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ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング

Watch the webinar to gain insights on how data mining can be applied for epigenetics applications

Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。

患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。

Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。

異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。

Epigenetic data

Transcriptomic data

DNA Methylation (RRBS, WGBS, EPIC arrays)

ChIP-sequencing

ATAC-seq

mRNA-sequencing

Small and long non coding RNA

Single-cell RNA-sequencing

Biological Interpretation

機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。

WHITE PAPERS

Smokers vs non-smokers

Breast cancer

Powerful new insights with epigenetic data mining.
A study to distinguish smokers from non-smokers using just one droplet of blood

Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.
(...)
Read more

Data mining on DNA methylation data in cancer samples
Distinguishing normal from breast cancer tissue

Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.

One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.
(...)
Read more

Insights
1. Feasibility study
- Assessment of data characteristics and applicability of different machine learning (ML)
- Prototypic analyses:
- Initial feasibility report
1. Data Mining
- Machine learning on data
- Data evaluation and validation
- Report generation
1. Data Interpretation
- Integration of background knowledge
- Functional interpretation / pathway mining
- Scientific reporting
Case study
A clear advantage of Diagenode’s data mining services is the close connection with other service offerings like wet lab analysis services and bioinformatics services. You can retrieve a full service package from a single source.

Read about our wetlab services
資料
Epigenomics Profiling Services FLYER
Chromatin analysis DNA methylation services RNA-seq analysis Download

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<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
<p></p>
<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
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<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
</td>
</tr>
</tbody>
</table>
<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
<div id="portal" class="main-portal">
<div class="portal-inner"><nav class="portal-nav" style="text-align: left;">
<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
</ul>
</nav></div>
</div>
<div class="tabs-content">
<div class="content active" id="panel1">
<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
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<li>Prototypic analyses:</li>
<li>Initial feasibility report</li>
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<p></p>
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<p><a href="https://www.diagenode.com/en/categories/Services">Read about our wetlab services</a></p>
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		'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
<p></p>
<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/KXjnSHz3Jk8" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen="allowfullscreen"></iframe></center>
<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
</td>
</tr>
</tbody>
</table>
<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
<div id="portal" class="main-portal">
<div class="portal-inner"><nav class="portal-nav" style="text-align: left;">
<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
</ul>
</nav></div>
</div>
<div class="tabs-content">
<div class="content active" id="panel1">
<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
</div>
</blockquote>
</div>
</div>',
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</ol>
<ul>
<li>Assessment of data characteristics and <span></span>applicability of different machine learning (ML)</li>
<li>Prototypic analyses:</li>
<li>Initial feasibility report</li>
</ul>
<p></p>
<ol start="2">
<li><strong>Data Mining</strong></li>
</ol>
<ul>
<li>Machine learning on data</li>
<li>Data evaluation and validation</li>
<li>Report generation</li>
</ul>
<p>&nbsp;</p>
<ol start="3">
<li><strong>Data Interpretation</strong></li>
</ol>
<ul>
<li>Integration of background knowledge</li>
<li>Functional interpretation / pathway mining</li>
<li>Scientific reporting</li>
</ul>
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<p><a href="https://www.diagenode.com/en/categories/Services">Read about our wetlab services</a></p>
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<h2 class="diacol">ADVANTAGES</h2>
<ol>
<li>The bioinformatics team works constantly to optimize pipelines to deliver biologically meaningful results within a short turnaround time</li>
<li>Flexible and communicative team work in close collaboration with you to adapt to your analysis requirements</li>
<li>We help you shape the methods section of your manuscripts</li>
<li>We back up our internal servers daily to protect your data</li>
<li>We have great computing capacity to undertake large projects.</li>
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<div class="extra-spaced">
<h2>Check out our service offerings</h2>
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<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/chromatin-data-analysis">Chromatin studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/methylation-data-analysis">Methylation studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/rna-data-analysis">RNA studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/integrative-analysis">Integrative analysis of multiple omics data</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/data-mining-service">Data mining with machine learning techniques</a></li>
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<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
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<li>ChIP-seq analysis Histone modification</li>
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<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
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<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
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<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
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<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
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<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
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<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
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<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
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<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
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<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
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<li>
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<h2>12 years of expertise and trust in epigenetics</h2>
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<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
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<div class="small-12 medium-8 large-8 columns"><center><img src="http://www.diagenode.com/img/applications/histone-marks-helice.png" alt="Histone-Antibodies-Diagenode" /></center><br href="../p/service-chip-seq" />
<h3><a href="../p/atac-seq-service">ATAC-seq: open chromatin regions</a></h3>
<p>Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.</p>
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<p>Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation</p>
<ul>
<li><strong>Active promoter profiling</strong>: H3K4me3 enrichment</li>
<li><strong>Inactive promoter profiling</strong>: H3K27me3 enrichment</li>
<li><strong>Enhancer profiling</strong>: H3K4me1 and H3K27ac enrichment in regulatory regions</li>
<li><strong>Active gene body</strong>: H3K36me3</li>
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<p>Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:</p>
<ul>
<li>CTCF: transcriptional repressor and insulator activity</li>
<li>p300/CBP: histone acetyltransferase</li>
<li>Pol II, p53, and more</li>
<li>Epigenetic writers, readers, erasers</li>
<li>Nuclear receptors</li>
<li>Tumor suppressor genes</li>
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<div class="panel"><center><img alt="RNA-seq-Diagenode" src="http://www.diagenode.com/img/categories/services/rna-workflow.png" /></center>
<p><br />RNA-seq is a revolutionary technique that examines the total cellular content of RNAs, the transcriptome, using deep-sequencing technologies. Obtaining data about the transcriptome allows to connect the information on a genome with its functional protein expression. It provides great insights into cell development mechanisms and disease-associated modifications.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns"><a href="https://www.diagenode.com/en/p/high-throughput-3mrna-seq-services"></a>
<h3><a href="https://www.diagenode.com/en/p/mrna-seq-services">mRNA analysis</a></h3>
<ul class="text-left">
<li>Recognition of protein-coding RNAs with specific poly A selection</li>
<li>Superior complexity and high transcript coverage</li>
<li>Accurate comparison of gene expression levels</li>
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<!--<h3 class="text-left"><a href="https://www.diagenode.com/en/p/small-rna-seq-services">Small non-coding RNA including miRNA analysis</a></h3>
<ul class="text-left">
<li>Realistic representation of all small non-coding RNAs</li>
<li>Detection of novel transcripts and differentially-expressed small RNAs</li>
<li>Investigation of post-transcriptional regulation of gene expression</li>
<li>Leveraging the <a href="https://www.diagenode.com/en/pages/dplex">D-Plex technology</a></li>
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<h3 class="text-left"><a href="https://www.diagenode.com/en/p/rna-seq-services">Whole transcriptome including long non-coding RNA analysis</a></h3>
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<li>Investigation of the structure of genes, their splicing patterns and other post transcriptional modifications</li>
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Our Epigenomics Profiling Services helps you to complete your transcriptomic profiling analysis using next-generation sequencing (NGS). Our experienced scientists will help you design your RNA-seq experiments based on the ultimate goal of your transcriptomic profiling analysis by generating meaningful RNA-seq libraries and delivering high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</div>
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<div class="panel"><center><img src="http://www.diagenode.com/img/categories/services/dna-workflow.png" alt="DNA-methylation -Diagenode" /></center>
<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns">
<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
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<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 285,000&nbsp;markers detected in&nbsp;mouse samples at single nucleotide resolution</li>
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<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
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<li>Robust and cost-effective solution with&nbsp;reliable results</li>
<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
<ul>
<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
<ul>
<li>Focus on D<span>NA methylation patterning of selective regions with single nucleotide resolution</span></li>
<li><span>Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture</span></li>
<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
<li><span>Allowing deep sequencing at high coverage levels for rare variant identification</span></li>
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<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
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<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
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<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
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			'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
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<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/KXjnSHz3Jk8" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen="allowfullscreen"></iframe></center>
<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
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</tbody>
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<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
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<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
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</nav></div>
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<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
</div>
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<p><a href="https://www.diagenode.com/en/categories/Services">Read about our wetlab services</a></p>
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		'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
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<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
</td>
</tr>
</tbody>
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<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
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<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
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<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
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<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
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<h2 class="diacol">ADVANTAGES</h2>
<ol>
<li>The bioinformatics team works constantly to optimize pipelines to deliver biologically meaningful results within a short turnaround time</li>
<li>Flexible and communicative team work in close collaboration with you to adapt to your analysis requirements</li>
<li>We help you shape the methods section of your manuscripts</li>
<li>We back up our internal servers daily to protect your data</li>
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<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/chromatin-data-analysis">Chromatin studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/methylation-data-analysis">Methylation studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/rna-data-analysis">RNA studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/integrative-analysis">Integrative analysis of multiple omics data</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/data-mining-service">Data mining with machine learning techniques</a></li>
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<div class="small-12 medium-10 large-10 columns text-left">
<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<div class="small-12 medium-2 large-2 columns text-left"><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></div>
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<div class="panel" style="border-color: #099f92;">
<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
<li>ChIP-seq analysis Histone modification</li>
<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
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</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
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<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
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<ul class="small-block-grid-2 medium-block-grid-3 large-block-grid-3">
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
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<h2>12 years of expertise and trust in epigenetics</h2>
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<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
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<p>Chromatin consists of DNA, histones and non-histone proteins. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.</p>
<p>Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to&nbsp;elucidate&nbsp;control of gene expression in disease or in response to a drug treatment. Diagenode&rsquo;s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns"><center><img src="http://www.diagenode.com/img/applications/histone-marks-helice.png" alt="Histone-Antibodies-Diagenode" /></center><br href="../p/service-chip-seq" />
<h3><a href="../p/atac-seq-service">ATAC-seq: open chromatin regions</a></h3>
<p>Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.</p>
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<p>Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation</p>
<ul>
<li><strong>Active promoter profiling</strong>: H3K4me3 enrichment</li>
<li><strong>Inactive promoter profiling</strong>: H3K27me3 enrichment</li>
<li><strong>Enhancer profiling</strong>: H3K4me1 and H3K27ac enrichment in regulatory regions</li>
<li><strong>Active gene body</strong>: H3K36me3</li>
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<h3><a href="../p/service-chip-seq">ChIP-seq Transcription Factors</a></h3>
<p>Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:</p>
<ul>
<li>CTCF: transcriptional repressor and insulator activity</li>
<li>p300/CBP: histone acetyltransferase</li>
<li>Pol II, p53, and more</li>
<li>Epigenetic writers, readers, erasers</li>
<li>Nuclear receptors</li>
<li>Tumor suppressor genes</li>
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<div class="panel"><center><img alt="RNA-seq-Diagenode" src="http://www.diagenode.com/img/categories/services/rna-workflow.png" /></center>
<p><br />RNA-seq is a revolutionary technique that examines the total cellular content of RNAs, the transcriptome, using deep-sequencing technologies. Obtaining data about the transcriptome allows to connect the information on a genome with its functional protein expression. It provides great insights into cell development mechanisms and disease-associated modifications.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns"><a href="https://www.diagenode.com/en/p/high-throughput-3mrna-seq-services"></a>
<h3><a href="https://www.diagenode.com/en/p/mrna-seq-services">mRNA analysis</a></h3>
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<!--<h3 class="text-left"><a href="https://www.diagenode.com/en/p/small-rna-seq-services">Small non-coding RNA including miRNA analysis</a></h3>
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<p>The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation &ndash; hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.</p>
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<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
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<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
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<li>Unique technology enables low DNA inputs down to 25ng</li>
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<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
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<li>Very powerful solution for genome-wide biomarker discovery&nbsp;using bisulfite or enzymatic conversion</li>
<li><span>Evaluation of methylation status of nearly every CpG sites of the entire genome&nbsp;</span>at single&nbsp;nucleotide resolution</li>
<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
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<li>Focus on D<span>NA methylation patterning of selective regions with single nucleotide resolution</span></li>
<li><span>Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture</span></li>
<li><span>Enhanced accuracy, sensitivity and specificity while reducing overall cost</span></li>
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<li>Immunoprecipitation assay (antibody-based approach) to study 5-mC genome-wide</li>
<li>Resolution of 100-500 bp</li>
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<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
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			'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
<p></p>
<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/KXjnSHz3Jk8" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen="allowfullscreen"></iframe></center>
<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
</td>
</tr>
</tbody>
</table>
<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
<div id="portal" class="main-portal">
<div class="portal-inner"><nav class="portal-nav" style="text-align: left;">
<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
</ul>
</nav></div>
</div>
<div class="tabs-content">
<div class="content active" id="panel1">
<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
</div>
</blockquote>
</div>
</div>',
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<p></p>
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<p><a href="https://www.diagenode.com/en/categories/Services">Read about our wetlab services</a></p>
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		'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
<p></p>
<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/KXjnSHz3Jk8" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen="allowfullscreen"></iframe></center>
<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
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<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
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<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
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<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
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<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
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<div class="portal-inner"><nav class="portal-nav" style="text-align: left;">
<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
</ul>
</nav></div>
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<div class="content active" id="panel1">
<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
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<div class="small-12 medium-12 large-12 columns">
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<div class="extra-spaced">
<h2 class="diacol">ADVANTAGES</h2>
<ol>
<li>The bioinformatics team works constantly to optimize pipelines to deliver biologically meaningful results within a short turnaround time</li>
<li>Flexible and communicative team work in close collaboration with you to adapt to your analysis requirements</li>
<li>We help you shape the methods section of your manuscripts</li>
<li>We back up our internal servers daily to protect your data</li>
<li>We have great computing capacity to undertake large projects.</li>
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<div class="extra-spaced">
<h2>Check out our service offerings</h2>
<ul class="nobullet">
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/chromatin-data-analysis">Chromatin studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/methylation-data-analysis">Methylation studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/rna-data-analysis">RNA studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/integrative-analysis">Integrative analysis of multiple omics data</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/data-mining-service">Data mining with machine learning techniques</a></li>
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<div class="small-12 medium-10 large-10 columns text-left">
<p>Our Epigenomics Profiling Services assure the sample preparation expertise and quality data that you seek. We provide epigenome-wide analyses for understanding epigenetic mechanisms, epigenetics-related drug discovery, transgenerational epigenetics studies, epigenetic biomarker identification (including epigenomic cancer biomarkers), and functional epigenomics. Diagenode offers expert epigenomics services that you can trust for chromatin, DNA, and RNA analysis.&nbsp;</p>
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<div class="small-12 medium-2 large-2 columns text-left"><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></div>
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<center><img alt="DNA-RNA-Chromatin-Diagenode" src="https://www.diagenode.com/img/categories/services/chromatin-dna-rna.png" /></center>
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<div class="panel" style="border-color: #099f92;">
<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
<li>ChIP-seq analysis Histone modification</li>
<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
<ul>
<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
</ul>
<div class="extra-spaced">
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
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<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
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<li>Presentation-<strong>quality data</strong> and graphs</li>
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<p>Chromatin consists of DNA, histones and non-histone proteins. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.</p>
<p>Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to&nbsp;elucidate&nbsp;control of gene expression in disease or in response to a drug treatment. Diagenode&rsquo;s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.</p>
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<h3><a href="../p/atac-seq-service">ATAC-seq: open chromatin regions</a></h3>
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<ul>
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<h3><a href="../p/service-chip-seq">ChIP-seq histone modifications</a></h3>
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<h3><a href="../p/service-chip-seq">ChIP-seq Transcription Factors</a></h3>
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<h3><a href="https://www.diagenode.com/en/p/mrna-seq-services">mRNA analysis</a></h3>
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<p>Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will&nbsp;process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</p>
<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
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<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
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<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
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<li>Unique technology enables low DNA inputs down to 25ng</li>
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<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
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<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
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<!--<h3><a href="../p/medip-seq-service">Methylated DNA IP Sequencing</a></h3>
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<li>Resolution of 100-500 bp</li>
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<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
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			'name' => 'データマイニングサービス',
			'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
<p></p>
<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
</div>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/KXjnSHz3Jk8" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen="allowfullscreen"></iframe></center>
<p></p>
<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
<table class="extra-spaced">
<tbody>
<tr>
<td><strong>Epigenetic data</strong></td>
<td><strong>Transcriptomic data</strong></td>
</tr>
<tr>
<td>
<p>DNA Methylation (RRBS, WGBS, EPIC arrays)</p>
<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
</td>
<td>
<p>mRNA-sequencing</p>
<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
</td>
</tr>
</tbody>
</table>
<p></p>
<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
<div class="row">
<div class="small-12 medium-12 large-12 columns">
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<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
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<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
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		'description' => '<h2 class="text-center"><span class="diacol">New!</span></h2>
<h2 style="text-align: center;">ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング</h2>
<h2 class="text-center"><img src="https://www.diagenode.com/img/product/data-mining-long.png" style="color: #222222; font-family: 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-size: 16px;" /></h2>
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<div id="paper" style="text-align: center;">
<h4><a href="https://www.youtube.com/watch?v=KXjnSHz3Jk8">Watch the webinar to gain insights on how data mining can be applied for epigenetics applications</a></h4>
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<p>Diagenodeの新しいデータマイニングサービスは、先端技術のAI（機械学習）、統計、およびデータベースシステムの方法を利用しています。 この拡張サービスは、大規模なデータセットのパターンを分析して有益な新しい洞察を提供することにより、これまでにない新たな発見をサポートします。</p>
<p>患者コホート、単一細胞解析、または他の異種シナリオからのデータがある場合も、最新のデータマイニング機能を使用した最適なデータ分析により徹底したサポートを提供します。AI（機械学習技術）を採用することで、データセット内およびデータセット間で未発見または不明確な関係を見つけ出す可能性が大幅に広がります。この高度なテクノロジーにより、無駄骨を折ることなく大量のデータから有益な機能を発見できます。</p>
<p>Diagenodeのこのサービスは複数のアルゴリズムを使用して高度なデータマイニングを実現し、データ固有の最適なアルゴリズムの組み合わせを利用します。関連データに応じてデータを2つ以上のクラスまたはグループに分離する強力な分類子の構築を目標としています。</p>
<p>異なる複数の-omicsデータクラスを同時にマイニングや、表現型および/または臨床データとの統合も可能です。以下を含む複数のデータクラスのデータマイニングサービスを提供しています。</p>
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<p>ChIP-sequencing</p>
<p>ATAC-seq</p>
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<p>Small and long non coding RNA</p>
<p>Single-cell RNA-sequencing</p>
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<p><strong>Biological Interpretation</strong></p>
<p>機械学習分類子は、クラス間の基本的な生物学的差異を反映するだけでなく、作業中の分子プロセスを明らかにするために使用されます。これに伴いデータの生物学的解釈サービスと経路マイニング解析を提供しています。</p>
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<div class="small-12 medium-12 large-12 columns">
<blockquote style="padding-bottom: 0;"><span class="label-green" style="margin-bottom: 16px; margin-left: -22px;">WHITE PAPERS</span>
<div id="portal" class="main-portal">
<div class="portal-inner"><nav class="portal-nav" style="text-align: left;">
<ul data-tab="" class="tips-menu">
<li><a href="#panel1" class="tips portal button">Smokers vs non-smokers </a></li>
<li><a href="#panel2" class="tips portal button">Breast cancer</a></li>
</ul>
</nav></div>
</div>
<div class="tabs-content">
<div class="content active" id="panel1">
<h3 style="margin-top: 0;">Powerful new insights with epigenetic data mining.<br /> A study to distinguish smokers from non-smokers using just one droplet of blood</h3>
<p>Next generation sequencing in combination with sophisticated bioinformatics technologies for genomic, transcriptomic and epigeneomic analyses have enormous potential to establish new biomarkers for disease diagnostics, enabling true precision medicine. Analyses of liquid biopsies to measure thousands of different data points simultaneously in easily accessible body fluids (e.g. blood, urine, and saliva) are extremely promising for such biomarker studies.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo" class="alert small button">Read more</a></div>
<div class="content" id="panel2">
<h3 style="margin-top: 0;">Data mining on DNA methylation data in cancer samples<br />Distinguishing normal from breast cancer tissue</h3>
<p>Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall.</p>
<p>One important aspect of cancer tissues it that they differ from normal tissues in their epigenetic make up, especially in the DNA methylation pattern. In normal cells methylation assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications, and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture.<br />(...)</p>
<a href="https://www.diagenode.com/jp/pages/form-bioinfo?app_note=23" class="alert small button">Read more</a></div>
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<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/methylation-data-analysis">Methylation studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/rna-data-analysis">RNA studies</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/integrative-analysis">Integrative analysis of multiple omics data</a></li>
<li><i class="fa fa-arrow-circle-right"></i> <a href="https://www.diagenode.com/en/p/data-mining-service">Data mining with machine learning techniques</a></li>
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<h3><span class="green">Chromatin</span>&nbsp;analysis</h3>
<ul>
<li>ChIP-seq analysis Histone modification</li>
<li>Promoter analysis</li>
<li>Enhancer analysis</li>
<li>ChIP-seq analysis Transcription factor&nbsp;</li>
<li>(sc)ATAC-seq Chromatin accessibility</li>
<li>ChIP-seq Cas9 off-target</li>
<li>Customized NGS service</li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/chip-seq-service">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #474546;">
<h3><span class="darkgrey">DNA methylation</span> analysis</h3>
<ul>
<li>Reduced representation bisulfite sequencing (RRBS)</li>
<li>Whole genome bisulfite sequencing (WGBS)</li>
<li>Targeted methylation</li>
<li>MeDIP-seq/hMeDIP-seq</li>
<li>Infinium MethylationEPIC array&nbsp;</li>
</ul>
<p></p>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/dna-methylation-profiling-services">Learn more</a></p>
</div>
</div>
<div class="small-12 medium-4 large-4 columns text-left">
<div class="panel" style="border-color: #b11e33;">
<h3><span class="diacol"><g class="gr_ gr_44 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="44" data-gr-id="44">RNA-seq</g></span> analysis</h3>
<ul>
<li><span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Gene expression profiling</span></li>
<li>mRNA<span style="display: inline !important; float: none; background-color: #f8f8f8; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> analysis</span></li>
<li>Small non-coding RNA analysis</li>
<li><b></b>Whole transcriptome analysis<br /><br /><br /><br /><br /></li>
</ul>
<p><i class="fa fa-arrow-circle-right"></i> <a href="../categories/rna-seq-category">Learn more</a></p>
</div>
</div>
</div>
<h2 style="text-align: center;"><a class="details radius small button" href="https://www.diagenode.com/en/documents/services-flyer">DOWNLOAD OUR FLYER</a></h2>
<h2>Why Diagenode</h2>
<ul>
<li><strong>Expertise and trust</strong>: Recognized epigenetics leader, official partner of <a href="http://www.blueprint-epigenome.eu/"><g class="gr_ gr_45 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling ins-del multiReplace" id="45" data-gr-id="45">BLUEPRINT</g></a>, <a href="http://ihec-epigenomes.org/">IHEC</a> <g class="gr_ gr_46 gr-alert gr_gramm gr_inline_cards gr_disable_anim_appear Punctuation only-ins replaceWithoutSep" id="46" data-gr-id="46">and</g> <a href="https://www.faang.org/">FAANG</a></li>
<li><strong>Innovative technology</strong>: Utilization of the signature Bioruptor<sup>&reg;</sup> sonication device for optimal chromatin and DNA shearing and the IP-Star<sup>&reg;</sup> Automation device give reproducible and reliable optimization and results</li>
<li><strong>Quality</strong>: Multiple QC steps in all workflows and validated antibodies plus reagents deliver superior data</li>
<li><strong>Flexibility</strong>: Extensive range of sample species and sample origins</li>
<li><strong>Experience</strong> in epigenomics profiling for a wide range of applications and fields of interest</li>
</ul>
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">HUMAN</span><center><img width="260" height="259" alt="services chip-seq - human" src="https://www.diagenode.com/img/categories/services/services-humans.png" caption="false" /></center></div>
</li>
<li>
<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">ANIMALS</span><center><img width="260" height="259" alt="services chip-seq - animals" src="https://www.diagenode.com/img/categories/services/services-animals.png" caption="false" /></center></div>
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<div class="block-distri"><span class="label-green" style="margin-bottom: 16px; margin-left: -3px;">PLANTS</span><center><img width="260" height="259" alt="services methylation-plant" src="https://www.diagenode.com/img/categories/services/services-plants.png" caption="false" /></center></div>
</li>
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<h2>12 years of expertise and trust in epigenetics</h2>
<ul>
<li><strong>End-to-end</strong> epigenetic service</li>
<li><strong>Collaborative</strong> and customized project design</li>
<li>Dedicated <strong>in-house expert</strong> for your project</li>
<li><strong>Integrative</strong> data analysis</li>
<li>Presentation-<strong>quality data</strong> and graphs</li>
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<p>Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to&nbsp;elucidate&nbsp;control of gene expression in disease or in response to a drug treatment. Diagenode&rsquo;s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.</p>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns"><center><img src="http://www.diagenode.com/img/applications/histone-marks-helice.png" alt="Histone-Antibodies-Diagenode" /></center><br href="../p/service-chip-seq" />
<h3><a href="../p/atac-seq-service">ATAC-seq: open chromatin regions</a></h3>
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<h3><a href="../p/service-chip-seq">ChIP-seq histone modifications</a></h3>
<p>Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation</p>
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<li><strong>Inactive promoter profiling</strong>: H3K27me3 enrichment</li>
<li><strong>Enhancer profiling</strong>: H3K4me1 and H3K27ac enrichment in regulatory regions</li>
<li><strong>Active gene body</strong>: H3K36me3</li>
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<h3><a href="../p/service-chip-seq">ChIP-seq Transcription Factors</a></h3>
<p>Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:</p>
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<li>p300/CBP: histone acetyltransferase</li>
<li>Pol II, p53, and more</li>
<li>Epigenetic writers, readers, erasers</li>
<li>Nuclear receptors</li>
<li>Tumor suppressor genes</li>
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<center><img src="https://www.diagenode.com/img/logo-scientist-registered-supplier.png" /></center></div>
<div class="small-12 medium-8 large-8 columns"><a href="https://www.diagenode.com/en/p/high-throughput-3mrna-seq-services"></a>
<h3><a href="https://www.diagenode.com/en/p/mrna-seq-services">mRNA analysis</a></h3>
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<!--<h3 class="text-left"><a href="https://www.diagenode.com/en/p/small-rna-seq-services">Small non-coding RNA including miRNA analysis</a></h3>
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<li>Investigation of post-transcriptional regulation of gene expression</li>
<li>Leveraging the <a href="https://www.diagenode.com/en/pages/dplex">D-Plex technology</a></li>
</ul>-->
<h3 class="text-left"><a href="https://www.diagenode.com/en/p/rna-seq-services">Whole transcriptome including long non-coding RNA analysis</a></h3>
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<li>Investigation of the structure of genes, their splicing patterns and other post transcriptional modifications</li>
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Our Epigenomics Profiling Services helps you to complete your transcriptomic profiling analysis using next-generation sequencing (NGS). Our experienced scientists will help you design your RNA-seq experiments based on the ultimate goal of your transcriptomic profiling analysis by generating meaningful RNA-seq libraries and delivering high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.</div>
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<h3><a href="https://www.diagenode.com/en/p/infinium-methylation-epic-array-v2-service">Infinium MethylationEPIC Array Service V2</a></h3>
<ul>
<li>Cost-effective solution with rapid turnaround time</li>
<li>Over 930,000 CpGs detected in human samples at single nucleotide resolution</li>
<li>Quantitative interrogation of CpG, non-CpG, and CHH sites</li>
<li>Differential methylation analysis&nbsp;<span>using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
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<!--<h3><a href="https://www.diagenode.com/en/p/infinium-mouse-methylation-array-service">Infinium Mouse Methylation Array Service</a></h3>
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<li>Over 285,000&nbsp;markers detected in&nbsp;mouse samples at single nucleotide resolution</li>
<li>Suitable for common laboratory mouse strains</li>
<li><span>Differential methylation analysis&nbsp;using our<span>&nbsp;</span><a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
</ul>-->
<h3><a href="https://www.diagenode.com/en/p/rrbs-service">Reduced Representation Bisulfite Sequencing (RRBS) Service</a></h3>
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<li>Unique technology enables low DNA inputs down to 25ng</li>
<li>Accurate analyses with UDIs and UMIs</li>
<li>Up to 7&nbsp;million CpGs detected in human samples at single nucleotide resolution</li>
<li>Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands</li>
<li><span>Differential methylation analysis&nbsp;<span>using our</span> <a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></span></li>
<li>Suitable for epigenetic biomarker discovery</li>
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<h3><a href="https://www.diagenode.com/en/p/wgbs-service">Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service</a></h3>
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<li>Detection of global methylation patterns&nbsp;including in low CpG-density regions and outside of CpG islands</li>
<li>Identification of regions or even loci with differential methylation&nbsp;levels between groups using our&nbsp;<a href="https://www.diagenode.com/en/categories/bioinformatics-service">bioinformatics tools</a></li>
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<h3><a href="https://www.diagenode.com/en/p/targeted-dna-methylation-service">Targeted&nbsp;Bisulfite Sequencing Service</a></h3>
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<ul>
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<li>Resolution of 100-500 bp</li>
</ul>-->
<h3><a href="../p/human-methylome-service">Human Methylome</a></h3>
<h3>Watch our webinar:</h3>
<p>Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel</p>
<a class="popup-youtube" href="#webinar"><img src="https://www.diagenode.com/img/webinar/eshg-miniature.png" class="webinar" alt="Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel" /></a>
<p></p>
<ul>
<li>NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy</li>
<li>Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases</li>
<li>High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)</li>
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Milwaukee, Wisconsin, USA
May 6-May 9, 2024
London Calling 2024
London, UK
May 21-May 24, 2024
Symposium of the Young Scientist Association
Vienna, Austria
May 28-May 29, 2024

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The European Regional Development Fund and Wallonia are investing in your future.

Extension of industrial buildings and new laboratories.

データマイニングサービス

New!

ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング

Watch the webinar to gain insights on how data mining can be applied for epigenetics applications

Powerful new insights with epigenetic data mining.
A study to distinguish smokers from non-smokers using just one droplet of blood

Data mining on DNA methylation data in cancer samples
Distinguishing normal from breast cancer tissue

How to properly cite this product in your work

イベント

ニュース

データマイニングサービス

New!

ユニークなエピジェネティックなデータ洞察に（AI）を使用したデータマイニング

Powerful new insights with epigenetic data mining. A study to distinguish smokers from non-smokers using just one droplet of blood

Data mining on DNA methylation data in cancer samplesDistinguishing normal from breast cancer tissue

How to properly cite this product in your work

イベント

ニュース

Powerful new insights with epigenetic data mining.
A study to distinguish smokers from non-smokers using just one droplet of blood

Data mining on DNA methylation data in cancer samples
Distinguishing normal from breast cancer tissue