Diagenode
| United States | My cart | 登录 / 注册 搜索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.
Published: May, 2013
Abstract: Growing evidence suggests epigenetic alteration is involved during the development and progression of prostate cancer. Previously, we found Nrf2, a key regulator of cellular antioxidant defense systems, was silenced through epigenetic mechanism du...
Read more »
Tags
DNA shearing Bioruptor Chromatin Shearing ChIP-qPCR MagMeDIP kit
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Published: May, 2013
Abstract: LXR (Liver X Receptors) act as "sensor" proteins that regulate cholesterol uptake, storage, and efflux. LXR signaling is known to influence proliferation of different cell types including human prostatic carcinoma (PCa) cell lines. This study show...
Read more »
Tags
Antibody
Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish.
Published: May, 2013
Abstract: BACKGROUND: Zebrafish embryos are transcriptionally silent until activation of the zygotic genome during the 10th cell cycle. Onset of transcription is followed by cellular and morphological changes involving cell speciation and gastrulation. Prev...
Read more »
Tags
Antibody
First evidence of DNA methylation in insect Tribolium castaneum: environmental regulation of DNA methylation within heterochromatin.
Published: May, 2013
Abstract: DNA methylation has been studied in many eukaryotic organisms, in particular vertebrates, and was implicated in developmental and phenotypic variations. Little is known about the role of DNA methylation in invertebrates, although insects are consi...
Read more »
Tags
Antibody
G-quadruplex structures are stable and detectable in human genomic DNA.
Published: April, 2013
Abstract: The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome for transcriptional regulation, DNA replication and genome stability, but the nature and distribution of G-quadruplexes...
Read more »
Tags
DNA shearing Bioruptor
Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.
Published: April, 2013
Abstract: The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but ...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-seq Antibody
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1.
Published: April, 2013
Abstract: EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a transcriptionally repressive post-translational modification. Overex...
Read more »
Tags
Antibody
The developmental epigenomics toolbox: ChIP-seq and MethylCap-seq profiling of early zebrafish embryos.
Published: April, 2013
Abstract: Genome-wide profiling of DNA methylation and histone modifications answered many questions as to how the genes are regulated on a global scale and what their epigenetic makeup is. Yet, little is known about the function of these marks during early...
Read more »
Tags
DNA shearing Bioruptor Chromatin Shearing ChIP-seq Antibody MethylCap H3K4me3 (C15410003)
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells.
Published: April, 2013
Abstract: Embryonic development requires chromatin remodeling for dynamic regulation of gene expression patterns to ensure silencing of pluripotent transcription factors and activation of developmental regulators. Demethylation of H3K27me3 by the histone de...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.
Published: April, 2013
Abstract: Increased physiological levels of oxysterols are major risk factors for developing atherosclerosis and cardiovascular disease. Lipid-loaded macrophages, termed foam cells, are important during the early development of atherosclerotic plaques. To p...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR ChIP-seq Antibody H3K4me3 (C15410003)
The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.
Published: March, 2013
Abstract: The hormone gastrin physiologically regulates gastric acid secretion and also contributes to maintaining gastric epithelial architecture by regulating expression of genes such as plasminogen activator inhibitor 2 (PAI-2) and regenerating protein 1...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus
Epigenetic hierarchy within the MAGEA1 cancer-germline gene: promoter DNA methylation dictates local histone modifications.
Published: March, 2013
Abstract: Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA methylation for repression in somatic tissues. Many of these genes, termed cancer-germline (CG) genes, become demethylated and activated in a wide variety of tumors, ...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Naive pluripotency is associated with global DNA hypomethylation.
Published: March, 2013
Abstract: Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively. We investigated whether differences exist between ESCs and EGCs, in view of...
Read more »
Tags
Antibody 5mC (C15200081)
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
Published: February, 2013
Abstract: DNA methylation in mammals is highly dynamic during germ cell and preimplantation development but is relatively static during the development of somatic tissues. 5-hydroxymethylcytosine (5hmC), created by oxidation of 5-methylcytosine (5mC) by Tet...
Read more »
Tags
Antibody
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
Published: February, 2013
Abstract: Histone modifications are key regulators of chromatin function. However, little is known to what extent histone modifications can directly impact on chromatin. Here, we address how a modification within the globular domain of histones regulates ch...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003)
Identification of thyroid hormone response elements in vivo using mice expressing a tagged thyroid hormone receptor alpha 1.
Published: February, 2013
Abstract: Thyroid hormone receptor alpha 1 (TRα1) is well recognized for its importance in brain development. However, due to the difficulties in predicting thyroid hormone response elements (TREs) in silico and the lack of suitable antibodies against TRα1 ...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR
SUMOylation of the inducible (c-Fos:c-Jun)/AP-1 transcription complex occurs on target promoters to limit transcriptional activation.
Published: February, 2013
Abstract: The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes. It is tightly controlled at multiple levels to avoid the deleterious effects of ...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR
DNA methylation analysis in the intestinal epithelium-effect of cell separation on gene expression and methylation profile.
Published: February, 2013
Abstract: BACKGROUND: Epigenetic signatures are highly cell type specific. Separation of distinct cell populations is therefore desirable for all epigenetic studies. However, to date little information is available on whether separation protocols might infl...
Read more »
Tags
DNA shearing Bioruptor Antibody 5mC (C15200081)
DNA methylation mediated control of gene expression is critical for development of crown gall tumors.
Published: February, 2013
Abstract: Crown gall tumors develop after integration of the T-DNA of virulent Agrobacterium tumefaciens strains into the plant genome. Expression of the T-DNA-encoded oncogenes triggers proliferation and differentiation of transformed plant cells. Crown ga...
Read more »
Tags
DNA shearing Bioruptor Antibody
Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines.
Published: February, 2013
Abstract: AIM: The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understa...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR IP-Star Antibody H3K4me3 (C15410003) HighCell ChIP kit H3K27me3 (C15410069) IP-Star Compact
Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression
Published: January, 2013
Abstract: E-cadherin expression is repressed by ZEB2/SIP1 while it is induced by KLF4. Independent data from the literature indicate that these two transcription factors could bind close to each other in the proximal region of the E-cadherin gene promoter. ...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA.
Published: January, 2013
Abstract: How a more plastic chromatin state is maintained and reversed during development is unknown. Heterochromatin-mediated silencing of repetitive elements occurs in differentiated cells. Here, we used repetitive elements, including retrotransposons, a...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003)
Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
Published: January, 2013
Abstract: Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritanc...
Read more »
Tags
Antibody
Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Published: January, 2013
Abstract: Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to d...
Read more »
Tags
Antibody
The N-terminal segment of Plasmodium falciparum SURFIN(4.1) is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulum.
Published: December, 2012
Abstract: Plasmodium falciparum SURFIN is a type I transmembrane protein that shares domains with molecules expressed on the surface of the red blood cells (RBCs) infected with a variety of malaria parasite species, such as P. falciparum PfEMP1, P. vivax VI...
Read more »
Tags
Antibody
Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells.
Published: December, 2012
Abstract: Adipose-tissue-derived stem cells (ASCs) have received considerable attention due to their easy access, expansion potential, and differentiation capacity. ASCs are believed to have the potential to differentiate into neurons. However, the mechanis...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K27me3 (C15410069)
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System.
Published: December, 2012
Abstract: The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, ...
Read more »
Tags
Antibody
Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
Published: December, 2012
Abstract: Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon sam...
Read more »
Tags
IP-Star Antibody
Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation.
Published: November, 2012
Abstract: Tissue generation and repair requires a stepwise process of cell fate restriction to ensure adult stem cells differentiate in a timely and appropriate manner. A crucial role has been implicated for Polycomb-group (PcG) proteins and the H3K27me3 re...
Read more »
Tags
Bioruptor Chromatin Shearing ChIP-seq Antibody H3K4me3 (C15410003)
Ash2 acts as an Ecdysone Receptor coactivator by stabilizing the histone methyltransferase Trr.
Published: November, 2012
Abstract: The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-...
Read more »
Tags
Antibody

活动

  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
 查看所有活动

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy