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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
The histone methyltransferase Dot1 is required for DNA damage repair and proper development in Dictyostelium.
Published: January, 2011
Abstract: Posttranslational histone modifications play an important role in modulating gene expression and chromatin structure. Here we report the identification of histone H3K79 dimethylation in the simple eukaryote Dictyostelium discoideum. We have delete...
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Antibody
Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.
Published: January, 2011
Abstract: The Wnt pathway transcription factor T cell factor 1 (TCF-1) plays essential roles in the control of several developmental processes, including T cell development in the thymus. Although previously regarded as being required only during early T ce...
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Antibody LowCell ChIP kit
Characterisation of genome-wide PLZF/RARA target genes.
Published: January, 2011
Abstract: The PLZF/RARA fusion protein generated by the t(11;17)(q23;q21) translocation in acute promyelocytic leukaemia (APL) is believed to act as an oncogenic transcriptional regulator recruiting epigenetic factors to genes important for its transforming...
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Bioruptor Chromatin Shearing Antibody H3K4me3 (C15410003)
Role of p53 serine 46 in p53 target gene regulation.
Published: January, 2011
Abstract: The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive. Here, we have...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells.
Published: January, 2011
Abstract: Nuclear factor of activated T cells (NFAT) is a family of transcription factors composed of five proteins. Among them, NFAT1 is a predominant NFAT protein in CD4(+) T cells. NFAT1 positively regulates transcription of a large number of inducible c...
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DNA shearing Bioruptor Antibody
Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays.
Published: January, 2011
Abstract: UNLABELLED: ABSTRACT: BACKGROUND: The processes that compose expression of a given gene are far more complex than previously thought presenting unprecedented conceptual and mechanistic challenges that require development of new tools. Chromatin st...
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Bioruptor Chromatin Shearing Antibody
Epigenetic regulation of miR-212 expression in lung cancer.
Published: January, 2011
Abstract: Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are ...
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Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications.
Published: January, 2011
Abstract: Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in ...
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Antibody LowCell ChIP kit
Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine "Shoseiryuto (Xiao-Qing-Long-Tang)" on Airway Inflammation in a Mouse Model.
Published: January, 2011
Abstract: Effects of a Kampo (Japanese herbal) medicine "shoseiryuto (SST, xiao-qing-long-tang in Chinese)", which has been used for the treatment of allergic bronchial asthma clinically, were examined on ovalbumin (OVA)-sensitized allergic airway inflammat...
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Tissue Homogenization
Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B.
Published: January, 2011
Abstract: Porcine endogenous retroviruses (PERVs) have been considered one of the major risks of xenotransplantation from pigs to humans. PERV-A efficiently utilizes human PERV-A receptor 2 (HuPAR-2)/GPR172B to infect human cells; however, there has been no...
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Antibody
Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays.
Published: December, 2010
Abstract: BACKGROUND: Uncovering epigenetic states by chromatin immunoprecipitation and microarray hybridization (ChIP-chip) has significantly contributed to the understanding of gene regulation at the genome-scale level. Many studies have been carried out ...
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Antibody H3K4me3 (C15410003)
H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.
Published: December, 2010
Abstract: Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum is poorly understood. Dynamic or stable association of epigenetic ...
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DNA shearing Bioruptor Antibody
Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.
Published: December, 2010
Abstract: The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-term...
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Antibody
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.
Published: December, 2010
Abstract: Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factor...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
Published: December, 2010
Abstract: The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(...
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Antibody
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Published: November, 2010
Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory mili...
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Antibody
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Published: November, 2010
Abstract: Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we developed a culture system using in...
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Antibody
Histone modifications at the blastocyst Axin1(Fu) locus mark the heritability of in vitro culture-induced epigenetic alterations in mice.
Published: November, 2010
Abstract: For epigenetic phenotypes to be passed on from one generation to the next, it is required that epigenetic marks between generations are not cleared during the two stages of epigenetic reprogramming: mammalian gametogenesis and preimplantation deve...
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Antibody LowCell ChIP kit
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.
Published: November, 2010
Abstract: The initiation of DNA synthesis is governed by the licensing of replication origins, which consists of assembling a pre-replication complex (pre-RC) on origins during late M- and G1-phases. In metazoans, functional replication origins do not show ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes.
Published: October, 2010
Abstract: Evidence links pluripotency to a gene regulatory network organized by the transcription factors Oct4, Nanog and Sox2. Expression of these genes is controlled by epigenetic modifications on regulatory regions. However, little is known on profiles o...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Published: October, 2010
Abstract: How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. We identified an inflammation-activated signaling in muscle stem (satellite) cells, by which the polycomb r...
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Antibody
Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.
Published: September, 2010
Abstract: The maternal and paternal genomes possess distinct epigenetic marks that distinguish them at imprinted loci. In order to identify imprinted loci, we used a novel method, taking advantage of the fact that uniparental disomy (UPD) provides a system ...
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Antibody
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
Published: August, 2010
Abstract: Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrounded by an extra-embryonic layer, the trophectoderm. We show that a set of somatic lineage regulators (including Hox, Gata and Sox factors) that carry biv...
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Antibody
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
Published: July, 2010
Abstract: Maintenance of specific heterochromatic domains is crucial for genome stability. In eukaryotic cells, a fraction of the tandem-repeated ribosomal RNA (rRNA) genes is organized in the heterochromatic structures. The principal determinant of rDNA si...
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Antibody Master Mix
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
Published: June, 2010
Abstract: Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to reprogram differentiated cell types to pluripotency upon cellular fusion. Polycomb-group (PcG) proteins are important for restraining the inappropriate expression ...
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Antibody
Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.
Published: June, 2010
Abstract: The current concept of epigenetic repression is based on one repressor unit corresponding to one silent gene. This notion, however, cannot adequately explain concurrent silencing of multiple loci observed in large chromosome regions. The long-rang...
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DNA shearing Chromatin Shearing ChIP-qPCR ChIP-seq Antibody 5mC (C15200081)
det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression.
Published: May, 2010
Abstract: Summary Obligate photoautotrophs such as plants must capture energy from sunlight and are therefore exposed to the damaging collateral effects of ultraviolet (UV) irradiation, especially on DNA. Here we investigated the interconnection between lig...
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Antibody
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
Published: April, 2010
Abstract: Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and...
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Antibody
Autonomous silencing of the imprinted Cdkn1c gene in stem cells
Published: April, 2010
Abstract: Parent-of-origin specific expression of imprinted genes relies on the differential DNA methylation of specific genomic regions. Differentially methylated regions (DMRs) acquire DNA methylation either during gametogenesis (primary DMR) or after fer...
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Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003) Histone ChIP kit
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.
Published: April, 2010
Abstract: Chromodomain proteins (Chp1/Chp2/Swi6/Clr4) bind to methylated H3K9 (H3K9me) and regulate pericentric heterochromatin in fission yeast. Chp1 and Clr4 (H3K9-HMT), bind transcriptionally active heterochromatin, whereas Chp2/Swi6 (HP1 homologs) are r...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

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