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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Dynamic Changes in Ezh2 Gene Occupancy Underlie Its Involvement in Neural Stem Cell Self-Renewal and Differentiation towards Oligodendrocytes
Published: July, 2012
Abstract: Background: The polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells. We previously demonstrated that Ezh2 is also expressed in multipotent...
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Antibody
An essential novel component of the non-canonical mitochondrial outer membrane protein import system of trypanosomatids.
Published: July, 2012
Abstract: The mitochondrial outer membrane protein Tom40 is the general entry gate for imported proteins in essentially all eukaryotes. Trypanosomatids however lack Tom40 and use instead a protein termed the archaic translocase of the outer mitochondrial me...
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Antibody
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers.
Published: June, 2012
Abstract: Enhancers are developmentally controlled transcriptional regulatory regions whose activities are modulated through histone modifications or histone variant deposition. In this study, we show by genome-wide mapping that the newly discovered deoxyri...
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Antibody
Extensive promoter hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia.
Published: June, 2012
Abstract: Dysregulated microRNA (miRNA) expression contributes to the pathogenesis of hematopoietic malignancies, including chronic lymphocytic leukemia (CLL). However, an understanding of the mechanisms that cause aberrant miRNA transcriptional control is ...
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Bioruptor Chromatin Shearing ChIP-qPCR IP-Star Antibody H3K4me3 (C15410003) Bioruptor Plus
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.
Published: June, 2012
Abstract: Chemical manipulations undertaken on some bis(bromo- and dibromo-phenol) compounds previously reported by us as wide-spectrum epigenetic inhibitors let us to identify bis (bromo- and dibromo-methoxyphenyl) derivatives highly selective for PR-SET7 ...
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Antibody
Genome-Wide DNA Methylation Changes between the Superficial and Deep Backfat Tissues of the Pig
Published: June, 2012
Abstract:
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DNA shearing Bioruptor Antibody
Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress
Published: June, 2012
Abstract:
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The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells.
Published: June, 2012
Abstract: Extensive changes in posttranslational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their func...
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Antibody H3K4me3 (C15410003) H3K27me3 (C15410069)
Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes.
Published: June, 2012
Abstract: The transcription factor Sp2 is essential for early mouse development and for proliferation of mouse embryonic fibroblasts in culture. Yet its mechanisms of action and its target genes are largely unknown. In this study, we have combined RNA inter...
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Recruitment of histone deacetylase 3 to the interferon-a gene promoters attenuates interferon expression.
Published: June, 2012
Abstract: BACKGROUND: Induction of Type I Interferon (IFN) genes constitutes an essential step leading to innate immune responses during virus infection. Sendai virus (SeV) infection of B lymphoid Namalwa cells transiently induces the transcriptional expres...
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Antibody
Intronic RNAs mediate EZH2 regulation of epigenetic targets.
Published: June, 2012
Abstract: Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role for some RNA molecules in guiding repressive polycomb complex PRC2 to specific chromatin regions has been proposed. Here we use an in vivo cross-linking ...
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Antibody LowCell ChIP kit H3K4me3 (C15410003) H3K27me3 (C15410069)
Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors.
Published: May, 2012
Abstract: Epigenetic regulation is an essential process for the normal functioning of genes. Therefore, targeting epigenetic dysregulation in cancer may be a valid therapeutic approach for the treatment of this severe disease. Histone deacetylases (HDACs) a...
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Antibody
Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components
Published: May, 2012
Abstract:
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Antibody
Epigenetic Repression of RARRES1 Is Mediated by Methylation of a Proximal Promoter and a Loss of CTCF Binding.
Published: May, 2012
Abstract: BACKGROUND: The cis-acting promoter element responsible for epigenetic silencing of retinoic acid receptor responder 1 (RARRES1) by methylation is unclear. Likewise, how aberrant methylation interplays effectors and thus affects breast neoplastic ...
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Functional Genomic Methods to Study Estrogen Receptor Activity.
Published: May, 2012
Abstract: Estrogen Receptor (ER) is a nuclear receptor that mediates the actions of estrogen and tamoxifen. ER is expressed in a major fraction of human breast cancers. Recently, genomic maps for estrogen- and tamoxifen-ER have been published. Interestingly...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis.
Published: May, 2012
Abstract: The generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the non-coding DNA surrounding their...
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Bioruptor Chromatin Shearing ChIP-seq Antibody
The histone demethylase Kdm3a is essential to progression through differentiation.
Published: May, 2012
Abstract: Histone demethylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity by still poorly understood mechanisms. Here, we examined the role of histone demethylase K...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns.
Published: May, 2012
Abstract: The stability of epigenetic patterns is critical for genome integrity and gene expression. This highly coordinated process involves interrelated positive and negative regulators that impact distinct epigenetic marks, including DNA methylation and ...
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Antibody LowCell ChIP kit
High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation.
Published: May, 2012
Abstract: Chromatin immunoprecipitation (ChIP) is an assay for interrogating protein-DNA interactions that is increasingly being used for drug target discovery and screening applications. Currently the complexity of the protocol and the amount of hands-on t...
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Bioruptor Chromatin Shearing
Environmentally induced epigenetic transgenerational inheritance of ovarian disease.
Published: May, 2012
Abstract: The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbo...
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Antibody
Lxrα Regulates the Androgen Response in Prostate Epithelium.
Published: April, 2012
Abstract: Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulatio...
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Antibody
Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.
Published: April, 2012
Abstract: Human studies suggest that a variety of prenatal stressors are related to high risk for cognitive and behavioral abnormalities associated with psychiatric illness (Markham and Koenig, 2011). Recently, a downregulation in the expression of GABAergi...
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The transcriptional and epigenomic foundations of ground state pluripotency.
Published: April, 2012
Abstract: Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" pos...
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Antibody H3K4me3 (C15410003)
Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment.
Published: April, 2012
Abstract: IL-31 is a T cell-derived cytokine that signals via a heterodimeric receptor composed of IL-31Rα and oncostatin M receptor β. Although several studies have aimed to investigate IL-31-mediated effects, the biological functions of this cytokine are ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change.
Published: April, 2012
Abstract: Microenvironment plays an important role in cancer development. We have reported that the cancer-associated stromal cells exhibit phenotypic and functional changes compared to stromal cells neighboring to normal tissues. However, the molecular mec...
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DNA shearing Bioruptor Antibody
HDAC1 Regulates Fear Extinction in Mice.
Published: April, 2012
Abstract: Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, litt...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
The histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation.
Published: April, 2012
Abstract: BACKGROUND AND AIMS: Transdifferentiation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is a pivotal event that drives liver fibrosis. HSC transdifferentiation requires coordinated global changes in gene expression. Here we ha...
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Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk.
Published: March, 2012
Abstract: Cross-talk between DNA methylation and histone modifications drives the establishment of composite epigenetic signatures and is traditionally studied using correlative rather than direct approaches. Here we present sequential ChIP-bisulfite-sequen...
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DNA shearing Bioruptor Chromatin Shearing ChIP-seq Antibody
C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.
Published: March, 2012
Abstract: To elucidate the molecular mechanism underlying the endochondral ossification process during the skeletal growth and osteoarthritis (OA) development, we examined the signal network around CCAAT/enhancer-binding protein-β (C/EBPβ, encoded by CEBPB)...
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Antibody
Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence.
Published: February, 2012
Abstract: BACKGROUND: In the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex chromosomes, we compared th...
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Antibody H3K27me3 (C15410069)

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