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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1478 publications found×
Immunohistochemical Detection of Oxidized Forms of 5-Methylcytosine in Embryonic and Adult Brain Tissue
Published: September, 2015
Abstract: DNA methylation (5-methylcytosine, 5mC) is a major epigenetic modification of the eukaryotic genome associated with gene repression. Ten-eleven translocation proteins (Tet1/2/3) can oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (...
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Antibody 5mC (C15200081)
Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes
Published: September, 2015
Abstract: The transcription factor p63 is a key regulator in epidermal keratinocyte proliferation and differentiation. However, the role of p63 in gene regulation during these processes is not well understood. To investigate this, we recently generated geno...
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Antibody
Chromatin assembly factor CAF-1 represses priming of plant defence response genes
Published: September, 2015
Abstract: Plants have evolved efficient defence systems against pathogens that often rely on specific transcriptional responses. Priming is part of the defence syndrome, by establishing a hypersensitive state of defence genes such as after a first encounter...
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Antibody
The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection
Published: August, 2015
Abstract: BACKGROUND: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It...
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Antibody
Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells.
Published: August, 2015
Abstract: Recruitment of transcription machinery to target promoters for aberrant gene expression has been well studied, but underlying control directed by distant-acting enhancers remains unclear in cancer development. Our previous study demonstrated that ...
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Antibody
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection.
Published: August, 2015
Abstract: CRISPR-Cas9 systems provide a platform for high efficiency genome editing that are enabling innovative applications of mammalian cell engineering. However, the delivery of Cas9 and synthesis of guide RNA (gRNA) remain as steps that can limit overa...
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Antibody CRISPR Cas9 (C15200203)
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
Published: August, 2015
Abstract: The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome duplication processes. Polycomb activities during DNA replication and DNA damage repair are unclear, particularly without in...
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Antibody
C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis
Published: August, 2015
Abstract: Highlights C/EBPα activates two classes of prospective myeloid enhancers in B cells Pre-existing enhancers are bound by PU.1 and become hyper-activated by C/EBPα C/EBPα acts as a pioneer factor with delayed kinetics on...
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Antibody
Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
Published: August, 2015
Abstract: The TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain, and results lack in vivo models. Here...
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Antibody
Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation
Published: July, 2015
Abstract: Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for faithful segregation of genetic material to daughter cells. Here we show that condensin, which is essential for assembling condensed chromosomes, helps to pre...
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Antibody
Non-coding recurrent mutations in chronic lymphocytic leukaemia.
Published: July, 2015
Abstract: Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases ...
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Antibody
Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes
Published: July, 2015
Abstract: The product of the Plasmodium falciparum genes clag3.1 and clag3.2 plays a fundamental role in malaria parasite biology by determining solute transport into infected erythrocytes. Expression of the two clag3 genes is mutually exclusive, such that ...
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Antibody
The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution.
Published: July, 2015
Abstract: BACKGROUND: Epigenomic studies on humans and model species have revealed substantial inter-individual variation in histone modification profiles. However, the pattern of this variation has not been precisely characterized, particularly regardin...
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Antibody
The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.
Published: July, 2015
Abstract: The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expressio...
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Antibody
DNA methylation directs functional maturation of pancreatic β cells
Published: July, 2015
Abstract: Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect against hypoglycemia. β cells lack this functional capa...
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Antibody
Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation
Published: July, 2015
Abstract: The transcription factor p63 plays a pivotal role in keratinocyte proliferation and differentiation in the epidermis. However, how p63 regulates epidermal genes during differentiation is not yet clear. Using epigenome profiling of differentiating ...
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Antibody
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells
Published: June, 2015
Abstract: Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulators and transcriptional machinery, leading to fin...
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HighCell ChIP kit
Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses.
Published: June, 2015
Abstract: Citrate, a central component of cellular metabolism, is a widely used anti-coagulant due to its ability to chelate calcium. Adenosine triphosphate (ATP)-citrate lyase, which metabolizes citrate, has been shown to be essential for inflammation, but...
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Antibody LowCell ChIP kit H3K9ac (C15200185)
Gene chip analysis of Arabidopsis thaliana genomic DNA methylation and gene expression in response to carbendazim.
Published: June, 2015
Abstract: OBJECTIVES: To examine the effects of carbendazim on Arabidopsis genomic DNA methylation and gene expression. RESULTS: Carbendazim caused widespread changes in gene loci methylation and gene expression. With 0.1 mM (D2) and 0.2 mM (D3) carbendazim...
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DNA shearing Bioruptor Antibody
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage.
Published: June, 2015
Abstract: DNA double-strand breaks (DSBs) are repaired by two main pathways: nonhomologous end-joining and homologous recombination (HR). Repair pathway choice is thought to be determined by cell cycle timing and chromatin context. Nucleoli, prominent nucle...
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Antibody CRISPR Cas9 (C15200203)
Gadd45b and N-methyl-D-aspartate induced DNA demethylation in postmitotic neurons.
Published: June, 2015
Abstract: AIM: In nondividing neurons examine the role of Gadd45b in active 5-methylcytosine (5MC) and 5-hydroxymethylcytosine (5HMC) removal at a gene promoter highly implicated in mental illnesses and cognition, Bdnf. MATERIALS & METHODS: Mouse prima...
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Antibody
Active human nucleolar organizer regions are interspersed with inactive rDNA repeats in normal and tumor cells.
Published: June, 2015
Abstract: AIM: The synthesis of rRNA is a key determinant of normal and malignant cell growth and subject to epigenetic regulation. Yet, the epigenomic features of rDNA arrays clustered in nucleolar organizer regions are largely unknown. We set out to ex...
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Antibody 5mC (C15200081)
Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression
Published: May, 2015
Abstract: BACKGROUND: Selective maintenance of genomic epigenetic imprints during pre-implantation development is required for parental origin-specific expression of imprinted genes. The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary f...
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Antibody
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression.
Published: May, 2015
Abstract: The histone variant macroH2A (mH2A) has been implicated in transcriptional repression, but the molecular mechanisms that contribute to global mH2A-dependent genome regulation remain elusive. Using chromatin immunoprecipitation sequencing (ChIP-seq...
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Antibody
The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues.
Published: May, 2015
Abstract: CRNDE, recently described as the lncRNA-coding gene, is overexpressed at RNA level in human malignancies. Its role in gametogenesis, cellular differentiation and pluripotency has been suggested as well. Herein, we aimed to verify our hypothesis th...
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Bioruptor Cell Lysis
Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency.
Published: May, 2015
Abstract: Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and activin/nodal signalling is required to sustain self-renewal of human PSCs ...
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Antibody H3K4me3 (C15410003) 5mC (C15200081) H3K27me3 (C15410195)
Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape.
Published: May, 2015
Abstract: Human pluripotent stem cells (hPSCs) display extensive epigenetic instability, particularly on the X chromosome. In this study, we show that, in hPSCs, the inactive X chromosome has a specific heterochromatin landscape that predisposes it to erosi...
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Antibody
Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.
Published: May, 2015
Abstract: The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79...
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Antibody
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.
Published: May, 2015
Abstract: Alternative pre-mRNA splicing is a highly cell type-specific process essential to generating protein diversity. However, the mechanisms responsible for the establishment and maintenance of heritable cell-specific alternative-splicing programs are ...
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Bioruptor Chromatin Shearing Antibody H3K27me3 (C15410195)
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Published: May, 2015
Abstract: DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Here we inactivated all three catalytically active DNA methyltransferases (DNMTs) in human embryonic stem cells (ESCs) using...
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Antibody 5mC (C15200081)

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