Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity

Chang Richard C., Thomas Kara N., Bedi Yudhishtar S., Golding. Michael C.

Paternally inherited alterations in epigenetic programming are emerging as relevant factors in numerous disease states, including the growth and metabolic defects observed in fetal alcohol spectrum disorders. In rodents, chronic paternal alcohol use induces fetal growth restriction, as well as sex-specific alterations in insulin signaling and lipid homeostasis in the offspring. Based on previous studies, we hypothesized that the observed metabolic irregularities are the consequence of paternally inherited alterations liver x receptor (LXR) activity.

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September, 2019


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  • IMB Conference on "Epigenetics of Ageing - Responses to Adversity across Scales" 2022
    Rheinland-Pfalz, Germany
    Jun 28-Jul 1, 2022
  • CNET 2022
    Gif-Sur-Yvette, France
    Jul 4-Jul 6, 2022



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