Infinium Mouse Methylation Array Service

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Description
End-to-end array

Bisulfite conversion

Whole genome amplification

Array hybridization

Single base extension

Array scanner

Analysis	Features
Standard	Standard files provided: Sample annotation Variable annotation Scanner output (IDAT files)
Differential methylation analysis	Identification of differentially methylated CpGs between sample groups. Files provided: Report with summary of differential methylation analysis and plots File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea) File containing differential methylated regions (DMRs)
Gene ontology terms analysis	Enrichment analysis on gene sets. Gene Ontology terms that are overrepresented in differentially bound regions may indicate the underlying biological processes involved.
Pathway analysis	Identify biochemical pathways in which genes associated with differentially methylated regions (or individual differentially methylated CpGs) may be overrepresented.

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			'description' => '<p>Infinium MethylationEPIC＆Hydroxymethylation oxEPIC アレイは、選択的な酸化、バイサルファイト処理とIllumina&reg;技術に基づくゲノムワイドのDNAメチル化解析技術です。これは、一塩基分解能を有するゲノム全体にわたる850,000を超えるヒトCpG位置のメチル化レベル(5mC)と総メチル化（5mC + 5hmC）レベルの定量的な検出を可能にします。</p>
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<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
<li><span style="font-family: inherit;">5mCと5hmCの判別</span></li>
<li><span style="font-family: inherit; text-align: justify;">Differentially methylated とhydroxymethylated site解析</span></li>
<li><span style="font-family: inherit; text-align: justify;">エンドツーエンドの酸化変換、バイサルファイト変換、アレイハイブリダイゼーション、解析を含む包括的なサービス</span></li>
</ul>
<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<li style="font-weight: 400;">Whole genome amplification</li>
<li style="font-weight: 400;"><span style="font-weight: 400;">Array hybridization</span></li>
<li style="font-weight: 400;"><span style="font-weight: 400;">Single base extension &nbsp;</span></li>
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<p><strong>Standard</strong></p>
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<td style="width: 70%;">
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<li>Sample annotation</li>
<li>Variable annotation</li>
<li>Scanner output&nbsp;(IDAT files)</li>
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</td>
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<p><strong>Differential methylation analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Identification of differentially methylated CpGs between sample groups.</p>
<p><em>Files provided:</em></p>
<ul>
<li>Report with summary of differential methylation analysis and plots</li>
<li>File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea)</li>
<li>File containing differential methylated regions (DMRs)</li>
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<td style="vertical-align: top;">
<p><strong>Gene ontology terms analysis</strong></p>
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<td style="width: 70%;">
<p>Enrichment analysis on gene sets. Gene Ontology terms that are overrepresented in differentially bound regions may indicate the underlying biological processes involved.</p>
</td>
</tr>
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<td style="vertical-align: top;">
<p><strong>Pathway analysis</strong></p>
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<p>バイサルファイト変換で、2種の5-メチルシトシンと5-ヒドロキシメチルシトシンのが判別なくシトシンとして読み取られ、DNAサンプルの総メチル化（5mC + 5hmC）レベルのマップが検出されます。 最初に酸化ステップを行うことで、5-ヒドロキシメチルシトシンは5-ホルミルシトシンに変換され、その後、バイサルファイト処理中にウラシルに変換されます。 その結果、5メチルシトシンのみがシトシンとして読み取られ、DNAサンプルのメチル化（5mC）レベルのマップが検出されます。 この2つの方法を組み合わせると、DNAサンプルの5-ヒドロキシメチルシトシン（5hmC）の状態を調べることが可能です。</p>
<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
<li><span style="font-family: inherit;">5mCと5hmCの判別</span></li>
<li><span style="font-family: inherit; text-align: justify;">Differentially methylated とhydroxymethylated site解析</span></li>
<li><span style="font-family: inherit; text-align: justify;">エンドツーエンドの酸化変換、バイサルファイト変換、アレイハイブリダイゼーション、解析を含む包括的なサービス</span></li>
</ul>
<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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</td>
<td>
<ul>
<li style="font-weight: 400;">Bisulfite conversion</li>
<li style="font-weight: 400;">Whole genome amplification</li>
<li style="font-weight: 400;"><span style="font-weight: 400;">Array hybridization</span></li>
<li style="font-weight: 400;"><span style="font-weight: 400;">Single base extension &nbsp;</span></li>
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</td>
</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Standard</strong></p>
</td>
<td style="width: 70%;">
<p><em>Standard files provided:</em></p>
<ul>
<li>Sample annotation</li>
<li>Variable annotation</li>
<li>Scanner output&nbsp;(IDAT files)</li>
</ul>
</td>
</tr>
<tr>
<td style="vertical-align: top; width=30%; text-align: left;">
<p><strong>Differential methylation analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Identification of differentially methylated CpGs between sample groups.</p>
<p><em>Files provided:</em></p>
<ul>
<li>Report with summary of differential methylation analysis and plots</li>
<li>File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea)</li>
<li>File containing differential methylated regions (DMRs)</li>
</ul>
</td>
</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Gene ontology terms analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Enrichment analysis on gene sets. Gene Ontology terms that are overrepresented in differentially bound regions may indicate the underlying biological processes involved.</p>
</td>
</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Pathway analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Identify biochemical pathways in which genes associated with differentially methylated regions (or individual differentially methylated CpGs) may be overrepresented.</p>
</td>
</tr>
</tbody>
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			'description' => '<div class="row">
<div class="small-12 medium-10 large-10 columns text-left">
<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
</div>
<div class="small-12 medium-2 large-2 columns text-left"><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></div>
</div>
<center><img alt="DNA-RNA-Chromatin-Diagenode" src="https://www.diagenode.com/img/categories/services/chromatin-dna-rna.png" /></center>
<div class="row">
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #099f92;">
<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
<li>ChIP-seq analysis Histone modification</li>
<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
<ul>
<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
</ul>
<div class="extra-spaced">
<ul class="small-block-grid-2 medium-block-grid-3 large-block-grid-3">
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
</li>
</ul>
</div>
<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
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<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>
<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
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<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 285,000&nbsp;markers detected in&nbsp;mouse samples at single nucleotide resolution</li>
<li>Suitable for common laboratory mouse strains</li>
<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
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<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
<ul>
<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
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<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
<li><span>Allowing deep sequencing at high coverage levels for rare variant identification</span></li>
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<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
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<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
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<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
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<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
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<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<li>Report with summary of differential methylation analysis and plots</li>
<li>File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea)</li>
<li>File containing differential methylated regions (DMRs)</li>
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</td>
</tr>
<tr>
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<p><strong>Gene ontology terms analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Enrichment analysis on gene sets. Gene Ontology terms that are overrepresented in differentially bound regions may indicate the underlying biological processes involved.</p>
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</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Pathway analysis</strong></p>
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<p>Identify biochemical pathways in which genes associated with differentially methylated regions (or individual differentially methylated CpGs) may be overrepresented.</p>
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<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<center><img alt="DNA-RNA-Chromatin-Diagenode" src="https://www.diagenode.com/img/categories/services/chromatin-dna-rna.png" /></center>
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<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
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<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
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<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
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<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
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<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
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<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
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<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
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<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
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<div class="extra-spaced">
<ul class="small-block-grid-2 medium-block-grid-3 large-block-grid-3">
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
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<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
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<li>Dedicated <strong>in-house expert</strong> for your project</li>
<li><strong>Integrative</strong> data analysis</li>
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<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
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<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
<ul>
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<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
<ul>
<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
<ul>
<li>Focus on D<span>NA methylation patterning of selective regions with single nucleotide resolution</span></li>
<li><span>Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture</span></li>
<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
<li><span>Allowing deep sequencing at high coverage levels for rare variant identification</span></li>
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<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
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<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
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			'description' => '<p>Infinium MethylationEPIC＆Hydroxymethylation oxEPIC アレイは、選択的な酸化、バイサルファイト処理とIllumina&reg;技術に基づくゲノムワイドのDNAメチル化解析技術です。これは、一塩基分解能を有するゲノム全体にわたる850,000を超えるヒトCpG位置のメチル化レベル(5mC)と総メチル化（5mC + 5hmC）レベルの定量的な検出を可能にします。</p>
<p>バイサルファイト変換で、2種の5-メチルシトシンと5-ヒドロキシメチルシトシンのが判別なくシトシンとして読み取られ、DNAサンプルの総メチル化（5mC + 5hmC）レベルのマップが検出されます。 最初に酸化ステップを行うことで、5-ヒドロキシメチルシトシンは5-ホルミルシトシンに変換され、その後、バイサルファイト処理中にウラシルに変換されます。 その結果、5メチルシトシンのみがシトシンとして読み取られ、DNAサンプルのメチル化（5mC）レベルのマップが検出されます。 この2つの方法を組み合わせると、DNAサンプルの5-ヒドロキシメチルシトシン（5hmC）の状態を調べることが可能です。</p>
<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
<li><span style="font-family: inherit;">5mCと5hmCの判別</span></li>
<li><span style="font-family: inherit; text-align: justify;">Differentially methylated とhydroxymethylated site解析</span></li>
<li><span style="font-family: inherit; text-align: justify;">エンドツーエンドの酸化変換、バイサルファイト変換、アレイハイブリダイゼーション、解析を含む包括的なサービス</span></li>
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<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<li>Variable annotation</li>
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<p><strong>Differential methylation analysis</strong></p>
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<p>Identification of differentially methylated CpGs between sample groups.</p>
<p><em>Files provided:</em></p>
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<li>Report with summary of differential methylation analysis and plots</li>
<li>File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea)</li>
<li>File containing differential methylated regions (DMRs)</li>
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</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Gene ontology terms analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Enrichment analysis on gene sets. Gene Ontology terms that are overrepresented in differentially bound regions may indicate the underlying biological processes involved.</p>
</td>
</tr>
<tr>
<td style="vertical-align: top;">
<p><strong>Pathway analysis</strong></p>
</td>
<td style="width: 70%;">
<p>Identify biochemical pathways in which genes associated with differentially methylated regions (or individual differentially methylated CpGs) may be overrepresented.</p>
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		'description' => '<p>Infinium MethylationEPIC＆Hydroxymethylation oxEPIC アレイは、選択的な酸化、バイサルファイト処理とIllumina&reg;技術に基づくゲノムワイドのDNAメチル化解析技術です。これは、一塩基分解能を有するゲノム全体にわたる850,000を超えるヒトCpG位置のメチル化レベル(5mC)と総メチル化（5mC + 5hmC）レベルの定量的な検出を可能にします。</p>
<p>バイサルファイト変換で、2種の5-メチルシトシンと5-ヒドロキシメチルシトシンのが判別なくシトシンとして読み取られ、DNAサンプルの総メチル化（5mC + 5hmC）レベルのマップが検出されます。 最初に酸化ステップを行うことで、5-ヒドロキシメチルシトシンは5-ホルミルシトシンに変換され、その後、バイサルファイト処理中にウラシルに変換されます。 その結果、5メチルシトシンのみがシトシンとして読み取られ、DNAサンプルのメチル化（5mC）レベルのマップが検出されます。 この2つの方法を組み合わせると、DNAサンプルの5-ヒドロキシメチルシトシン（5hmC）の状態を調べることが可能です。</p>
<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
<li><span style="font-family: inherit;">5mCと5hmCの判別</span></li>
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<li><span style="font-family: inherit; text-align: justify;">エンドツーエンドの酸化変換、バイサルファイト変換、アレイハイブリダイゼーション、解析を含む包括的なサービス</span></li>
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<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<p><strong>Standard</strong></p>
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</td>
</tr>
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<p><strong>Differential methylation analysis</strong></p>
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<div class="small-12 medium-10 large-10 columns text-left">
<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<div class="small-12 medium-2 large-2 columns text-left"><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></div>
</div>
<center><img alt="DNA-RNA-Chromatin-Diagenode" src="https://www.diagenode.com/img/categories/services/chromatin-dna-rna.png" /></center>
<div class="row">
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #099f92;">
<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
<li>ChIP-seq analysis Histone modification</li>
<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
<ul>
<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
</ul>
<div class="extra-spaced">
<ul class="small-block-grid-2 medium-block-grid-3 large-block-grid-3">
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
</li>
</ul>
</div>
<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
<li><strong>Integrative</strong> data analysis</li>
<li>Presentation-<strong>quality data</strong> and graphs</li>
</ul>
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<div class="small-12 medium-4 large-4 columns">
<div class="panel"><center><img src="http://www.diagenode.com/img/categories/services/dna-workflow.png" alt="DNA-methylation -Diagenode" /></center>
<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns">
<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>
<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 285,000&nbsp;markers detected in&nbsp;mouse samples at single nucleotide resolution</li>
<li>Suitable for common laboratory mouse strains</li>
<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>-->
<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
<ul>
<li>Robust and cost-effective solution with&nbsp;reliable results</li>
<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
</ul>
<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
<ul>
<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
</ul>
<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
<ul>
<li>Focus on D<span>NA methylation patterning of selective regions with single nucleotide resolution</span></li>
<li><span>Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture</span></li>
<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
<li><span>Allowing deep sequencing at high coverage levels for rare variant identification</span></li>
</ul>
<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
<ul>
<li>Immunoprecipitation assay (antibody-based approach) to study 5-mC genome-wide</li>
<li>Resolution of 100-500 bp</li>
</ul>-->
<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
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<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
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<p><span><i class="fa fa-arrow-circle-right"></i> </span><a href="https://www.diagenode.com/jp/categories/dna-methylation-profiling-services">Reduced Representation、全ゲノム、およびターゲット解析に関して、詳しくはその他のDNAメチル化プロファイリングサービスをご覧ください。</a></p>
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<h2>ゲノムワイドの包括的なカバレッジに最適な優れた方法</h2>
<ul class="square">
<li>所要時間の短縮、高いコストパフォーマンス</li>
<li>単一ヌクレオチド分解能で850,000を超えるヒトCpG位置</li>
<li><span style="font-family: inherit;">CpG、非CpG、およびCHH部位のメチル化部位の定量分析</span></li>
<li><span style="font-family: inherit;">5mCと5hmCの判別</span></li>
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<li style="font-weight: 400;">Whole genome amplification</li>
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<li style="font-weight: 400;"><span style="font-weight: 400;">Single base extension &nbsp;</span></li>
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<p><em>Files provided:</em></p>
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<li>File containing the differentially methylated CpGs and breakdown of those positions in regional analysis (CpG islands, shelves, shores and open sea)</li>
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<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
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<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
</div>
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<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
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<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
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<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
<ul>
<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
</ul>
<div class="extra-spaced">
<ul class="small-block-grid-2 medium-block-grid-3 large-block-grid-3">
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
</li>
</ul>
</div>
<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
<li><strong>Integrative</strong> data analysis</li>
<li>Presentation-<strong>quality data</strong> and graphs</li>
</ul>
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<div class="panel"><center><img src="http://www.diagenode.com/img/categories/services/dna-workflow.png" alt="DNA-methylation -Diagenode" /></center>
<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>
<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 285,000&nbsp;markers detected in&nbsp;mouse samples at single nucleotide resolution</li>
<li>Suitable for common laboratory mouse strains</li>
<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>-->
<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
<ul>
<li>Robust and cost-effective solution with&nbsp;reliable results</li>
<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
</ul>
<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
<ul>
<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
</ul>
<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
<ul>
<li>Focus on D<span>NA methylation patterning of selective regions with single nucleotide resolution</span></li>
<li><span>Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture</span></li>
<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
<li><span>Allowing deep sequencing at high coverage levels for rare variant identification</span></li>
</ul>
<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
<ul>
<li>Immunoprecipitation assay (antibody-based approach) to study 5-mC genome-wide</li>
<li>Resolution of 100-500 bp</li>
</ul>-->
<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
</ul>
</div>
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