The DNA methylation control package V2 includes one methylated and one unmethylated spike-in controls that can be added directly to the DNA sample of interest before any methylation profiling experiment (e.g. with Diagenode's Premium RRBS Kit or MagMeDIP qPCR Kit).
Those spike-in controls have been produced using synthetic oligonucleotides and are not homologous to any model species. Therefore, they will not interfere with the DNA sample of interest.
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