Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×

Experimental Study on Malignant Transformation of Human Bronchial Epithelial Cells Induced by Glycidyl Methacrylate and Analysis on its Methylation

Abstract: Objective To establish the model of human bronchial epithelial cells(16HBE) malignant transformation induced by glycidyl methacrylate(GMA) and define the different methylation genes at different stages. Methods DNA was extracted at different 16...
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DNA shearing Bioruptor Antibody

Detection of DNA methylation by MeDIP and MBDCap assays: an overview of techniques.

Abstract: DNA methylation has been characterized as the representative example of epigenetic modifications and implicated in numerous biological processes, such as genomic imprinting and X chromosome inactivation. It primarily occurs at CpG dinucleotides in...
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DNA shearing Bioruptor Antibody

Epigenetic-Mediated Downregulation of μ-Protocadherin in Colorectal Tumours

Abstract: Carcinogenesis involves altered cellular interaction and tissue morphology that partly arise from aberrant expression of cadherins. Mucin-like protocadherin is implicated in intercellular adhesion and its expression was found decreased in colorect...
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Bioruptor Chromatin Shearing Antibody H3K4me3 (C15410003) Bioruptor Plus

Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA

Abstract: One of the most frequent genetic aberrations in acute myeloid leukemia (AML) is chromosomal translocation between AML1/RUNX1 on chromosome 21 and ETO gene on chromosome 8 resulting in the expression of chimeric oncogene AML1-ETO. Although patients...
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Antibody

A self-inactivating system for AAV-mediated in vivo base editing

Abstract: DNA base editors have been harnessed as an exciting therapeutic platform for human diseases and are rapidly progressing into human clinical trials. However, persistent expression of base editors delivered via adeno-associated virus (AAV) poses con...
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Antibody CRISPR

BET protein inhibition sensitizes glioblastoma cells to temozolomidetreatment by attenuating MGMT expression

Abstract: Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small mole...
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Bioruptor Antibody iDeal ChIP-seq Kit for Transcription Factors

PRAME induces genomic instability in uveal melanoma

Abstract: PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in sperm...
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Antibody

Nucleophosmin 1 cooperates with the methyltransferase DOT1L toregulate H3K79me2 levels and DNA satellites expression atperi-nucleolar heterochromatin

Abstract: The histone methyltransferase DOT1L catalyzes methylation of H3K79 and it is highly conserved in mammals. DOT1L plays a functional role in several biological processes including cell cycle regulation, DNA repair, RNA splicing and gene expression, ...
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Bioruptor Antibody

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