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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System.
Published: December, 2012
Abstract: The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, ...
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Antibody
Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
Published: December, 2012
Abstract: Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon sam...
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IP-Star Antibody
Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation.
Published: November, 2012
Abstract: Tissue generation and repair requires a stepwise process of cell fate restriction to ensure adult stem cells differentiate in a timely and appropriate manner. A crucial role has been implicated for Polycomb-group (PcG) proteins and the H3K27me3 re...
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Bioruptor Chromatin Shearing ChIP-seq Antibody H3K4me3 (C15410003)
Ash2 acts as an Ecdysone Receptor coactivator by stabilizing the histone methyltransferase Trr.
Published: November, 2012
Abstract: The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-...
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Antibody
Limitations and possibilities of low cell number ChIP-seq.
Published: November, 2012
Abstract: ABSTRACT: BACKGROUND: Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-seq) offers high resolution, genome-wide analysis of DNA-protein interactions. However, current standard methods require abundant starting materi...
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Bioruptor Chromatin Shearing ChIP-seq Antibody H3K4me3 (C15410003)
Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair.
Published: November, 2012
Abstract: Protein modification by SUMO affects a wide range of protein substrates. Surprisingly, although SUMO pathway mutants display strong phenotypes, the function of individual SUMO modifications is often enigmatic, and SUMOylation-defective mutants com...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003)
Inhibition of Tumor Promotion by Parthenolide: Epigenetic Modulation of p21.
Published: November, 2012
Abstract: The promotion stage in the multistep process of epidermal tumorigenesis is NF-кB-dependent, epigenetically regulated, and reversible, thus, a suitable target for chemoprevention. We investigated whether the NF-кB inhibitor, parthenolide, currently...
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Antibody
Thalamus-derived molecules promote survival and dendritic growth of developing cortical neurons.
Published: October, 2012
Abstract: The mammalian neocortex is composed of various types of neurons that reflect its laminar and area structures. It has been suggested that not only intrinsic but also afferent-derived extrinsic factors are involved in neuronal differentiation during...
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Antibody
IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer.
Published: October, 2012
Abstract: BACKGROUND: IL-23 is a member of the IL-6 super-family and plays key roles in cancer. Very little is currently known about the role of IL-23 in non-small cell lung cancer (NSCLC). METHODS: RT-PCR and chromatin immunopreciptiation (ChIP) were used ...
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Antibody H3K4me3 (C15410003)
High-resolution detection of DNA binding sites of the global transcriptional regulator GlxR in Corynebacterium glutamicum.
Published: October, 2012
Abstract: The transcriptional regulator GlxR has been characterised as a global hub within the gene-regulatory network of Corynebacterium glutamicum. Chromatin immunoprecipitation with a specific anti-GlxR antibody and subsequent high-throughput sequencing ...
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Bioruptor Chromatin Shearing ChIP-seq
Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study.
Published: October, 2012
Abstract: ABSTRACT: INTRODUCTION: The association between rheumatoid arthritis (RA) and periodontitis is suggested to be linked to the periodontal pathogen Porphyromonas gingivalis. Colonization of P. gingivalis in the oral cavity of RA patients has been sc...
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Bioruptor Cell Lysis Enzymatic Assay
New partners in regulation of gene expression: the enhancer of trithorax and polycomb corto interacts with methylated ribosomal protein l12 via its chromodomain.
Published: October, 2012
Abstract: Chromodomains are found in many regulators of chromatin structure, and most of them recognize methylated lysines on histones. Here, we investigate the role of the Drosophila melanogaster protein Corto's chromodomain. The Enhancer of Trithorax and ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003) H3K27me3 (C15410069) IPure kit
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.
Published: October, 2012
Abstract: ABSTRACT: BACKGROUND: Induction and promotion of liver cancer by exposure to non-genotoxic carcinogens coincides with epigenetic perturbations, including specific changes in DNA methylation. Here we investigate the genome-wide dynamics of 5-hydro...
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DNA shearing Bioruptor Antibody
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Published: October, 2012
Abstract: A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically ...
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Antibody
Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation.
Published: October, 2012
Abstract: The rate of meiotic crossing over (CO) varies considerably along chromosomes, leading to marked distortions between physical and genetic distances. The causes underlying this variation are being unraveled, and DNA sequence and chromatin states hav...
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DNA shearing Bioruptor Antibody
Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.
Published: October, 2012
Abstract: The endocrine disruptor vinclozolin has previously been shown to promote epigenetic transgenerational inheritance of adult onset disease in the rat. The current study was designed to investigate the transgenerational actions of vinclozolin on the ...
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Antibody
ChIP-exo Method for Identifying Genomic Location of DNA-Binding Proteins with Near-Single-Nucleotide Accuracy.
Published: October, 2012
Abstract: This unit describes the ChIP-exo methodology, which combines chromatin immunoprecipitation (ChIP) with lambda exonuclease digestion followed by high-throughput sequencing. ChIP-exo allows identification of a nearly complete set of the binding loca...
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Bioruptor Chromatin Shearing ChIP-seq
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.
Published: September, 2012
Abstract: A fundamental challenge in mammalian biology has been the elucidation of mechanisms linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin-like PHD and RING finger domain-containing 1) has multiple domains tha...
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Antibody 5mC (C15200081)
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.
Published: September, 2012
Abstract: Adaptive features of innate immunity, recently described as "trained immunity," have been documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show that bacille Calmette-Guérin (BCG) vaccination in healthy volunteer...
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Antibody
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Published: September, 2012
Abstract: p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulat...
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Antibody
ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia.
Published: September, 2012
Abstract: ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and maintenance of normal hematopoietic stem cells. Here, genome-wide analysis revealed that both ER...
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IP-Star Antibody
H4K20me1 Contributes to Downregulation of X-Linked Genes for C. elegans Dosage Compensation
Published: September, 2012
Abstract: The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in ...
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Antibody
Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells.
Published: September, 2012
Abstract: The methylcytosine hydroxylase Tet2 has been implicated in hematopoietic differentiation and the formation of myeloid malignancies when mutated. An ideal system to study the role of Tet2 in myelopoeisis is CEBPα-induced transdifferentiation of pre...
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DNA shearing Bioruptor Antibody
Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations.
Published: September, 2012
Abstract: Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) pro...
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Antibody
Multigenerational epigenetic adaptation of the hepatic wound-healing response.
Published: September, 2012
Abstract: We investigated whether ancestral liver damage leads to heritable reprogramming of hepatic wound healing in male rats. We found that a history of liver damage corresponds with transmission of an epigenetic suppressive adaptation of the fibrogenic ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K27me3 (C15410069)
Chromatin accessibility, p300 and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia.
Published: August, 2012
Abstract: Chromatin accessibility plays a key role in regulating cell type specific gene expression during hematopoiesis, but has also been suggested to be aberrantly regulated during leukemogenesis. To understand the leukemogenic chromatin signature we ana...
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Antibody
Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes.
Published: August, 2012
Abstract: Immunological memory in vertebrates is often exclusively attributed to T and B cell function. Recently it was proposed that the enhanced and sustained innate immune responses following initial infectious exposure may also afford protection against...
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Antibody
Histone acetylation and DNA demethylation of T-cells result in an anaplastic large cell lymphoma-like phenotype.
Published: August, 2012
Abstract: Background. A characteristic feature of anaplastic large cell lymphoma is the significant repression of the T-cell expression program despite its T-cell origin. The reasons for this down-regulation of T-cell phenotype are still unknown. Design and...
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Antibody 5mC (C15200081)
The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME.
Published: August, 2012
Abstract: The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways ...
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Antibody
A Sharp Cadherin-6 Gene Expression Boundary in the Developing Mouse Cortical Plate Demarcates the Future Functional Areal Border.
Published: August, 2012
Abstract: The mammalian cerebral cortex can be tangentially subdivided into tens of functional areas with distinct cyto-architectures and neural circuitries; however, it remains elusive how these areal borders are genetically elaborated during development. ...
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Antibody

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