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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.
Published: January, 2015
Abstract: Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to treatment. Emerging evidence has suggested that fluctuations in ER co-regulatory pro...
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IP-Star Antibody IP-Star Compact
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.
Published: January, 2015
Abstract: TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruse...
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Antibody
iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data.
Published: January, 2015
Abstract: RNA-seq is a sensitive and accurate technique to compare steady-state levels of RNA between different cellular states. However, as it does not provide an account of transcriptional activity per se, other technologies are needed to more precisely d...
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Antibody
BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.
Published: January, 2015
Abstract: Prostate cancer is driven by a combination of genetic and/or epigenetic alterations. Epigenetic alterations are frequently observed in all human cancers, yet how aberrant epigenetic signatures are established is poorly understood. Here we show tha...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
CpG signalling, H2A.Z/H3 acetylation and microRNA-mediated deferred self-attenuation orchestrate foetal NOS3 expression.
Published: January, 2015
Abstract: BACKGROUND: An adverse intrauterine environment leads to permanent physiological changes including vascular tone regulation, potentially influencing the risk for adult vascular diseases. We therefore aimed to monitor responsive NOS3 expression in ...
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DNA shearing Bioruptor Chromatin Shearing Antibody 5mC (C15200081)
Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells
Published: December, 2014
Abstract: Abstract Background Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especi ally at the pericentromeric region. HP1 might participate in recruiting and directing Mis12...
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Antibody
Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control.
Published: December, 2014
Abstract: Resistance to paclitaxel chemotherapy frequently develops in ovarian cancer. Oncolytic adenoviruses are a novel therapy for human malignancies that are being evaluated in early phase trials. However, there are no reliable predictive biomarkers for...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
Identification of SCAN Domain Zinc-Finger Gene ZNF449 as a Novel Factor of Chondrogenesis.
Published: December, 2014
Abstract: Transcription factors SOX9, SOX5 and SOX6 are indispensable for generation and differentiation of chondrocytes. However, molecular mechanisms to induce the SOX genes are poorly understood. To address this issue, we previously determined the human ...
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Antibody
Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells
Published: December, 2014
Abstract: The intestinal epithelium is a particularly attractive biological adult model to study epigenetic mechanisms driving adult stem cell renewal and cell differentiation. Since epigenetic modifications are dynamic, we have developed an original ex viv...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003) IPure kit True MicroChIP kit
ChIPping Away at the Drosophila Clock
Published: December, 2014
Abstract: In eukaryotes, the circadian clock controls 24 h rhythms in physiology, metabolism, and behavior via cell autonomous transcriptional feedback loops. These feedback loops keep circadian time and control rhythmic outputs by driving rhythms in transc...
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Bioruptor Chromatin Shearing ChIP-qPCR
Cold acclimation induces distinctive changes in the chromatin state and transcript levels of COR genes in Cannabis sativa varieties with contrasting cold acclimation capacities.
Published: December, 2014
Abstract: Little is known about the capacity of Cannabis sativa to cold acclimate and develop freezing tolerance. This study investigates the cold acclimation capacity of nine C. sativa varieties and the underlying genetic and epigenetic responses. The vari...
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DNA shearing Bioruptor Chromatin Shearing ChIP-qPCR Antibody
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.
Published: December, 2014
Abstract: DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-seq) in whole-blood-derived DNA from 27 ...
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Antibody
A Distal Locus Element Mediates IFN-γ Priming of Lipopolysaccharide-Stimulated TNF Gene Expression.
Published: December, 2014
Abstract: Interferon γ (IFN-γ) priming sensitizes monocytes and macrophages to lipopolysaccharide (LPS) stimulation, resulting in augmented expression of a set of genes including TNF. Here, we demonstrate that IFN-γ priming of LPS-stimulated TNF transcripti...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs.
Published: December, 2014
Abstract: The open chromatin of embryonic stem cells (ESCs) condenses into repressive heterochromatin as cells exit the pluripotent state. How the 3D genome organization is orchestrated and implicated in pluripotency and lineage specification is not underst...
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Antibody
Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation.
Published: December, 2014
Abstract: Artificial transcription factors (ATFs) and genomic nucleases based on a DNA binding platform consisting of multiple zinc finger domains are currently being developed for clinical applications. However, no genome-wide investigations into their bin...
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Antibody
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Published: December, 2014
Abstract: 5-hydroxymethylcytosine (5hmC) has been suggested to be involved in various nucleic acid transactions and cellular processes, including transcriptional regulation, demethylation of 5-methylcytosine and stem cell pluripotency. We have identified an...
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Antibody H3pan (C15310135)
Hypermethylation of cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.
Published: December, 2014
Abstract: High-fat diet (HFD) is an environmental factor that contributes to the pathogenesis of obesity and type 2 diabetes. A number of genes influencing oxidative phosphorylation (OXPHOS) were found to be downregulated in skeletal muscle of humans and ra...
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Antibody
Acute Depletion Redefines the Division of Labor among DNA Methyltransferases in Methylating the Human Genome.
Published: November, 2014
Abstract: Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DN...
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Antibody 5mC (C15200081)
Genome-wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats.
Published: November, 2014
Abstract: OBJECTIVE: To identify aberrantly methylated candidate genes that are involved in the development of polycystic ovary syndrome (PCOS). DESIGN: Animal model. SETTING: University-affiliated laboratory. ANIMAL(S): Sprague-Dawley rats. INTERVENTION(S)...
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DNA shearing Bioruptor Antibody
A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxmethylcytosine levels
Published: October, 2014
Abstract: The mechanisms by which viruses modulate the immune system include changes in host genomic methylation. 5-hydroxmethylcytosine (5hmC) is the catalytic product of the Tet (Ten-11 translocation) family of enzymes and may serve as an intermediate of ...
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Antibody 5mC (C15200081)
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.
Published: October, 2014
Abstract: The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen rec...
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Antibody
Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs.
Published: October, 2014
Abstract: Most complex disease-associated genetic variants are located in non-coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct ...
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Antibody H3K4me3 (C15410003)
A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Published: October, 2014
Abstract: The p53 transcription factor plays an important role in genome integrity. To perform this task, p53 regulates the transcription of genes promoting various cellular outcomes including cell cycle arrest, apoptosis or senescence. The precise regulati...
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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus
MeDIP-on-Chip for Methylation Profiling
Published: October, 2014
Abstract: DNA methylation is an important regulatory step in gene expression. Knowledge of the alterations in DNA methylation at a whole genome scale improves our understanding of gene regulation and potential correlations with biological events or disease ...
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DNA shearing Bioruptor
White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion.
Published: October, 2014
Abstract: White matter abnormalities due to age-related cerebrovascular alterations is a common pathological hallmark associated with functional impairment in the elderly which has been modeled in chronically hypoperfused mice. 5-Methylcytosine (5mC) and it...
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Antibody
Obesity increases histone H3 lysine 9 and 18 acetylation at Tnfa and Ccl2 genes in mouse liver
Published: October, 2014
Abstract: Obesity contributes to the development of non‑alcoholic fatty liver disease (NAFLD), which is characterized by the upregulated expression of two key inflammatory mediators: tumor necrosis factor (Tnfa) and monocyte chemotactic protein 1 (Mcp1; als...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003) Bioruptor Plus
Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote.
Published: October, 2014
Abstract: The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential. Previous studies have suggested that the patern...
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Antibody
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.
Published: October, 2014
Abstract: The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also induces non-specific beneficial effects against certain forms of malig...
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Antibody
The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity.
Published: October, 2014
Abstract: Histone variant H3.3 is deposited in chromatin at active sites, telomeres, and pericentric heterochromatin by distinct chaperones, but the mechanisms of regulation and coordination of chaperone-mediated H3.3 loading remain largely unknown. We show...
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Bioruptor Chromatin Shearing Antibody
The specific alteration of histone methylation profiles by DZNep during early zebrafish development.
Published: September, 2014
Abstract: Early embryo development constitutes a unique opportunity to study acquisition of epigenetic marks, including histone methylation. This study investigates the in vivo function and specificity of 3-deazaneplanocin A (DZNep), a promising anti-cancer...
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Antibody

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