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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase.
Published: February, 2016
Abstract: BACKGROUND: DNA methylation is one way to encode epigenetic information and plays a crucial role in regulating gene expression during embryonic development. DNA methylation marks are established by the DNA methyltransferases and, recently, a me...
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Antibody
Chemical Biology Approaches for Characterization of Epigenetic Regulators
Published: February, 2016
Abstract: Chemical biology approaches are a powerful means to functionally characterize epigenetic regulators such as histone modifying enzymes. We outline experimental protocols and best practices for the cellular characterization and use of “chemica...
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Antibody
Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development.
Published: February, 2016
Abstract: Although it is believed that mammalian sperm carry small noncoding RNAs (sncRNAs) into oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly have any function during fertilization and preimplantation embryonic de...
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Antibody
The JMJD3 Histone Demethylase and the EZH2 Histone Methyltransferase in Prostate Cancer
Published: February, 2016
Abstract: Prostate cancer is themost common cancer in men. It has been clearly established that genetic and epigenetic alterations of histone 3 lysine 27 trimethylation (H3K27me3) are common events in prostate cancer. This mark is deregulated in prostate ca...
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Antibody
Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model
Published: February, 2016
Abstract: Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable c...
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Antibody
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
Published: February, 2016
Abstract: The MOZ-TIF2 translocation, that fuses MOZ (Monocytic Leukemia Zinc finger protein) histone acetyltransferase (HAT) with the nuclear co-activator TIF2, is associated the development of Acute Myeloid Leukemia. We recently showed that in t...
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Antibody
The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms
Published: February, 2016
Abstract: Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported in cancer. Epigenetic si...
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Antibody
Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors
Published: February, 2016
Abstract: BACKGROUND: The contribution of epigenetic factors, such as histone acetylation and DNA methylation, to the regulation of alcohol-drinking behavior has been increasingly recognized over the last several years. GADD45b is a protein demonstrated to...
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Antibody 5mC (C15200081)
Protocol for Methylated DNA Immunoprecipitation (MeDIP) Analysis
Published: February, 2016
Abstract: DNA methylation is a fundamental epigenetic mechanism for silencing gene expression by either modifying chromatin structure to a repressive state or interfering with the transcription factors’ binding. DNA methylation primarily occurs at the...
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Antibody 5mC (C15200081)
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
Published: February, 2016
Abstract: Intragenic 5-methylcytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing, whereas 5-methylcytosine evicts CTCF, leading to exon exclusion. However, the mec...
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Antibody
Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes
Published: January, 2016
Abstract: Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) is a method that allows the study of protein complexes, in particular chromatin and transcription factor complexes, in a rapid and robust manner by mass spectrometry (MS). Th...
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Bioruptor Bioruptor Plus
Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
Published: January, 2016
Abstract: Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, ...
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Antibody
RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine.
Published: January, 2016
Abstract: Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, ...
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Antibody
Chromatin Immunoprecipitation Assay for the Identification of Arabidopsis Protein-DNA Interactions In Vivo
Published: January, 2016
Abstract: Intricate gene regulatory networks orchestrate biological processes and developmental transitions in plants. Selective transcriptional activation and silencing of genes mediate the response of plants to environmental signals and developmental cues...
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Bioruptor Antibody
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
Published: January, 2016
Abstract: Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC; refs ,,,). Here we demonstrate ...
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Antibody 5mC (C15200081)
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
Published: January, 2016
Abstract: The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone de...
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Antibody
DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro
Published: January, 2016
Abstract: Growing evidence suggests that the lysine methyltransferase DOT1L/KMT4 has important roles in proliferation, survival, and differentiation of stem cells in development and in disease. We investigated the function of DOT1L in neural stem cells (NSC...
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Antibody
Functional characterization of the hGRαT556I causing Chrousos syndrome
Published: January, 2016
Abstract: BACKGROUND: Chrousos syndrome is a rare pathologic condition characterized by generalized, partial resistance of target tissues to glucocorticoids and caused by inactivating mutations of the human glucocorticoid receptor (hGR) gene. A novel case ...
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Antibody
MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
Published: December, 2015
Abstract: Targeted therapies designed to exploit specific molecular pathways in aggressive cancers are an exciting area of current research. Mixed Lineage Leukemia (MLL) mutations such as the t(4;11) translocation cause aggressive leukemias that are refract...
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Antibody
cChIP-seq: a robust small-scale method for investigation of histone modifications
Published: December, 2015
Abstract: Background ChIP-seq is highly utilized for mapping histone modifications that are informative about gene regulation and genome annotations. For example, applying ChIP-seq to histone modifications such as H3K4me1 has facilitated generating epige...
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Antibody
Embryonic transcription is controlled by maternally defined chromatin state
Published: December, 2015
Abstract: Histone-modifying enzymes are required for cell identity and lineage commitment, however little is known about the regulatory origins of the epigenome during embryonic development. Here we generate a comprehensive set of epigenome reference maps, ...
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Antibody
Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.
Published: December, 2015
Abstract: Formative research suggests that a human embryonic stem cell-specific alternative splicing gene regulatory network, which is repressed by Muscleblind-like (MBNL) RNA binding proteins, is involved in cell reprogramming. In this study, RNA sequencin...
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Antibody
Germline organization in Strongyloides nematodes reveals alternative differentiation and regulation mechanisms.
Published: December, 2015
Abstract: Nematodes of the genus Strongyloides are important parasites of vertebrates including man. Currently, little is known about their germline organization or reproductive biology and how this influences their parasitic life strategies. Here, we analy...
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Antibody
Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome
Published: December, 2015
Abstract: The chromosomal protein SMCHD1 plays an important role in epigenetic silencing at diverse loci, including the inactive X chromosome, imprinted genes, and the facioscapulohumeral muscular dystrophy locus. Although homology with canonical SMC family...
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Antibody
DNA methylation profiling: comparison of genome-wide sequencing methods and the Infinium Human Methylation 450 Bead Chip
Published: December, 2015
Abstract: AIMS: To compare the performance of four sequence-based and one microarray methods for DNA methylation profiling. METHODS: DNA from two cell lines were profiled by reduced representation bisulfite sequencing, methyl capture sequencing (SS-Met...
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MagMeDIP kit Antibody 5mC (C15200081)
A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice
Published: December, 2015
Abstract: Autoimmune regulator (Aire) has a unique expression pattern in thymic medullary epithelial cells (mTECs), in which it plays a critical role in the activation of tissue-specific antigens. The expression of Aire in mTECs is activated by receptor act...
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Antibody IP-Star Compact
Oxidative DNA damage in mouse sperm chromosomes: Size matters.
Published: December, 2015
Abstract: Normal embryo and foetal development as well as the health of the progeny are mostly dependent on gamete nuclear integrity. In the present study, in order to characterize more precisely oxidative DNA damage in mouse sperm we used two mouse models ...
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Antibody
Transient generalized glucocorticoid hypersensitivity
Published: December, 2015
Abstract: BACKGROUND: Transient generalized glucocorticoid hypersensitivity is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypo-activation of the hypothalamic-pituitary-adrenal axis. The condition itsel...
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Antibody
The Cytoplasmic Region of Plasmodium falciparum SURFIN4.2 Is Required for Transport from Maurer’s Clefts to the Red Blood Cell Surface
Published: December, 2015
Abstract: Background: Plasmodium, the causative agent of malaria, exports many proteins to the surface of the infected red blood cell (iRBC) in order to modify it toward a structure more suitable for parasite development and survival. One such exported pr...
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Antibody
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes
Published: December, 2015
Abstract: Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly understood, but a nu...
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Antibody True MicroChIP kit

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