什么是 ChIP，为什么有用？

ChIP immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a specific protein of interest, giving invaluable insights into the regulation of gene expression. ChIP is frequently used in studies that focus on cellular differentiation, tumor suppressor gene silencing, the effect of histone modifications on gene expression, and other studies involving transcriptional activation and repression.

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Articles

• Why antibodies for ChIP matter
• Why chromatin shearing matters