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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
Published: April, 2015
Abstract: DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute mye...
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Antibody
A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage.
Published: April, 2015
Abstract: Short- and long-scales intra- and inter-chromosomal interactions are linked to gene transcription, but the molecular events underlying these structures and how they affect cell fate decision during embryonic development are poorly understood. One ...
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Antibody H3K4me3 (C15410003) H3K27me3 (C15410195)
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch.
Published: April, 2015
Abstract: Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but c...
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Antibody
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.
Published: April, 2015
Abstract: Aims: Nasopharyngeal carcinoma (NPC) is a common tumor consistently associated with Epstein-Barr virus infection and prevalent in South China, including Hong Kong, and southeast Asia. Current genomic sequencing studies found only rare mutations in...
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Antibody 5mC (C15200081)
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Published: April, 2015
Abstract: The circadian clock controls the transcription of hundreds of genes through specific chromatin-remodeling events. The histone methyltransferase mixed-lineage leukemia 1 (MLL1) coordinates recruitment of CLOCK-BMAL1 activator complexes to chromatin...
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Antibody
Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.
Published: March, 2015
Abstract: The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes; however, the role of CIITA in gene regulation outside of MHC-II biology is not fully understood. To comprehensively ma...
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Antibody
Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment
Published: March, 2015
Abstract: The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes; however, the role of CIITA in gene regulation outside of MHC-II biology is not fully understood. To comprehensively ma...
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Antibody
Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.
Published: March, 2015
Abstract: CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, th...
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Antibody RARalpha (C15310155)
Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells.
Published: March, 2015
Abstract: Histone modification plays a pivotal role on gene regulation, as regarded as global epigenetic markers, especially in tumor related genes. Hence, chemical approaches targeting histone-modifying enzymes have emerged onto the main stage of anticance...
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Bioruptor Chromatin Shearing
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.
Published: March, 2015
Abstract: Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes. Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis. We mutagenized a non-metastatic mouse cancer c...
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Antibody CRISPR Cas9 (C15200203)
Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.
Published: March, 2015
Abstract: The mechanisms by which transcription factor haploinsufficiency alters the epigenetic and transcriptional landscape in human cells to cause disease are unknown. Here, we utilized human induced pluripotent stem cell (iPSC)-derived endothelial cells...
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Bioruptor Chromatin Shearing ChIP-seq Antibody Microplex Library Preparation kit
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.
Published: March, 2015
Abstract: To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense system composed of clustered regularly interspaced short palindromic repeats (CRISPRs), together with CRISPR-associated genes (Cas). The CRISPR/Cas9 system dev...
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Antibody CRISPR Cas9 (C15200203)
Genome-wide mapping reveals conservation of promoter DNA methylation following chicken domestication.
Published: March, 2015
Abstract: It is well-known that environment influences DNA methylation, however, the extent of heritable DNA methylation variation following animal domestication remains largely unknown. Using meDIP-chip we mapped the promoter methylomes for 23,316 genes in...
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DNA shearing Bioruptor Antibody
An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.
Published: March, 2015
Abstract: The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene modification have been lacking, especially for deletion of essential genes. Here, we describe a ...
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Antibody CRISPR Cas9 (C15200203)
An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo
Published: March, 2015
Abstract: The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene modification have been lacking, especially for deletion of essential genes. Here, we describe a ...
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Antibody CRISPR Cas9 (C15200203)
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.
Published: February, 2015
Abstract: Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of epigenetic mechanisms in this process, focusing on Ewing sarco...
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Antibody H3K4me3 (C15410003) H3K27me3 (C15410195)
MCPH1 maintains long-term epigenetic silencing of ANGPT2 in chronic lymphocytic leukemia.
Published: February, 2015
Abstract: The microcephalin gene (MCPH1) [also known as inhibitor of human telomerase reverse transcriptase (hTERT) expression] is a tumor suppressor gene that is functionally involved in the DNA damage response. Angiopoietin 2 (ANGPT2) is a crucial factor ...
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Bioruptor Chromatin Shearing Antibody
A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.
Published: February, 2015
Abstract: The p53 family and its cofactors are potent inducers of apoptosis and form a barrier to cancer. Here, we investigated the impact of the supposedly inhibitory member of the apoptosis-stimulating protein of p53, iASPP, on the activity of the p53 hom...
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Antibody
The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.
Published: February, 2015
Abstract: The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-...
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Bioruptor Chromatin Shearing ChIP-seq Antibody H3K27ac (C15410174)
Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes
Published: February, 2015
Abstract: Whether nucleic acids that circulate in blood have any patho-physiological functions in the host have not been explored.We report here that far from being inert molecules, circulating nucleic acids have significant biological activities of their o...
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DNA shearing Bioruptor
Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
Published: February, 2015
Abstract: Ten eleven translocation (Tet) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC can be further excised by thymine-DNA glycosylase (Tdg). Here, we present...
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DNA shearing Bioruptor Chromatin Shearing ChIP-seq Antibody
Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.
Published: February, 2015
Abstract: Genome-wide distribution of histone H3K18 and H3K27 acetyltransferases, CBP (CREBBP) and p300 (EP300), is used to map enhancers and promoters, but whether these elements functionally require CBP/p300 remains largely uncertain. Here we compared glo...
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Antibody
Stable X Chromosome Reactivation in Female Human Induced Pluripotent Stem Cells.
Published: January, 2015
Abstract: In placental mammals, balanced expression of X-linked genes is accomplished by X chromosome inactivation (XCI) in female cells. In humans, random XCI is initiated early during embryonic development. To investigate whether reprogramming of female h...
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Antibody
Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo
Published: January, 2015
Abstract: Background Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have been proposed as potential new therapies for lymphoid malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma for ...
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Bioruptor Cell Lysis Western Blot
Embryonic stem cell differentiation requires full length Chd1.
Published: January, 2015
Abstract: The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and pluripotency in embryonic stem cells (ESCs). Here we have studied the ef...
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Antibody H3K4me3 (C15410003)
Genome-wide DNA methylation analysis in Graves' disease.
Published: January, 2015
Abstract: As an autoimmune disease, Graves' disease (GD) is associated with many genetic and environmental risk factors. Although the exact mechanism remains unclear, epigenetic determinants, such as DNA methylation, are thought to contribute to the pathoge...
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DNA shearing Bioruptor Antibody
An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations.
Published: January, 2015
Abstract: Combined chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) has enabled genome-wide epigenetic profiling of numerous cell lines and tissue types. A major limitation of ChIP-seq, however, is the large number of cells required t...
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Bioruptor Antibody H3K27me3 (C15410069)
Ultra-low-input native ChIP-seq for rare cell populations
Published: January, 2015
Abstract: Combined chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) has enabled genome-wide epigenetic profiling of numerous cell lines and tissue types. A major limitation of ChIP-seq, however, is the large number of cells required t...
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Antibody H3K27me3 (C15410069)
A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus.
Published: January, 2015
Abstract: Non-coding RNAs (ncRNAs) play major roles in proper chromatin organization and function. Senescence, a strong anti-proliferative process and a major anticancer barrier, is associated with dramatic chromatin reorganization in heterochromatin foci. ...
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Antibody H3K4me3 (C15410003)
The Integrase Cofactor LEDGF/p75 Associates with Iws1 and Spt6 for Postintegration Silencing of HIV-1 Gene Expression in Latently Infected Cells.
Published: January, 2015
Abstract: The persistence of a latent reservoir containing transcriptionally silent, but replication-competent, integrated provirus is a serious challenge to HIV eradication. HIV integration is under the control of LEDGF/p75, the cellular cofactor of viral ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

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  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
  • 2nd Clinical Genomic Biomarkers Summit
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    Jun 24, 2025
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