentiation and reprogramming studies have unraveled a few epigenetic modifications associated in relation to the expression state of OCT4, NANOG and SOX...
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Antibody
DNA methylation programming and reprogramming in primate embryonic stem cells.
Published: December, 2009
Abstract: DNA methylation is an important epigenetic mechanism, affecting normal development and playing a key role in reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation patterns in native monkey embryonic stem cells (ES...
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Antibody
An oestrogen-receptor-alpha-bound human chromatin interactome.
Published: November, 2009
Abstract: Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind to regulatory DNA elements distant from gene promoters...
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Antibody
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.
Published: November, 2009
Abstract: Instructive mechanisms are present for induction of DNA methylation, as shown by methylation of specific CpG islands (CGIs) by specific inducers and in specific cancers. However, instructive factors involved are poorly understood, except for invol...
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Antibody
The histone variant macroH2A is an epigenetic regulator of key developmental genes.
Published: October, 2009
Abstract: The histone variants macroH2A1 and macroH2A2 are associated with X chromosome inactivation in female mammals. However, the physiological function of macroH2A proteins on autosomes is poorly understood. Microarray-based analysis in human male pluri...
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Antibody H3K4me3 (C15410003)
Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis.
Published: October, 2009
Abstract: In DNA methylation microarray analysis, quantitative assessment of intermediate methylation levels in samples with various global methylation levels is still difficult. Here, specifically for methylated DNA immunoprecipitation-CpG island (CGI) mic...
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Antibody
Sox3: a transcription factor for Cyp19 expression in the frog Rana rugosa.
Published: September, 2009
Abstract: Cyp19 is expressed at a high level in the gonad of the female tadpole of the frog Rana rugosa during sex determination. To identify sequence elements important for expression of Cyp19, we isolated a genomic clone (approximately 40 kbp) carrying R....
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LowCell ChIP kit
Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.
Published: September, 2009
Abstract: Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune respo...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Functional connection between deimination and deacetylation of histones.
Published: September, 2009
Abstract: Histone methylation plays key roles in regulating chromatin structure and function. The recent identification of enzymes that antagonize or remove histone methylation offers new opportunities to appreciate histone methylation plasticity in the reg...
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Bioruptor Chromatin Shearing Cell Lysis Antibody
A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos.
Published: September, 2009
Abstract: Epigenetic mechanisms set apart the active and inactive regions in the genome of multicellular organisms to produce distinct cell fates during embryogenesis. Here, we report on the epigenetic and transcriptome genome-wide maps of gastrula-stage Xe...
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Antibody
High-resolution analysis of epigenetic changes associated with X inactivation.
Published: August, 2009
Abstract: Differentiation of female murine ES cells triggers silencing of one X chromosome through X-chromosome inactivation (XCI). Immunofluorescence studies showed that soon after Xist RNA coating the inactive X (Xi) undergoes many heterochromatic changes...
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Antibody H3K4me3 (C15410003)
H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming.
Published: July, 2009
Abstract: Histone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64 (H3K64me3) as a modification ...
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Antibody H3K4me3 (C15410003)
Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells.
Published: June, 2009
Abstract: Long-term culture of mesenchymal stem cells leads to a loss of differentiation capacity, the molecular mechanism of which remains not understood. We show here that expansion of adipose stem cells (ASCs) to late passage (replicative senescence) is ...
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Antibody LowCell ChIP kit
Rapid antibody selection by mRNA display on a microfluidic chip.
Published: May, 2009
Abstract: In vitro antibody-display technologies are powerful approaches for isolating monoclonal antibodies from recombinant antibody libraries. However, these display techniques require several rounds of affinity selection which is time-consuming. Here, w...
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Cell Lysis
Genome-wide high throughput analysis of DNA methylation in eukaryotes.
Published: March, 2009
Abstract: Cytosine methylation is the quintessential epigenetic mark. Two well-established methods, bisulfite sequencing and methyl-DNA immunoprecipitation (MeDIP) lend themselves to the genome-wide analysis of DNA methylation by high throughput sequencing....
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Antibody
Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa.
Published: March, 2009
Abstract: Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa s...
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Antibody
Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.
Published: January, 2009
Abstract: Spinal muscular atrophy (SMA), a common neuromuscular disorder, is caused by homozygous absence of the survival motor neuron gene 1 (SMN1), while the disease severity is mainly influenced by the number of SMN2 gene copies. This correlation is not ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules.
Published: January, 2009
Abstract: BACKGROUND: Thioredoxin interacting protein (Txnip) is a multifunctional protein involved in regulation of cell cycle events and cellular metabolism. The expression of Txnip is known to be induced by glucose, adenosine-containing molecules, and ot...
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Antibody
TBP2 is a substitute for TBP in Xenopus oocyte transcription.
Published: January, 2009
Abstract: BACKGROUND: TATA-box-binding protein 2 (TBP2/TRF3) is a vertebrate-specific paralog of TBP that shares with TBP a highly conserved carboxy-terminal domain and the ability to bind the TATA box. TBP2 is highly expressed in oocytes whereas TBP is mor...
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Antibody

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