Megaruptor 3 Shearing Kit

Non-disruptive in vitro monitoring of cellular states with cell-free DNA methylation
Hess, Anja et al.
Individual CpG methylation signatures characterize each mammalian cell type, thereby offering a powerful readout for clinical and diagnostic applications. Here, we apply this principle to in vitro cellular systems, using cell-free DNA released into the culture medium to track epigenomic responses to small-molecule t...

Higher order repeat structures reflect diverging evolutionary paths in maize centromeres and knobs
Piri, Rebecca D et al.
Background: Highly repetitive tandem repeat arrays, known as satellite DNAs, are enriched in low-recombination regions such as centromeres. Satellite arrays often contain complex internal structures called higher-order repeats (HORs), which may have functional significance. Maize is unusual in that its satellit...

Single chromatin fiber profiling and nucleosome position mapping in the human brain
Peter, Cyril J. et al.
Motivation Nucleosomes are the basic unit of chromatin, but genome-scale maps of nucleosome positioning along chromatin fibers do not exist for brain and many other complex tissues. Conventional chromatin accessibility assays designed to map nucleosome-depleted regions via nucleolytic digestion face major limitat...